Opioids Tapentadol questions (IV, dosage ceiling etc)

[Toz]

So, tomorrow it's been another week since I used opioids so I'd figure it's worth a shot again. I may have a chance to buy some tapentadol pills, seeing as my friend who is now scripted fentanyl no longer needs them and I wonder if they are worth getting? Do they have any kind of "ceiling dose" like tramadol? I used to love tramadol some years ago, but I quit taking them after my tolerance went through the roof and I had a seizure after taking about ~2000mg. So I wonder if there is any chance of these unpleasant serotonergic effects from tapentadol too? And at what dosage, if so?

To have a good time, I need about 150mg morphine hcl IV. Will tapentadol be possible to take in a dose that would yield similiar effects without any problematic side effects? Also how much tapentadol would = 150mg of morphine hcl?

I would also like to ask if anyone here has tried to IV tapentadol, if so, what was it like? I did IV high doses of tramadol 2 times but found the "rush" to be really unpleasant, so if it's anything like that, I'll pass.

Answers are much appreciated

 

[Phat5o]

i have never IV'ed anything. but i must say that tapentadol is one of my favorite opioids ever and my DOC as of right now. it's NOTHING like tramadol at all, i barely get anything out of tramadol, tapentadol is a lot more euphoric and to me seems very similar to oxy.. like a speedy high at first then kind of a noddy high for the next hour or two. i don't have that high of a tolerance so i usually take 150 - 200 mg. that to me is equal to about 20 - 30mg of oxy. i don't think tapentadol has a ceiling dose either.

 

[tricomb]

I would strongly recommend against shooting up an SNRI. Tapentadol is so closely related to tramadol, regardless of if "it doesn't feel like tramadol"

Also, from what I've heard, these are some of the most damaging pills that one might inject, right up there with OxyContin.

 

[Toz]

I would strongly recommend against shooting up an SNRI. Tapentadol is so closely related to tramadol, regardless of if "it doesn't feel like tramadol"

Also, from what I've heard, these are some of the most damaging pills that one might inject, right up there with OxyContin.

Tapentadol is not an SNRI -> serotonin / norepinephrine reuptake inhibitor, that's what it means, right? It's just a norepinephrine reuptake inhibitor. Not really sure what difference it makes though. My pills are Palexia 50mg (extended release).

I found an equivalance table that compared oral dosages as being Morphine 200mg<=> Tapentadol 500mg<=> Oxicodone 100mg. So I would need at least 10 pills if taken orally, really? Sigh. If anyone could find out the rectal bioavailabilty of tapentadol it would be much appreciated.

 

[Hiltoniano]

Taking 500+ mg of tapentadol to match your IV morphine dose sounds like a recipe for disaster, if not then seizures

 

[Toz]

500mg of tapentadol was ingested orally as crushed pills/powder, while the opioid effect was more pronounced than tramadol, it was shorter lasting than morphine and didn't produce as much euphoria. I also experienced really bad short-term memory loss, I would try to say something to my friend but would lose myself mid-sentance and forget what I was talking about completely. I also felt weird and shaky. I do not think I will repeat this experience, maybe with some clonazepam a higher dose would be tolerable.

 

[ErgicMergic]

Tricomb, tapentadol is more like O-Desmethyltramadol, but with a half life of 4 hrs instead of ~9h from O-Des.

The molecular structures look almost identical, since it was formulated to give consistent results regardless of how many copies of the CYP2D6 enzymes you have in your liver, unlike tramadol where the difference bettween a 2D6 deficiency and means drastic opioid activity from the converted O-Desmethyltramadol metabolite, since tram needs the 2D6 enzymes for O-Desmethylation.


I would stay away from high doses of nucynta, the delirium I get (auditory hallucinations during nodding, much more realistic than other opioids, and really weird CEVs) from taking more than 300-400mg+ over the course of ~12 hours is ridiculously realistic and very unpleasant. My brother said he saw peripheral vision hallucinations on 200mg IR, and my mom also had my same weird experiences which turned her off opioids for good.

 

[Toz]

Tricomb, tapentadol is more like O-Desmethyltramadol, but with a half life of 4 hrs instead of ~9h from O-Des.

The molecular structures look almost identical, and it was designed to give consistent results regardless of how many copies of the CYP2D6 enzymes you have in your liver, unlike tramadol where the difference bettween a 2D6 deficiency and means drastic opioid activity from the converted O-Desmethyltramadol metabolite, since tram needs the 2D6 enzymes for O-Desmethylation.


I would stay away from high doses of nucynta, the delirium I get (auditory hallucinations during nodding, much more realistic than other opioids, and really weird CEVs) from taking more than 300-400mg+ is ridiculously realistic and very unpleasant. My brother said he saw peripheral vision hallucinations on 200mg IR, and my mom also had my same weird experiences which turned her off opioids for good.

I also experienced some of these effects, although they were not that prounounced and I thought it was mainly from the weed I was smoking/being tired in combination with the tapentadol. It seems like this substance doesn't posses much recreational value if you have a tolerance to begin with.