Potency for 3-HO-PCE is in the same range as PCE and O-PCE. 2mg-15mg (for non-tolerant users) I kept redosing so I am not able to give you any information about duration. By the way identity of said compound was confirmed via independent NMR spectroscopy, so anyone who needed 60mg for effects did not take 3-HO-PCE! Another concern for me is the suspected opioid activity. I know this was speculated about MXE, 3-MeO-PCP and 3-MeO-PCE which I never understood.. Neither of these let me to believe that that there is opioidergic activity. But 3-HO-PCE was different. (Please keep in mind that speculation about actual physiological targets using subjective experiences as evidence is highly unreliable..) Experiments took place about 1.5 months after quitting a year long fentanyl binge, so my memories of opioid effects were still fresh.. Based on my experiences with other arylcyclohexylamines I did not expect it to have opioidergic effects but was pleasantly surprised a few minutes after taking the first 5mg.. Dissociative effects were also present.. So this was the first indication of opiodergic activity.. But I noticed something else which strengthened this idea.. Well I've actually got mild cravings when effects decreased and next morning right after waking up I felt and followed a strong urge to dose it again.. I have never experienced anything like this with any other dissociative I've tried and 3-MeO-PCP is my alltime favourite drug (along with LSD )! So please keep the possibility in mind. Respiratory depression and dissociative mania could be a dangerous combination..