When I do test it I want to do it in the best way possible... so I'll make sure I quite hydrated days ahead and the day of, empty stomach for a least 4 hours before ingestion, have a well balanced meal early in the day (I'll avoid food with any MAOIs), supplements/vitamins, 8 hours of sleep, etc. I've just been in a weird spot recently with my personal life so that's why I've held back on doing it already, but I feel like I'm back in a good spot again so I'm giving myself the green light. I'll also have a close friend of mine trip sitting in case anything does go wrong, and if it does either he or myself will report back here as soon as possible with details in hopes of helping others who read this. I also have a small stash of benzos on hand that I only use for bad trips so I will keep that close as well (if mixing benzos with this is a bad idea please let me know).
The only thing that I am unsure of at the moment is the dosage. I have already done the allergy test and there was no problems. I'm just worried that I might take too much but at the same time I don't want to take too little (you can always take more but you can never take less). I won't redose because I feel that like a tolerance might be built and would screw up my results. I feel like 20mg might be a good starting point but I also want to hear what others might think.
Sounds like you've got a great plan there, can't wait to hear how it all turns out!
Also, to my knowledge benzos are generally not unsafe to mix with MAOIs, but you should probably at least do a couple quick web searches for the one you intend to use specifically to make sure that still applies to it.
As for the dose.... First of all, I feel I should point out that you probably also shouldn't redose for another reason: it could be, for instance, that 4-HO-McPT is not a MAOI but just a regular substrate that is metabolized into a MAOI, which would mean that if you spaced out the doses the successive doses would actually be increasingly more potent by weight than the first one. This is obviously not a good way to collect solid information on a brand new substance, nor is it really that safe of a possibility to take too many risks with at this point. So, yeah, I definitely think you should stick with that logic for whatever reason and not redose for now.
For a single dose, my best guess would be that 20 mg probably won't be too out of control. I'd feel comfortable starting at 25 mg myself, as I probably will, but I wouldn't go over that much for now. I probably wouldn't go under 20 mg either or I feel I'd risk being underwhelmed, but that is just based on my personal experience with other members of this chemical class, whereas for example I know someone who goes out of their mind on 15 mg of 4-HO-MiPT, so they would obviously be better off starting with a different kind of dose.
In Tranylcypromine ("Parnate"), the cyclopropyl group does indeed lead to Irreversible MAO Inhibition. However, the cyclopropyl in that drug is sandwiched between the Phenyl and the amine (it's essentially just amphetamine with the ethyl and alpha-methyl groups fused into a cyclopropyl ring). With 4-HO-McPT, on the other hand, the cyclopropyl is only connected to the terminal amine, so maybe it could get dealkylated/deaminated without permanently gumming up the enzyme.
As for DNA damage - there is a number of prescription pharmaceuticals with cyclopropyl groups attached to them that would probably have been taken off the market already if they were carcinogenic in any significant way; Prazepam, for one, comes to mind. Since the average psychonaut probably isn't going to ingest more than one-hundred miligrams of 4-HO-McPT in a month, I kind of doubt you're exposing yourself to a major cancer risk with it either.
I've been trying to do a little bit of reading on the monoamine oxidase inhibitory properties of cyclopropylamines when I can, and it does seem like there's some variance, and it makes me want to be more cautious that 4-HO-McPT could be an irreversible inhibitor as well. Though, notably, I did find one saying that NcPT and 7-MeO-NcPT successfully inhibited the metabolism of serotonin whereas 5-MeO-NcPT did not, so I wonder if the 4-HO substitution being on the same side of the ring will also disrupt activity there? It's worth noting as well that a few of these studies that ascribe irreversible inhibitory properties to some of these cyclopropyl molecules actually also say that the corresponding isopropyl versions are reversible inhibitors, so it may be worth considering that if there were going to be any serious issues we might have already noticed them with 4-HO-MiPT. Lots of things to consider....
Thanks for pointing out the prazepam too, I was really wondering what some of the supposed pharmaceuticals containing cyclopropyl groups might be. That definitely does give me some more confidence with it.
Oh this is out...that it might be similar potency to 4HO-MIPT 'might' be correct since 25mg MIPT was mild and 20mg of McPT was at the point where I thought it was more than placebo but wasn’t entirely sure. I agreed with the original report that 40mg of McPT is more like a dose but not with them likening it to MIPT in effect; it was very different
Thanks for the input, very interesting that you were able to try McPT as well. Would you mind expanding just a little bit on what makes it different from MiPT?