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Memantine is a synthetic dissociative compound from the adamantane class, primarily known as an NMDA receptor antagonist. While it is medically used in the treatment of moderate to severe Alzheimer's disease, it is occasionally used recreationally for its long-lasting dissociative effects.
Dosage and Effects at Recreational Use (~100 mg)
An oral dose of 70–110 mg is considered common in recreational contexts. At this level, the following effects may occur:
- Physical:
A sense of bodily lightness, increased control over body movements, stimulation, appetite suppression, nausea, pain relief, constipation, difficulty urinating, dizziness, headache, increased heart rate, and visual distortions.
- Visual:
Color enhancement, sharper visual acuity, afterimages, changes in depth perception, environmental distortions, and hallucinations.
- Cognitive:
Cognitive euphoria, conceptual thinking, time distortion, enhanced creativity, deeper appreciation for music, increased motivation, reduced anxiety, disinhibition, suppression of dreams and memory, and slowed thoughts.
The effects typically begin within 30 to 180 minutes after ingestion, peak between 3 to 12 hours, and can last up to 36 hours, followed by an afterglow lasting 8 to 24 hours.
Risks and Side Effects
At higher doses, more serious side effects may occur, including hallucinations, confusion, drowsiness, dizziness, agitation, aggression, and impaired motor function. In extreme cases, such as doses around 2000 mg, coma and long-lasting neurological symptoms have been reported.
Memantine has a long half-life (60–100 hours), meaning it remains in the body for an extended period. This increases the risk of cumulative effects with repeated use. It may also interact with other NMDA antagonists (like amantadine, ketamine, or dextromethorphan), heightening the risk of adverse effects.
Conclusion
While memantine can produce dissociative and hallucinogenic experiences at recreational doses, it carries significant risks—especially at higher levels. Its long duration of action and potential for interaction with other substances make it complex and potentially dangerous to use non-medically. Caution and awareness of these effects are essential.
