IME Noopept has potentiated every mind or sensory expanding drug I've tried, psychedelics, rolling, and weed, etc. Oh except for dissociatives of course.
Nootropics The Big & Dandy Nootropics Thread (Stack 2)
- Thread starter infinity
- Start date
IME Noopept has potentiated every mind or sensory expanding drug I've tried, psychedelics, rolling, and weed, etc. Oh except for dissociatives of course.
Limpet_Chicken
Bluelighter
I've used both aniracetam and pramiracetam to rapidly abort dissociative effects.
I was on probation at one time for some explosives-related stuff, and having forgot I had to go see my probation officer, took quite a high dose of 4-MeO-PCP.
An IV dose of somewhere in the region of 5-600mg pramiracetam reversed the effects of the 4-MeO-PCP within minutes.
I was on probation at one time for some explosives-related stuff, and having forgot I had to go see my probation officer, took quite a high dose of 4-MeO-PCP.
An IV dose of somewhere in the region of 5-600mg pramiracetam reversed the effects of the 4-MeO-PCP within minutes.
Ekscentra
Bluelighter
- Joined
- Feb 20, 2014
- Messages
- 53
My experience with Coluracetam consists of typical racetam emotional blunting and an increase in depressive symptoms over a period of more than a few days. The most significant positive effect noticed has been an increase in writing abilities, both creative and otherwise. Word recall is significantly improved and, something I've noticed in most nootropics, a *slight* increase in muscle memory, though not anywhere near to the extent of IDRA-21. As with most nootropics for me, the positive benefits don't fully outweigh the negatives, and for this reason I'd avoid daily use. For occasional use, especially with regards to writing, I couldn't recommend this one more highly. The increase in depressive symptoms has been more marked than Piracetam, however, and for this reason I'd absolutely avoid any type of daily use until one can be sure his/her depressive symptoms have not increased. Any manifestation or increase in depressive symptoms and I'd suggest stopping the drug immediately. Due to lack of withdrawals, as noted by many others, I believe it's perfectly safe to suddenly stop use of the drug. The only withdrawals I've heard of have been psychological withdrawals from the only case of Piracetam addiction I've yet to see - the user in question was using multiple kilos of Piracetam per day, so it's doubtful anyone will experience any type of withdrawals at the typical doses used throughout these boards. This is not meaning to turn anyone off from the use of racetams, only to say that it's important we mention rare cases in order to better understand them when or if they come up again. Psychological addiction to piracetam *is* possible at ridiculously high doses and in individuals predisposed to such things, as could be said for nearly anything. Just something to keep in mind.
I've yet to try Coluracetam with any of the dissociatives. MXE is on the way, so I'll attempt this combination in 2 weeks and report back (without having tried MXE, I'll attempt to familiarize myself with the effects beforehand.) Piracetam didn't prevent my ability to hole on a 3rd plateau DXM trip, although Nicotine significantly potentiates dissociatives, in my experience. More likely the two cancelled each other out than anything.
Despite my general negativity towards IDRA in my last report, I have found it to be *very* useful in preventing the typical next-day stupidity from dissociatives and reversing all negative effects of Datura in regards to cognition. For this reason, it has become an invaluable part of my arsenal. Nothing so far has been able to achieve an immediate effect comparable to IDRA. I'd like to think Semax, Selank, NSI-189, and Cerebrolysin will be exceptions to this rule (and I'll soon be testing this theory.) For Alzheimer's and other cases of true cognitive deficiencies, I feel IDRA would be an excellent option. It's not to be used as a nootropic in the traditional sense, but used before, during, or after tripping, or in cases previously mentioned, IDRA has been extremely useful for me. In cases where it would otherwise be impossible to function the next day, IDRA reverses *all* noticeable effects on cognition and allows me to do what is needed. It's not an everyday option nor is it at all sustainable - I know I've said this before, but the point needs to be emphasized. In the end, I'm glad I've found a use for this incredible chemical rather than throwing out my batch over a few bad reactions. My opinion for IDRA hasn't changed, only expanded. Everything I've previously mentioned still holds true. I mentioned before that IDRA certainly had limited uses; until now, I was unable to determine what exactly those were - I'm now confident I've found it. I still won't condone the use of this drug in any manner. I certainly can't stop anyone from trying, and I'm sure many here will have important uses for this chemical. As always, tread carefully. We don't yet understand how this drug works, nor do we know of any potential interactions. What I'm doing no doubt has the potential to be very dangerous. I'm one of the few to have tried this research chemical, and the only one to report on Bluelight. Harm reduction advice regarding this substance is non-existent. As always, do as much research as possible before attempting to use this substance. Start low, pay very close attention to your mental state, and understand how you react before heading out into public. Only dose in a positive mental state - having the slightest negative thought prior to dosing has always ended badly for me. To avoid emotional amplification, I'd suggest combining with PRL 8-53. As far as the racetams go, I've only had the chance to try IDRA with Coluracetam - though the mental effects weren't unpleasant, this combination resulted in a massive headache. I doubt this is due to lack of choline, though it's certainly a possibility. If any other BL'ers have the chance to use this one, I'd very much like to know. I understand source discussion is not allowed here. However, I will say this - IDRA-21 is available at many of the major nootropics dealers. If you'd like further information, Longecity contains the most information regarding this chemical, including sourcing and anecdotal information. PubMed contains most of the studies relating to IDRA, and remains my most valuable and trusted source for studies of any type. Obvious information, perhaps, but a reminder never hurts.
