Hi,
nobody mentionned the fact that Nichols often talked about AL-LAD (example:
https://www.youtube.com/watch?feature=player_detailpage&v=ZJtdZUy1LYE#t=2393s table around 40 minutes) always mentioning the fact that the active dose really seems to be higher than that of LSD-25 (in my link: 110% the potency of LSD-25 in humans, 285% (!) in rats). Even Shulgin seems to argue in favor of that idea with his dosage range of 80 to 160 µg (against 60-200 µg for LSD-25).
And yet the latest TR seem to view this batch as weaker than your regular lucy. Call me paranoid but I find this suspicious...
About the dosage discrepancies
First, Shulgin has been wrong before, at the top of my head allylescaline and escaline comes to mind. Most people found these to be less potent than Shulgin reported. I think there's several reasons for this, one being that some of the chems he made wasn't ever trialed
that many times, by
that many people, making the recommended dosages in pihkal and tihkal quite subjective for some of the chems. And also making the dosage recommendations susceptible to Shulgins own set and setting.
Another example is 4-ho-met which he describes as "Qualitatively a lot like psilocin" which is just so absolutely completely wrong, in my opinion, 4-ho-met is NOTHING like psilocin.
And Nichols, He's a legitimate researcher. he doesn't do in vivo testing (although I've heard him allude of having tasted psychedelic drugs in the past) but tests the potency of drugs in drug discrimination tests on rats. I don't see were he can have the information from that AL-LAD should be 10 % stronger than LSD in humans. It would be illegal of him to give psychedelics to humans without special permission, so that info must be second hand. Don't get me wrong, I have huge respect for Nichols and I know that he knows what he's talking about, but.......
And nother thing is, how can some one compare two drugs that do actually have subjectively slightly different effects. And say that one is 10 % more potent? If AL-LAD feels more calm and is less visual than LSD, it can also
feel less potent. Even though science says it should be more potent.
in vitro rat tests just doen't hold up to in vivo! in my opinion. And Ki values and all that stuff just means fuck all in the end, if you ask me.
I find it logical that lengthening the methyl of LSD to not only ethyl, but propyl with a double binding (allyl) to cause a drop in potency because of the bulkyness of the group. It's very rare in psychedelic pharmacology that potency goes up when a carbon chain is lengthened. (or what? correct me if I'm wrong here

)
In the case of LSZ, I can understand why it should be more potent than LSD, because the 2 ethyl "antlers" have been locked in place by the azetidine wrong, so more/all molecules will fit snuggly into the receptor. What we still need to see though, is wether it is actually subjectively better than LSD, which I am actually doubtfull about.
Besides that, there can be several reasons the blotters have subjectively been found to not be as strong as we
might have expected:
- The dose in the blotters might actually be lower than 150 ug. Also we don't know the purity of the AL-LAD (as far as I know) which means that if it's less pure than the chemist thought, the blotters will end up containing less AL-LAD than they were aiming at. But it's still AL-LAD.
- The salt form? We don't know which salt form it is. (I find 2C-B HCl A LOT more potent than 2C-B HBr for instance. And I find it to have a lot quicker onset as well)
- Set and setting of the people who tried it so far ( as Si ingwe already mentioned)
actually. Reading Shulgin's AL-LAD page in TIHKAL again, I really don't find it that far off from my own findings with it.
Qualitatively, how similar is this stuff to acid? I recently tripped for the first time on LSD and wasn't too impressed. Maybe something with a shorter duration would be better.
Will probably wait until this chem gets more established before diving in. Just curious
It's subjectively very similar to LSD. The difference is in the detail, and in the onset and duration.
LSD is by far the best psychedelic ever created though, you just need to try it again, probably at a higher dose
