The Big and Dandy NBOMe-2C-C (25C-NBOMe) Thread

[any major dude]

I put my solution onto blotter paper then let that sit in my mouth for about 15 minutes. Before this I brushed my teeth thoroughly.

thanks for the info. So that worked pretty well then?

jesus just breathing in the same room as that drug would scare me. :O

yeah, i'm a tad nervous about handling this one as well, but want to try something new, so I may.... still debating it though.

Source is probably from Nichols / Purdue group's work isn't it?

I believe so. Regardless, they were the first to start tacking NBOMe onto various PEA's.

 

[atara]

Not really on-topic but I saw there is a NBOMe version of TCB-2 a.k.a 2CBCB (2C-B CycloButane analogue) which is extremely potent in itself.
The NBOMe version of that: 2CBCB-NBOMe must be ridiculously (dangerously) potent. Even significantly more than LSD. That's all logically derived theory though, it might very well not follow those rules of extrapolation.

Its Ki isn't much lower than 25B's. It's similar to the combination of carfentanil and 3-methylfentanyl, which gives you lofentanil: the increase from carfentanil to lofentanil is not as big as the increase from fentanyl to 3-methylfentanyl.

I would like to see an NBOMe-Jimscaline, just on the off-chance it shares the magic of mescaline at a significantly increased potency.

 

[any major dude]

now there's an idea. though i'd like to try jimscaline proper first...

 

[nuke]

The real gem from this series in terms of potency is most likely 2-(4-Chloro-2,5-dimethoxyphenyl)-N-[(2,3-methylenedioxyphenyl)methyl]ethanamine... The iodinated derivate is quite a bit more potent in terms of affinity than even LSD at the 5HT2A receptor.

 

[Solipsis]

Ah yes I encountered that one, the 25X-NBMD 'series' ?
What I was wondering - if I may turn this thread into ADD for a minute - is if it would be expected that this molecule functions as a sort of dimer of 2C-X and MDMA. If I am not mistaken seen from the right the complete skeleton is in there right? So is it not equally MDMA with a 2C-X moiety as well as the other way around?
edit: oops no I see that that it's missing a beta carbon... what about if it had that:

2-(4-Halo-2,5-dimethoxyphenyl)-N-[(2,3-methylenedioxyphenyl)ethyl]ethanamine

 

[atara]

Ah yes I encountered that one, the 25X-NBMD 'series' ?
What I was wondering - if I may turn this thread into ADD for a minute - is if it would be expected that this molecule functions as a sort of dimer of 2C-X and MDMA.

Problem: even if it were metabolized to MDMA, that adds up to a whopping 30 micrograms of MDMA per dose. Not gonna do much.

And there aren't enough carbons there for the whole MDMA "skeleton".

 

[MattPsy]

I believe so. Regardless, they were the first to start tacking NBOMe onto various PEA's.

Not so, not so. There is a thesis by a German fellow, as well. Already been mentioned in this or the thread linked to by Erny. It's even referenced on the Wikipedia page (see below). Perhaps people don't read, afterall .

invert: "Ah, okay, it's a PhD thesis, not a paper... that makes it a bit trickier to check. *tries various access methods* Hmm, well I don't think I have access to it. "

You do realise that the Wikipedia page(s) about these compounds link directly to the access page for the sections of that very thesis, right? And that they open if you simply then click on the link of the section you wish to read? No special access required.

 

[invert]

You do realise that the Wikipedia page(s) about these compounds link directly to the access page for the sections of that very thesis, right? And that they open if you simply then click on the link of the section you wish to read? No special access required.

D'oh! :D It was my browser blocking cookies that was preventing it from opening. Cheers!

 

[pharmakos]

eh, the stuff on the "other" side of the nitrogen is pretty different from MDMA.

the methyl connecting the methylenedioxyphenyl to the nitrogen would have to be extended to a longer chain, as you said. to make it truly an MDMA molecule over there, however, the methyl would have to be extended to an isopropyl, and the methylenedioxy would have to be moved one position further away from that isopropyl, to the 3,4 position i believe.

 

[ebola?]

SAR speculation on n-BOMe-3,4-MDPEA:

IIRC, the expectation is that this should be an active compound, the n- substitution throwing a wrench into the prohibitively rapid metabolism of MDPEA. On the other hand, because this n-substitution doesn't seem to drastically enhance affinity for SERT, but enhances affinity for 5ht2a by a great deal, maybe we'd have more of a classical psychedelic, without entactogenesis.

So would this be barking up the wrong tree, an unknown tree, or a promising tree?

ebola

 

[pharmakos]

as always, it's an unknown tree until someone actually finds an active level of the stuff.