Now, for my favourite overall nootropic, this would have to go to PRL 8-53 itself, briefly mentioned above and in my previous post on page 12. PRL 8-53 has significantly enhanced my memory retention (despite this being one of my strongest areas prior to using PRL.) Due to reports of tolerance, I restrict my use to 2 a maximum of 2 times per week. As with the racetams and nearly all nootropics, emotions are significantly blunted. I've noticed that, in using multiple days in a row, and this has been true for the racetams as well, my depression increases rather than decreases. Emotional blunting on its own causes me to become depressed. An important aspect I've noticed regarding my depression, perhaps applying to depression in general, is the lack of ability to express one's emotions. Suppressing emotions seems to be both a cause of depression and a way to intensify depression. I've always held the belief that one of the major causes of depression throughout the states is the lack of emotional expression promoted, especially seen in the workplace and at schools, for example. While this is nothing more than the subjective opinion of a single individual, I will give my opinion on the matter of treating depression through the use of nootropics, specifically the racetams. Given the emotional blunting seen with most racetams, I'm more inclined to recommend against the use of nootropics for depression - while it may blunt the emotions short-term, getting rid of some of the pain, emotional blunting, in my experience, has the potential to cause significantly greater long-term damage than depression on its own. Emotional blunting acts as little more than a short-term band-aid treatment, and far from the best short-term treatment. The key to treating depression I've found, is emotional openness - to re-experience the experiences and emotions that caused the depression, and to reframe the memories as a minor incident in order to move on. The only treatments I've found effective for depression are the dissociatives. Dissociatives, during their window of effect, have given me this distinct ability to "accept the unacceptable." I've accepted things, reframed memories that would otherwise seem impossible to accept. Even MDMA and LSD don't seem to carry this distinct effect, so says the homeless man living in the woods. While I wouldn't condone any sort of "criminal activity," I'd highly recommending using psychedelics as a treatment for depression over the nootropics. If one has any ability to obtain LSD or MDMA, one must come to their own conclusion as to whether or not to use such treatments in conjunction with an NMDA antagonist. While I cannot suggest the use of Ketamine, for example, without a prescription (which unfortunately, as of right now, would not be prescribed anyways, even as an off-label treatment), I can and will suggest healthy individuals to use a very low, daily dose of their dissociative of choice as a treatment for depression, if and only if said individual uses responsibly and practices HR to the highest of their knowledge and abilities. It is always important to keep in mind that a therapeutic dose will not necessarily carry the same risks as a recreational dose. Let's take DXM for example, being that I have the most experience with this one - DXM is neuroprotective at low-doses (Citation Removed - Unable to post links) but neurotoxic at high doses (I've been unable to find any studies relating to this subject; please feel free to correct me if I'm wrong here. In the interest of avoiding misinformation, take this purely as subjective information until further evidence proves or disproves this statement.) As far as subjective effects go, I've noticed nothing that might be termed as "psychedelic" at low doses, but all therapeutic benefits remain present. I am relieved of my depression and become more motivated to talk to others with significant relief of my social anxiety as well (mostly physical in my case, possibly related to the depression.) This was a bit off-topic, but I felt the need to comment here. Having suffered from depression for the last 12 years, I'm just now seeing relief in my use of dissociatives. While again, I'm no doctor, I'm very concerned about fellow sufferers of this condition. Given my (purely subjective) knowledge regarding depression, racetams are much more likely to do nothing for, or even worsen the extent of one's depression. Low-dose NMDA antagonists, including ketamine and newer compounds such as GLYX-13, have shown much greater evidence for relieving the symptoms of depression compared to the racetams (Citations removed - unable to post links).
