THC withdrawal (anhedonia/anxiety) occurs via dopamine and opioid mechanisms

[Jabberwocky]

Daily Δ9-Tetrahydrocannabinol and Withdrawal Increase Dopamine D1-D2 Receptor Heteromer to Mediate Anhedonia- and Anxiogenic-like Behavior Through a Dynorphin and Kappa Opioid Receptor Mechanism

Frequent cannabis use is associated with a higher risk of developing cannabis use disorder and other adverse consequences. However, rodent models stud…

www.sciencedirect.com

Chronic THC increases NAc dopamine D1-D2 receptor heteromer expression and function, which results in increased dynorphin expression and KOR activation. These changes plausibly reduce dopamine release, to trigger anxiogenic- and anhedonic-like behaviors after daily THC administration that persist for at least 7 days after drug cessation.

 

[G_Chem]

No more “cannabis doesn’t have withdrawals” bullshit! I personally get them really bad.. When I went to rehab the detox couldn’t fathom why I was still sick after 24hrs, as if one should magically be better.

-GC

 

[Jabberwocky]

No more “cannabis doesn’t have withdrawals” bullshit! I personally get them really bad.. When I went to rehab the detox couldn’t fathom why I was still sick after 24hrs, as if one should magically be better.

-GC

I used to get them badly as well, but I was always under the impression it was mostly psychological because I could always overcome the symptoms with mental fortitude and a positive attitude, unlike other dependencies. Interesting to finally see some science on it.

The reduced appetite always sucked, though, and couldn't get passed that.

 

[PtahTek]

Never really experienced wd from MJ until I started fuckin with distillation.
Done with that.
Flower is still OK in my book but cant afford it. Meh; Dont miss it anyway....