 

[atara]

SAR speculation on n-BOMe-3,4-MDPEA:

IIRC, the expectation is that this should be an active compound, the n- substitution throwing a wrench into the prohibitively rapid metabolism of MDPEA. On the other hand, because this n-substitution doesn't seem to drastically enhance affinity for SERT, but enhances affinity for 5ht2a by a great deal, maybe we'd have more of a classical psychedelic, without entactogenesis.

So would this be barking up the wrong tree, an unknown tree, or a promising tree?

ebola

The methylenedioxy substitution seems to do other interesting things besides 5ht release. In particular, MMDA-2 has very low SERT affinity but still displays MDA-like effects, with Shulgin saying "it would be impossible for anyone at this level, on this compound, to have a bad experience".

So a promising tree.

 

[ebola?]

Off-topic:
Another experiment for close auto-supervision is mdpea + inhibition of mao-b.

 

[nuke]

Ah yes I encountered that one, the 25X-NBMD 'series' ?
What I was wondering - if I may turn this thread into ADD for a minute - is if it would be expected that this molecule functions as a sort of dimer of 2C-X and MDMA. If I am not mistaken seen from the right the complete skeleton is in there right? So is it not equally MDMA with a 2C-X moiety as well as the other way around?
edit: oops no I see that that it's missing a beta carbon... what about if it had that:

2-(4-Halo-2,5-dimethoxyphenyl)-N-[(2,3-methylenedioxyphenyl)ethyl]ethanamine

No, not at all really... It's mostly just a really high affinity 5HT2A ligand. If you extend the carbon chain, my guess is the activity will go down, but I'm not completely sure. It's probably best left as is if you're looking for potency.

 

[Erny]

The real gem from this series in terms of potency is most likely 2-(4-Chloro-2,5-dimethoxyphenyl)-N-[(2,3-methylenedioxyphenyl)methyl]ethanamine... The iodinated derivate is quite a bit more potent in terms of affinity than even LSD at the 5HT2A receptor.

Iodinated derivative is much less active than usual 2-methoxybenzyl, but chloro may still be nice, for a different reason. 2,3-NBMD-2C-I seem to retain all the qulities of the 2-methoxy derivative, which is quite behind all of them, chloro, bromo, alkyls, etc, and is the most enjoable of them all for many people. Dose range for 2,3-NBMD-2C-C would also be somewhat higher I guess, making it easier to dose - measuring 500 or 300 mcg is painful. And NBOMe-2C-C is also not among the worst, so I'd expect NBMD-2C-C to be nearly the same thing, yet easier to handle.

 

[Erny]

I'd just rather the people not get bullied by people with a greater understanding of something into not asking questions because they are intimidated, and as a result move forward in his/her experiment with false assumptions or incorrect knowledge. I'm glad you are here with your knowledge, but please, don't create an atmosphere where people will not ask questions. When people's lives are on the line, and they most certainly can be with some of these new chems active in the microgram range, wouldn't you agree it is in the interest of all to remove the attitude and allow for even the most naive of questions to be asked to help prevent any harm to the individual, and also to the community? I'd guess you'd agree to this since you've taken the time to share the information in the first place, and have even gone out of your way to post the link from ADD to PD. I'm just not understanding why the condescending attitude is necessary.

It's all fine, but I fear you may have to do so in my absence, I may just vanish from here for something like half a year, as it happened before. And don't feel like willing to spend my lifetime answering such questions in general. I just hope bluelight community will be able to make good use of information it has already.

 

[atara]

Eye-dropped 250 micrograms under my tongue as a 1 mg/ml solution about five minutes ago. I'm still wondering if I did it right, 'cuz I always think I'm screwing up sublingual dosing. First thoughts: this stuff is sour, though maybe that's just the residual toothpaste flavor.

It doesn't taste DOx bitter, though.

EDIT: Some teeth-clench feeling that is almost surely non-placebo.

 

[Lawrence]

Eye-dropped 250 micrograms under my tongue as a 1 mg/ml solution about five minutes ago. I'm still wondering if I did it right, 'cuz I always think I'm screwing up sublingual dosing. First thoughts: this stuff is sour, though maybe that's just the residual toothpaste flavor.

It doesn't taste DOx bitter, though.

And after what happens ? What kind of solution did you use ?

 

[atara]

And after what happens ? What kind of solution did you use ?

I am, or should be, coming up, as we speak. I think I did it right. Um. Sublingual dosing liquids is confusing, I think I only managed to hold it there for like three minutes whereas LSD I usually go for ten.

EDIT: If this is the effect, it's the most sedating psychedelic I've ever had. Though, that list only counts a few, and I've tended towards things like 2C-I in the past.

 

[psykap]

Maybe you try higher dose? Did you had more effects?