In conclusion, my subjective thoughts are that the racetams lack the efficacy and reliability in treating depression comparative to the NMDA antagonists. For this reason, I cannot condone and, in fact, object to their use for the treatment of depression. As there are no studies I'm aware of directly comparing efficacy of an NMDA antagonist to any of the racetams in the treatment of depression, I'm forced to use strictly anecdotal evidence in comparing the two. Abuse, by which I refer to using an excessively higher dose than required to treat a given condition, can easily worsen depression in the racetams and especially in the use of dissociatives. Assuming one is not abusing any of the substances mentioned, there is no doubt in my mind that daily use of low-dose dissociatives will be superior both short-term and long-term in a higher percentage of individuals vs any of the racetams. Anecdotal evidence alone paints a sketchy picture for Piracetam as an antidepressant. Like the consistently unreliable SSRI's and tricyclic antidepressants, racetams tend to cause or worsen depression rather than treating it. Given the high percentage of responders to GLYX-13 in the study mentioned above, I cannot in good mind recommend the use of nootropics for the purpose of treating depression. Stick to the traditional use of cognitive enhancement, at least in the case of the racetams. Taking a look at these two studies (Citations removed - unable to post links), it's possible this lack of efficacy may be age-related. However, my being just 18 and failing to respond adequately to the racetams makes this theory unlikely to be relevant in humans. I've had little time to study this matter, but I understand acetylcholine to be closely involved in depression (if someone more educated than myself in this area has anything to add, I'd love to hear your thoughts.) Perhaps an acetylcholine defect is responsible for whether or not an individual will respond? Just a theory, and a weak one at that. More relevant studies need to be released before coming to a conclusion regarding racetams in the treatment of depression. For now, I'd steer clear. There are better options out there, at least in my opinion, as well as extensive experience. Hopefully this will help other users of this board to make a more educated decision regarding the treatment of their depression. I highly empathize with other individuals suffering from this condition, and I'd very much hate to see their condition worsen. We must always consider the best option for treatment, and racetams, based on the current evidence, are unfortunately not that option.
Speaking of which, I've been looking at NSI-189 and Cerebrolysin over this past year now. Anyone have any experience with these two? I plan on testing NSI in a few months time, and Cerebrolysin (intranasal) not long afterwards. I'll be sure to report soon after my trial is finished.
My most recent experiment involves mixing up Methylene Blue at a dose of 50ng (yes, that's nanograms) per drop. Many substances are still active at doses magnitudes lower than what is thought to be the lowest active dose, but with different mechanisms of action. I'm only aware of one other person ever to have dosed this low. Studies of this phenomenon can be found here, though nothing for Methylene Blue specifically currently exists in the scientific literature (Citation removed - unable to post links). Using this dose once per day, the bottle I'm currently using would theoretically last over 1500 years! Of course, the solution will expire long before then. Perhaps I'm better off getting pure powder from now on. I've mixed up a solution of 500ng per drop with a very obvious buzzing sensation in the head, but I'm dumping that one and using at a much lower dose for now. I'm a bit paranoid of using store-bought distilled water (Nestle, to be specific) due to the additional minerals added after the distillation process. Irrational paranoia or legitimate concern? In doing some reading, I’ve yet to see anyone mention anything more specific than “water” being used in the solution. Tap water, distilled water, bacteriostatic water? Not a single mention to date. Perhaps I’m just being overly careful here. Mind giving any input?
I've yet to try Coluracetam with any of the dissociatives. MXE is on the way, so I'll attempt this combination in 2 weeks and report back (without having tried MXE, I'll attempt to familiarize myself with the effects beforehand.) Piracetam didn't prevent my ability to hole on a 3rd plateau DXM trip, although Nicotine significantly potentiates dissociatives, in my experience. More likely the two cancelled each other out than anything.
Despite my general negativity towards IDRA in my last report, I have found it to be *very* useful in preventing the typical next-day stupidity from dissociatives and reversing all negative effects of Datura in regards to cognition. For this reason, it has become an invaluable part of my arsenal. Nothing so far has been able to achieve an immediate effect comparable to IDRA. I'd like to think Semax, Selank, NSI-189, and Cerebrolysin will be exceptions to this rule (and I'll soon be testing this theory.) For Alzheimer's and other cases of true cognitive deficiencies, I feel IDRA would be an excellent option. It's not to be used as a nootropic in the traditional sense, but used before, during, or after tripping, or in cases previously mentioned, IDRA has been extremely useful for me. In cases where it would otherwise be impossible to function the next day, IDRA reverses *all* noticeable effects on cognition and allows me to do what is needed. It's not an everyday option nor is it at all sustainable - I know I've said this before, but the point needs to be emphasized. In the end, I'm glad I've found a use for this incredible chemical rather than throwing out my batch over a few bad reactions. My opinion for IDRA hasn't changed, only expanded. Everything I've previously mentioned still holds true. I mentioned before that IDRA certainly had limited uses; until now, I was unable to determine what exactly those were - I'm now confident I've found it. I still won't condone the use of this drug in any manner. I certainly can't stop anyone from trying, and I'm sure many here will have important uses for this chemical. As always, tread carefully. We don't yet understand how this drug works, nor do we know of any potential interactions. What I'm doing no doubt has the potential to be very dangerous. I'm one of the few to have tried this research chemical, and the only one to report on Bluelight. Harm reduction advice regarding this substance is non-existent. As always, do as much research as possible before attempting to use this substance. Start low, pay very close attention to your mental state, and understand how you react before heading out into public. Only dose in a positive mental state - having the slightest negative thought prior to dosing has always ended badly for me. To avoid emotional amplification, I'd suggest combining with PRL 8-53. As far as the racetams go, I've only had the chance to try IDRA with Coluracetam - though the mental effects weren't unpleasant, this combination resulted in a massive headache. I doubt this is due to lack of choline, though it's certainly a possibility. If any other BL'ers have the chance to use this one, I'd very much like to know. I understand source discussion is not allowed here. However, I will say this - IDRA-21 is available at many of the major nootropics dealers. If you'd like further information, Longecity contains the most information regarding this chemical, including sourcing and anecdotal information. PubMed contains most of the studies relating to IDRA, and remains my most valuable and trusted source for studies of any type. Obvious information, perhaps, but a reminder never hurts.
