• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

The C in CWE is unnecessary

W

wreckhead

Bluelighter
Joined
Dec 22, 2008
Messages
58
According to the source below (and others), acetaminophen dissolves at about 15mg/ml in 25C water. This means if you put some codeine tablets in 50ml of water, you would only get 750mg of APAP. The amount of water could be reduced further, but 50ml is a reasonable amount to extract as much codeine as you need.

I've done this before with enough APAP to kill me, yet I am not dead. It definitely works.

http://pharmtech.findpharma.com/pha...rystal-/ArticleStandard/Article/detail/378746

Therefore, the C in CWE is unnecessary.
 
Pretty much, but it doesn't hurt to keep it chilled and minimize the APAP intake. I usually just use cool tap water, possibly after it being in the fridge a while if I can be bothered, and it works fine.

Wouldn't used boiling hot water, but some of the extremes people go to (leaving it in the fridge overnight, etc) are completely unnecessary.
 
25 degrees is basically room temp. in many cases. That is in no way "hot".

No one ever suggested icy-cold water. The idea is that it isn't heated.
 
Well, the whole idea is to minimize the amount of APAP in the solution so, yes, the C is necessary if you want less impurities in the product.
 
Bringing the temperature down just further lowers the insolubility of paracetamol. If you wanna do codeine regularly you cant have paracetamol building up inside you, so you want to remove as much as possible.
 
You don't need to stick it in the fridge or freezer for hours no, but using tap-cold water is a good idea. All the using warm water then cooling it is a complete waste of time.
As mentioned, the colder the water the less Paracetamol ends up in the solution. But there won't be a dangerous amount in the water if it's not close to freezing.
There's too much paranoia surrounding the whole procedure which is unnecessary.
 
Better by far that people err on the side of caution though, especially when you're dealing with quantities of APAP that could potentially have very serious consequances if not filtered properly.
 
some of the TEKs for some reason use warm water to extract and then cool it, this is dumb because a cold solution of APAP made by cooling a warm solution no matter what its final temperature will always contain more APAP than a solution made by extracting using a cold solution, the reason is that cooling a warm solution allows the APAP to exceed its normal solubility limits and sit in solution supersaturated
 
I think it comes from A normal extraction during synthesis, where the solution you are wanting to grab product from is normall hot, cause you just got done with reflux. You then chill fast, so that crystals precip fast. I think they think that you must warm and chill fast to get better results.
 
Crankinit said:
Pretty much, but it doesn't hurt to keep it chilled and minimize the APAP intake. I usually just use cool tap water, possibly after it being in the fridge a while if I can be bothered, and it works fine.

Wouldn't used boiling hot water, but some of the extremes people go to (leaving it in the fridge overnight, etc) are completely unnecessary.
Click to expand...

I agree. In fact, and some might disagree, water that's too cold seems to prevent the desired result (IE the resulting solution is nice and clear of APAP, but not enough of the desired chemical is in the solution).
 
IMO colder is better. the tablets break up easier the colder it is, and since i use a poorer filter (like a cotton t shirt reason be because i want my codeine 5 mins after i walk out of the chemist not 40 mins) than a coffee filter, it makes all the difference. the colder the better the taste and clarity of the water. plus a few chunks of ice helps with the shaking of the pills to break them up.

in over 15 years ive never had a reaction to excess paracetamol though. and my lfts are fine
 
You must log in or register to reply here.
Top