Saucy
Bluelighter
- Joined
- Aug 20, 2009
- Messages
- 324
Is this an assumption or an empirical observation?
Are you quoting a study? I'd like more details on this please.
One of my absolute favourite combos is K+MDMA (or MDA) and it would be fun to know if my brain will melt through my ears at the 15 year mark.
There haven't been any studies specific to the combination that I know of, but there are a few factors to consider when considering the safety profile of concurrent use of these drugs.
Ketamine and MDMA both increase blood pressure, and because their mechanisms for inducing this are different, it is possible that the increase will be greater than the sum of its parts so to speak. For a healthy individual this shouldn't be a serious issue though.
MDMA causes a substantial increase in serotonin levels, and ketamine inhibits serotonin reuptake, so there is definitely a theoretical mechanism for serotonergic toxicity here. The fact that MDMA is known to cause serotonin syndrome in combination with other NMDA antagonists and Sigma agonists (such as dextromethrophan) would seem to reinforce this theory, although this definitely is more relevant pertaining to the pharmocology of morphinans than arylcyclohexylamines like Ketamine.
Ketamine on its own is known to lower the seisure threshold, which undoubtedly could be exacerbated by the hypertensive and hyperthermic increases associated with MDMA use.
As I said earlier though, many have used this combination without issues, so its probably relatively safe, and there is no documented contraindication between the two although this has not been researched much if at all. Perhaps one more thing to consider is that long term use of both of these drugs on their own has been associated with cognitive impairment and/or memory problems, so I would imagine that long term concurrent use of MDMA and Ketamine is probably something to be avoided.
Even having said all this, though, I would like to note that I would actually consider using the combination myself, although I would look at it as a rare treat rather than something that I would want to do often.