Now, for my favourite overall nootropic, this would have to go to PRL 8-53 itself, briefly mentioned above and in my previous post on page 12. PRL 8-53 has significantly enhanced my memory retention (despite this being one of my strongest areas prior to using PRL.) Due to reports of tolerance, I restrict my use to 2 a maximum of 2 times per week. As with the racetams and nearly all nootropics, emotions are significantly blunted. I've noticed that, in using multiple days in a row, and this has been true for the racetams as well, my depression increases rather than decreases. Emotional blunting on its own causes me to become depressed. An important aspect I've noticed regarding my depression, perhaps applying to depression in general, is the lack of ability to express one's emotions. Suppressing emotions seems to be both a cause of depression and a way to intensify depression. I've always held the belief that one of the major causes of depression throughout the states is the lack of emotional expression promoted, especially seen in the workplace and at schools, for example. While this is nothing more than the subjective opinion of a single individual, I will give my opinion on the matter of treating depression through the use of nootropics, specifically the racetams. Given the emotional blunting seen with most racetams, I'm more inclined to recommend against the use of nootropics for depression - while it may blunt the emotions short-term, getting rid of some of the pain, emotional blunting, in my experience, has the potential to cause significantly greater long-term damage than depression on its own. Emotional blunting acts as little more than a short-term band-aid treatment, and far from the best short-term treatment. The key to treating depression I've found, is emotional openness - to re-experience the experiences and emotions that caused the depression, and to reframe the memories as a minor incident in order to move on. The only treatments I've found effective for depression are the dissociatives. Dissociatives, during their window of effect, have given me this distinct ability to "accept the unacceptable." I've accepted things, reframed memories that would otherwise seem impossible to accept. Even MDMA and LSD don't seem to carry this distinct effect, so says the homeless man living in the woods. While I wouldn't condone any sort of "criminal activity," I'd highly recommending using psychedelics as a treatment for depression over the nootropics. If one has any ability to obtain LSD or MDMA, one must come to their own conclusion as to whether or not to use such treatments in conjunction with an NMDA antagonist. While I cannot suggest the use of Ketamine, for example, without a prescription (which unfortunately, as of right now, would not be prescribed anyways, even as an off-label treatment), I can and will suggest healthy individuals to use a very low, daily dose of their dissociative of choice as a treatment for depression, if and only if said individual uses responsibly and practices HR to the highest of their knowledge and abilities. It is always important to keep in mind that a therapeutic dose will not necessarily carry the same risks as a recreational dose. Let's take DXM for example, being that I have the most experience with this one - DXM is neuroprotective at low-doses (Citation Removed - Unable to post links) but neurotoxic at high doses (I've been unable to find any studies relating to this subject; please feel free to correct me if I'm wrong here. In the interest of avoiding misinformation, take this purely as subjective information until further evidence proves or disproves this statement.) As far as subjective effects go, I've noticed nothing that might be termed as "psychedelic" at low doses, but all therapeutic benefits remain present. I am relieved of my depression and become more motivated to talk to others with significant relief of my social anxiety as well (mostly physical in my case, possibly related to the depression.) This was a bit off-topic, but I felt the need to comment here. Having suffered from depression for the last 12 years, I'm just now seeing relief in my use of dissociatives. While again, I'm no doctor, I'm very concerned about fellow sufferers of this condition. Given my (purely subjective) knowledge regarding depression, racetams are much more likely to do nothing for, or even worsen the extent of one's depression. Low-dose NMDA antagonists, including ketamine and newer compounds such as GLYX-13, have shown much greater evidence for relieving the symptoms of depression compared to the racetams (Citations removed - unable to post links).
