Chris Timothy
Bluelighter
Upfront clarification: this is not about the use of actual Antabuse/Disulfram on dissociatives. Alcohol detox blocking wouldn't work, for obvious reasons. And I'm not even talking about making dissociative users similarly ill. I'm just borrowing the name to highlight the thread's purpose in a self-explanatory fashion: is there any substance that would help fight abuse of dissociatives? Is there some sort of guardian angle imaginable?
In my crusade against tinnitus I happened to have stumbled upon something that turns out to operate on dissociatives as Naltrexone does on alcohol. As some of you might know, this opioid blocker takes away the joy of drinking for some reason. Well, it turns out that preloading with the herb "Angelica Archangelica" nullifies the trip! To be precise, there's no complete cancellation of effect, but a lack of lift-off, it leaves an utter absence of trippiness. Only effect left is some peripheral stimulation, which puts one in anticipation of mind expansion that just doesn't happen, and is in that sense unpleasant. It makes dosing feel pointless, just like drinking on Naltrexone is supposed to be. The herb throws a wrench somewhere in the NMDA-antagonism cascade.
I'm not entirely sure what this mechanism of action is. Possibly it's the various ion-channel-blocking effects I investigated it for. But for instance lidocaine still allows dissociation when combined, so surely it's not natrium channel blockage. Calcium channel blockage would make more sense: ketamine's action works via L-type calcium channels to synthesize BDNF. I'm specifying channel type, as clearly not all types of blockage work. For instance, phenibut combines fine with dissociatives, doesn't it? So I'm sure it's not the specific blocking of gabapentanoids that are pertinent.
If this L-type calcium channel hypothesis is correct, then logically drugs based on dipydropyridine (DHP) would also work. It would be interesting to know whether this is more effective than the herb or whether its chemicals work synergistically, but the trouble is is that DHP drugs are heart medication. So we might wanna stick to the readily available Angelica Archangelica, which doesn't mess with the heart at all in my experience.
Technicalities aside, how to utilize this knowledge? First the disclaimer: if you find yourself addicted to dissociatives, then this will not cure you. It will not magically reinstate your psychological faculty of choice, nor stabilize any wrecked mood. But, just as how Naltrexone is commonly used with alcoholics, it will help relapses. Once you've provided yourself with deeper stability, then Angelica will guard against its erosion. At first it will happen a couple times that you dose anyway even though the tea of the roots has been consumed. But you'll feel silly. And after enough trial and inevitable error the impossibility of getting high gets associated with the tea, ingrained on a carnal level. And the intrusive, compulsive thoughts about dosing will vanish.
Can't you just not drink the tea and then trip, you ask? Why yes. You are certainly able to plan to circumvent it. But you can't impulsively do so. If you have a habit of drinking the tea every morning, then you have effectively replaced one habit with another, which is much easier than constantly putting up mental resistence against one habit. Another cup in the evening is also a good idea, if evenings pose a risk. That way your entire waking hours are insured against, well, tripping hazard. Easiest is probably to have it with meals. Then it's not as much of a separate thing, but an extension of an already existing, daily ritual, and gets done without putting any thought into it whatsoever.
Wanna perform a rationally planned trip? Cool, then it starts with the conscious effort not to habitually suck root juice. Notice that difference: it starts with consciously breaking a habit instead of mindlessly indulging in one. Moreover, it gets easier to stick to a planned amount of doses: simply drink a cup after the last dose, turning off the BDNF tap at the ion channel level, and the cessation is irreversibly marked. The K demon is rendered powerless, it won't be able to change your mind sitting on your shoulder bewhispering your ear thanks to this guardian archangel on the other side, the angel of the highest rank.
Angelica Archangelica is a European plant. I don't know how easy it is to import for you ammosexuals. It has US family too, but I don't know whether every Angelica species shares the relevant mechanism. So lots of opportunity for experiment, research and feedback in the form of your experiences, if in any way intrigued. Do feel free to use this thread.
In my crusade against tinnitus I happened to have stumbled upon something that turns out to operate on dissociatives as Naltrexone does on alcohol. As some of you might know, this opioid blocker takes away the joy of drinking for some reason. Well, it turns out that preloading with the herb "Angelica Archangelica" nullifies the trip! To be precise, there's no complete cancellation of effect, but a lack of lift-off, it leaves an utter absence of trippiness. Only effect left is some peripheral stimulation, which puts one in anticipation of mind expansion that just doesn't happen, and is in that sense unpleasant. It makes dosing feel pointless, just like drinking on Naltrexone is supposed to be. The herb throws a wrench somewhere in the NMDA-antagonism cascade.
I'm not entirely sure what this mechanism of action is. Possibly it's the various ion-channel-blocking effects I investigated it for. But for instance lidocaine still allows dissociation when combined, so surely it's not natrium channel blockage. Calcium channel blockage would make more sense: ketamine's action works via L-type calcium channels to synthesize BDNF. I'm specifying channel type, as clearly not all types of blockage work. For instance, phenibut combines fine with dissociatives, doesn't it? So I'm sure it's not the specific blocking of gabapentanoids that are pertinent.
If this L-type calcium channel hypothesis is correct, then logically drugs based on dipydropyridine (DHP) would also work. It would be interesting to know whether this is more effective than the herb or whether its chemicals work synergistically, but the trouble is is that DHP drugs are heart medication. So we might wanna stick to the readily available Angelica Archangelica, which doesn't mess with the heart at all in my experience.
Technicalities aside, how to utilize this knowledge? First the disclaimer: if you find yourself addicted to dissociatives, then this will not cure you. It will not magically reinstate your psychological faculty of choice, nor stabilize any wrecked mood. But, just as how Naltrexone is commonly used with alcoholics, it will help relapses. Once you've provided yourself with deeper stability, then Angelica will guard against its erosion. At first it will happen a couple times that you dose anyway even though the tea of the roots has been consumed. But you'll feel silly. And after enough trial and inevitable error the impossibility of getting high gets associated with the tea, ingrained on a carnal level. And the intrusive, compulsive thoughts about dosing will vanish.
Can't you just not drink the tea and then trip, you ask? Why yes. You are certainly able to plan to circumvent it. But you can't impulsively do so. If you have a habit of drinking the tea every morning, then you have effectively replaced one habit with another, which is much easier than constantly putting up mental resistence against one habit. Another cup in the evening is also a good idea, if evenings pose a risk. That way your entire waking hours are insured against, well, tripping hazard. Easiest is probably to have it with meals. Then it's not as much of a separate thing, but an extension of an already existing, daily ritual, and gets done without putting any thought into it whatsoever.
Wanna perform a rationally planned trip? Cool, then it starts with the conscious effort not to habitually suck root juice. Notice that difference: it starts with consciously breaking a habit instead of mindlessly indulging in one. Moreover, it gets easier to stick to a planned amount of doses: simply drink a cup after the last dose, turning off the BDNF tap at the ion channel level, and the cessation is irreversibly marked. The K demon is rendered powerless, it won't be able to change your mind sitting on your shoulder bewhispering your ear thanks to this guardian archangel on the other side, the angel of the highest rank.
Angelica Archangelica is a European plant. I don't know how easy it is to import for you ammosexuals. It has US family too, but I don't know whether every Angelica species shares the relevant mechanism. So lots of opportunity for experiment, research and feedback in the form of your experiences, if in any way intrigued. Do feel free to use this thread.