In conclusion, my subjective thoughts are that the racetams lack the efficacy and reliability in treating depression comparative to the NMDA antagonists. For this reason, I cannot condone and, in fact, object to their use for the treatment of depression. As there are no studies I'm aware of directly comparing efficacy of an NMDA antagonist to any of the racetams in the treatment of depression, I'm forced to use strictly anecdotal evidence in comparing the two. Abuse, by which I refer to using an excessively higher dose than required to treat a given condition, can easily worsen depression in the racetams and especially in the use of dissociatives. Assuming one is not abusing any of the substances mentioned, there is no doubt in my mind that daily use of low-dose dissociatives will be superior both short-term and long-term in a higher percentage of individuals vs any of the racetams. Anecdotal evidence alone paints a sketchy picture for Piracetam as an antidepressant. Like the consistently unreliable SSRI's and tricyclic antidepressants, racetams tend to cause or worsen depression rather than treating it. Given the high percentage of responders to GLYX-13 in the study mentioned above, I cannot in good mind recommend the use of nootropics for the purpose of treating depression. Stick to the traditional use of cognitive enhancement, at least in the case of the racetams. Taking a look at these two studies (Citations removed - unable to post links), it's possible this lack of efficacy may be age-related. However, my being just 18 and failing to respond adequately to the racetams makes this theory unlikely to be relevant in humans. I've had little time to study this matter, but I understand acetylcholine to be closely involved in depression (if someone more educated than myself in this area has anything to add, I'd love to hear your thoughts.) Perhaps an acetylcholine defect is responsible for whether or not an individual will respond? Just a theory, and a weak one at that. More relevant studies need to be released before coming to a conclusion regarding racetams in the treatment of depression. For now, I'd steer clear. There are better options out there, at least in my opinion, as well as extensive experience. Hopefully this will help other users of this board to make a more educated decision regarding the treatment of their depression. I highly empathize with other individuals suffering from this condition, and I'd very much hate to see their condition worsen. We must always consider the best option for treatment, and racetams, based on the current evidence, are unfortunately not that option.
Speaking of which, I've been looking at NSI-189 and Cerebrolysin over this past year now. Anyone have any experience with these two? I plan on testing NSI in a few months time, and Cerebrolysin (intranasal) not long afterwards. I'll be sure to report soon after my trial is finished.
My most recent experiment involves mixing up Methylene Blue at a dose of 50ng (yes, that's nanograms) per drop. Many substances are still active at doses magnitudes lower than what is thought to be the lowest active dose, but with different mechanisms of action. I'm only aware of one other person ever to have dosed this low. Studies of this phenomenon can be found here, though nothing for Methylene Blue specifically currently exists in the scientific literature (Citation removed - unable to post links). Using this dose once per day, the bottle I'm currently using would theoretically last over 1500 years! Of course, the solution will expire long before then. Perhaps I'm better off getting pure powder from now on. I've mixed up a solution of 500ng per drop with a very obvious buzzing sensation in the head, but I'm dumping that one and using at a much lower dose for now. I'm a bit paranoid of using store-bought distilled water (Nestle, to be specific) due to the additional minerals added after the distillation process. Irrational paranoia or legitimate concern? In doing some reading, I’ve yet to see anyone mention anything more specific than “water” being used in the solution. Tap water, distilled water, bacteriostatic water? Not a single mention to date. Perhaps I’m just being overly careful here. Mind giving any input?
Xorkoth
Bluelight Crew
Someone was taking multiple KILOS of piracetam DAILY? That's completely insane. 
any major dude
Bluelight Crew
About to start up another round of nootropic experimentation in preparation for some grad school stuff. I've got pramiracetam, aniracetam, coluracetam, noopept, & citicholine. Contemplating acquiring some phenylpiracetam & huperzine A as well. Gonna start out with lower dosages this time as I found my previous stack a bit agitating. Any notable contraindications here? The only other drugs I take with any frequency are caffeine, modafinil, cannabis, diphenhydramine, & etizolam.
Any suggestions/commentary are welcome also
Any suggestions/commentary are welcome also
angeleyes
Bluelight Crew
I'm keen as to hear your findings on these, good luck may the force and the racetams be with you 
Which ones are you going to start with first?
Which ones are you going to start with first?
SkyblueMolly
Bluelighter
Has anyone tried fluorenol? It's supposed to be a potent wakefulness enhancer.
Ekscentra
Bluelighter
- Joined
- Feb 20, 2014
- Messages
- 53
@Katuskoti
Tolerance problems with Phenylpiracetam are a commonly reported issue, even after a single dose. Have you noticed anything in this area? How frequently do you use your nootropic stack, typically? I've had a great interest with Phenylpiracetam, mainly due to my chronic lack of motivation (I am, after all, posting on a forum during school rather than doing work...) Reports of tolerance have been the only thing keeping me away. I wonder if perhaps Methylene Blue and a low-dose of D-Amphetamine (prescribed for my ADD) might be able to mediate this.
On another note, I've had a great interest in Unifiram lately. Has anyone had a chance to test this one? Reports on any of the racerams would be interesting, as I haven't seen any reports pop up in this thread regarding these substances. Sunifiram, perhaps? I'm avoiding Suni and Noopept due to the skin-drying effects of those two; I'm afraid I'll have to sit this one out. Otherwise, Sunifiram looks like a truly incredible substance, from the many reports I've read on Longecity, Unifiram much more so. I'm surprised to be the only one testing some of the more obscure nootropics around here. Aside from Selank, this thread is devoid of the lesser-known nootropics out there. What happened to all you lab rats out there?
Better get to work! (With caution, as always. )
Edit: Something I forgot to address in my post above - with regards to sleep, I've definitely noticed difficulty sleeping after using Piracetam, regardless of the time of dose. This only occurs after using for 3 or more days in a row, so I've confined my use to once or twice per week maximum, always spaced out as necessary. PRL 8-53 is even worse, due to its subtle but obvious stimulant properties - dosing late at night always keeps me up. My insomnia (Primary Sleep Onset Insomnia, to be precise) already requires 8-10 hours of rest prior to sleeping. PRL kills any possibility of getting to sleep that night, with the exception of antihistamines, of course. I haven't tried any barbs, benzos, or other hypnotic substances to prevent this, but I have no reason to dose at night anyways, aside from my bi-weekly (that's twice a month, not twice a week) dissociative trips (of course, I'd never do anything illegal, hehe.) I haven't noticed anything in this area with Coluracetam, though I wasn't looking. IDRA had no negative effect on sleep whatsoever, nor did anything else I've mentioned, as far as nootropics go.
Tolerance problems with Phenylpiracetam are a commonly reported issue, even after a single dose. Have you noticed anything in this area? How frequently do you use your nootropic stack, typically? I've had a great interest with Phenylpiracetam, mainly due to my chronic lack of motivation (I am, after all, posting on a forum during school rather than doing work...) Reports of tolerance have been the only thing keeping me away. I wonder if perhaps Methylene Blue and a low-dose of D-Amphetamine (prescribed for my ADD) might be able to mediate this.
On another note, I've had a great interest in Unifiram lately. Has anyone had a chance to test this one? Reports on any of the racerams would be interesting, as I haven't seen any reports pop up in this thread regarding these substances. Sunifiram, perhaps? I'm avoiding Suni and Noopept due to the skin-drying effects of those two; I'm afraid I'll have to sit this one out. Otherwise, Sunifiram looks like a truly incredible substance, from the many reports I've read on Longecity, Unifiram much more so. I'm surprised to be the only one testing some of the more obscure nootropics around here. Aside from Selank, this thread is devoid of the lesser-known nootropics out there. What happened to all you lab rats out there?
Better get to work! (With caution, as always. )Edit: Something I forgot to address in my post above - with regards to sleep, I've definitely noticed difficulty sleeping after using Piracetam, regardless of the time of dose. This only occurs after using for 3 or more days in a row, so I've confined my use to once or twice per week maximum, always spaced out as necessary. PRL 8-53 is even worse, due to its subtle but obvious stimulant properties - dosing late at night always keeps me up. My insomnia (Primary Sleep Onset Insomnia, to be precise) already requires 8-10 hours of rest prior to sleeping. PRL kills any possibility of getting to sleep that night, with the exception of antihistamines, of course. I haven't tried any barbs, benzos, or other hypnotic substances to prevent this, but I have no reason to dose at night anyways, aside from my bi-weekly (that's twice a month, not twice a week) dissociative trips (of course, I'd never do anything illegal, hehe.) I haven't noticed anything in this area with Coluracetam, though I wasn't looking. IDRA had no negative effect on sleep whatsoever, nor did anything else I've mentioned, as far as nootropics go.
Last edited:
Xorkoth
Bluelight Crew
Wow, just looked up methylene blue because I had no idea what it was... I read that it can be used to treat resistant plaque psoriasis, which I have. Very interesting. Can anyone describe their experience using it, for any purpose?
Pira wiki said:
Hmmm, iiinteresting!
Also, check galantamine, it also lists the following:
Someone was taking multiple KILOS of piracetam DAILY? That's completely insane.
WTF?! Where are you reading this? I can't really find it... seems molto incroyable..
Also about the methylene blue, does it dye your mouth like etizolam pills can when you take them sublingually?
I have blue food dye but unfortunately it is not methylene blue but patent blue V instead, which can be harmful instead of beneficial. Why?! Stupid asian mini market
Any Major Dude said:
@AMD: Which of those racetams are you planning on taking regularly / daily? Are you just trying them to see which is best to continue with?
You will probably want to finetune / limit your intake of noopept, phenylpiracetam, caffeine and modafinil if you want to avoid agitation / irritation and hyperactive feelings until late in the evening. Noopept has been linked to agitation and irritation... phenylpiracetam is said to be stimulating, and the vigilance / wakefulness promotion from caffeine and modafinil possibly synergizes to increase all those effects.
Also it may just be a little overkill since there is some redundancy, that's why I recommend picking and choosing which one is ideal for which situation and which is just more effective. Modafinil is just superior to caffeine IMO (though the effects of caffeine can be improved by adding theanine), but it may not be cheap to take modafinil all the time.
I forgot about huperzine A (if I had to recall I'd guess that it is a cholinesterase inhibitor?). There was something slightly tricky about it, I remember that much. Let me look it up.
edit: About the cholinesterase inhibition, that much is true. Which by the way galantamine is as well...
Is there such a thing as choline syndrome? I've heard that term actually, kinda recently - but I am not sure if it is in any way comparable to serotonin syndrome as concepts. The context was also different...
Reading about cholinesterase inhibitors it appears that getting entirely too much choline can indeed have toxic effects, especially if they drug involved is of the quasi-irreversible kind. That would make the potential a lot more 'unlimited'. But, if people are combining these with cholinergic drugs I wonder what kind of regimen would involve contraindications.
Adding racetams doesn't seem extra risky, on the contrary: if the racetam can support conversion of choline (at increased levels) to acetylcholine, this could be attenuating. But I imagine acetylcholine levels going off the charts isn't particularly healthy either, so the question is whether the body knows when to stop [making use of supplemented choline in the form of precursors] when there are a lot of "encouraging" cholinergic drugs acting.
Is it possible that in those situations choline precursors are considerably safer than "instant" choline ingested as some salt?
Last edited:
Draven26
Bluelighter
Out of PRL-8-53, phenylpiracetam, and noopept.. which will help with energy levels the most!? I've taken phenylpiracetam.. it was so so.. nothing major! Was looking for something to take preworkout.. which of those three would be best?
Draven26
Bluelighter
Oh and I've tried Oxiracetam at high doses and I didn't feel a thing on that and a lot of people said it was highly stimulating. I guess I just don't respond to nootropics =/
Why would cognitive enhancers help with your workout? Sure you can put certain drug 'action' under the nomer 'activating' / stimulating and phenylpiracetam is said to be mildly stimulating (oxiracetam also), but not sure if any of these work on 'energy levels' in a way that is relevant to the context of working out. So can you elaborate on that?
I'd say creatine is a good pre workout supplement, by the way. Maybe CoQ10, which actually is directly involved with energy (mitochondrial ATP) maintenance in the body and it is also apparently good for the heart? B vitamins like B6 I guess...
I don't think oxiracetam is really stimulating like actual stimulants are, it is only by comparison that it may be a pushy kind of lucid that aniracetam perhaps is not... but other than that I think you are misunderstanding what nootropics are and what they can be used for (noopept for brain recovery, also maybe learning and memory - racetams learning and memory, also some may work as adaptagen). For a workout you need different stuff.
Draven26
Bluelighter
Because a few of the gym rats were making it seem like nootropics are great for working out and as a replacement for adderall which I definitely think is pushing it. A couple of bodybuilders have said phenylpiracetam is probably the best for cardio sessions and gets you through a workout and I've used that but I just wanted to know if nootropics were anything like stimulants and I figure they were not so I just wanted to clarify. I would personally try rc stimulants but I live in California and I don't want to risk them being seized if I buy any online.. I know the laws are pretty strict in the states so.. anywho thank you for your input!
Taking amphetamines to work out does not seem reasonable to begin with (I would believe that muscle regeneration is not that great on amps, even if it motivated you to do a lot of reps) and it seems that the reasons for doing that are not really present in nootropics, they are just not pushy enough.
RC stims, come on man... what are you trying to achieve? Stick to creatine, proteins, carbs....
RC stims, come on man... what are you trying to achieve? Stick to creatine, proteins, carbs....
Xorkoth
Bluelight Crew
Solipsis said:
It was here, a few posts up, the really long one.
Ekscentra said:
Incunabula
Bluelighter
- Joined
- Dec 10, 2010
- Messages
- 1,861
Thanks, yeah, I've been taking coluracetam for 2 weeks now, and I don't feel it interferes with my sleep in anyway at all, Luckily. Could you tell some more about IDRA-21, I mean how it affects you?
I think it's a huge draw back for a nootropic to some how interfere with sleep. It's kind of counterproductive imo. And since I have extremely vivid dreams without taking anything, I'd like to avoid anything that can make it worse.
If anybody else would like to comment what effects different nootropics have on their sleep, please do tell. I don't only mean if dosing in the day make it hard to go to bed in the evening, but also how it effects the quality of sleep, dreams etc.
Ekscentra
Bluelighter
- Joined
- Feb 20, 2014
- Messages
- 53
My experiences with IDRA were posted earlier in this thread, on page 12.
After further testing IDRA in combination with dissociatives, I've noticed something further regarding its effects on emotions - IDRA not only amplifies emotions, but, in the case of NMDA antagonists (and possibly SSRIs as well, DXM being both an SSRI and NMDA receptor antagonist; extremely difficult to separate the effects, however), the absence of emotion is amplified as well. Strangely enough, this same effect does not present itself with other emotionally-numbing substances - PRL and the racetams seem to cancel out the emotional amplification of IDRA, and vice-versa for IDRA and the emotional numbing of these two. I can't even speculate as to why this would be the case.
I have noticed some type of cognitive enhancement using IDRA other than what I've already mentioned, but I can't seem to pinpoint just what is being enhanced. As mentioned, it's much more suitable for the purpose of restoring cognition, whether drug-induced or sleep deprivation. IDRA has allowed me to function at 100% of my capabilities, and perhaps even beyond this level, in situations where it would otherwise be impossible. For this purpose, it's been invaluable to me. Still, it can be very sensitive to set and setting on its own. Stressful situations still carry the possibility of some type of mania or psychosis occurring, but this is a rare occurrence in only to be considered in the most extreme situations, and, as I said before, this can be counteracted by any of the emotionally-numbing nootropics. The only negative interaction I've experienced thus far was with Coluracetam, which resulted in a massive headache 8 hours after administration; no other negative effects presented themselves and this effect faded after just a few hours, so it's doubtful this was anything particularly dangerous. It was a mentally pleasant combination aside from this, and worked pretty well for those initial 8 hours. Choline depletion, possibly? Having said that, everything else I've used, including Piracetam (worth mentioning due to similar MOAs), has resulted in no negative effects. The safety profile seems fairly promising so far - while this is only one individual's experience, I've combined IDRA with multiple antihistamines, dissociatives, racetams, PRL, nicotine, amphetamines, guanfacine, acetaminophen, and various supplements with no negative changes to note (I haven't taken any objective measurements, however.) Take that for what it's worth.
After further testing IDRA in combination with dissociatives, I've noticed something further regarding its effects on emotions - IDRA not only amplifies emotions, but, in the case of NMDA antagonists (and possibly SSRIs as well, DXM being both an SSRI and NMDA receptor antagonist; extremely difficult to separate the effects, however), the absence of emotion is amplified as well. Strangely enough, this same effect does not present itself with other emotionally-numbing substances - PRL and the racetams seem to cancel out the emotional amplification of IDRA, and vice-versa for IDRA and the emotional numbing of these two. I can't even speculate as to why this would be the case.
I have noticed some type of cognitive enhancement using IDRA other than what I've already mentioned, but I can't seem to pinpoint just what is being enhanced. As mentioned, it's much more suitable for the purpose of restoring cognition, whether drug-induced or sleep deprivation. IDRA has allowed me to function at 100% of my capabilities, and perhaps even beyond this level, in situations where it would otherwise be impossible. For this purpose, it's been invaluable to me. Still, it can be very sensitive to set and setting on its own. Stressful situations still carry the possibility of some type of mania or psychosis occurring, but this is a rare occurrence in only to be considered in the most extreme situations, and, as I said before, this can be counteracted by any of the emotionally-numbing nootropics. The only negative interaction I've experienced thus far was with Coluracetam, which resulted in a massive headache 8 hours after administration; no other negative effects presented themselves and this effect faded after just a few hours, so it's doubtful this was anything particularly dangerous. It was a mentally pleasant combination aside from this, and worked pretty well for those initial 8 hours. Choline depletion, possibly? Having said that, everything else I've used, including Piracetam (worth mentioning due to similar MOAs), has resulted in no negative effects. The safety profile seems fairly promising so far - while this is only one individual's experience, I've combined IDRA with multiple antihistamines, dissociatives, racetams, PRL, nicotine, amphetamines, guanfacine, acetaminophen, and various supplements with no negative changes to note (I haven't taken any objective measurements, however.) Take that for what it's worth.
Xorkoth
Bluelight Crew
Thanks for reporting. I am extremely interested in nootropics, and IDRA wasn't even on my radar. So I have a question. What sort of effect does it have on the experience of psychedelics? I know that for me, piracetam can affect the intensity of a trip, though it doesn't always. And piracetam and the like seems to greatly diminish the effects of dissociatives, though I haven't combined them myself.
I am extremely interested in nootropics, and IDRA wasn't even on my radar. So I have a question. What sort of effect does it have on the experience of psychedelics? I know that for me, piracetam can affect the intensity of a trip, though it doesn't always. And piracetam and the like seems to greatly diminish the effects of dissociatives, though I haven't combined them myself.