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Taking Prozac after a roll to reduce neurotoxic effects.

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Bluelighter
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If one's guinea pig has it available, perhaps think about something like Prozac (fluoxetine), or Celexa (citalopram), both SSRI's (selective-serotonin reuptake inhibitor). SSRI's have a high (ie higher than dopamine) affinity (attraction) for serotonin transporters. Since the theory behind MDMA neurotoxicity concerns the reuptake of dopamine after serotonin depletion, perhaps fluoxetine can prevent this reuptake, as when it binds to serotonin transporters it sticks and it is difficult for things to get back into the cell (hence why it is used to treat depression- it inhibits the reuptake of serotonin [which regulates mood], increasing the serotonin concentration in the synapse).

Read more: http://www.drugs-forum.com/forum/showthread.php?t=108415#ixzz1oKWyciKA
Click to expand...

anyone try this? i was prescribed prozac a few years back when my parents thought counseling would help 8) and i never took it, any thoughts?
 
Realistically you are better off just getting some sleep after taking mdma. Taking more chemicals isnt always a good idea.
However, i did see a study that if you take SSRI after mdma it prevents some of the neurotoxicity, wish i saved that page so that i could show you.

Made me think about it before i threw my citalopram (SSRI) in the bin,
 
Darksidesam said:
Realistically you are better off just getting some sleep after taking mdma. Taking more chemicals isnt always a good idea.
However, i did see a study that if you take SSRI after mdma it prevents some of the neurotoxicity, wish i saved that page so that i could show you.
Click to expand...

Quote from Erowid - http://www.erowid.org/chemicals/mdma/mdma_neurotoxicity1.shtml

The time course of damaging events in rats can be seen by administering SSRIs, such as fluoxetine and citalopram, after MDMA. Pretreatment with fluoxetine (Prozac) or citalopram (Celexa) has been shown to block the neurotoxicity of MDMA (Battaglia, 1988; Schmidt 1987; 1990; Shankaran, 1999a), probably by blocking interactions of MDMA with SERT. More interestingly, fluoxetine remains almost fully protective if given 3 or 4 hours after MDMA. By 4 hours, most of the MDMA-induced release of 5-HT and DA has already occurred (Gough, 1991; Hiramatsu, 1990) and increases in extracellular free radicals (Colado, 1997b; Shankaran, 1999a) and lipid peroxidation (the alteration of fat molecules by free radicals) (Colado, 1997a) can be measured. Nevertheless, the administration of fluoxetine at this point decreases subsequent extracellular oxidative stress (Shankaran, 1999a) and long-term 5-HT depletions (Schmidt, 1987; Shankaran, 1999a). Fluoxetine will still be partially protective if given 6 hours after MDMA but has no protective effect 12 hours after administration (Schmidt, 1987). This shows that neurotoxic MDMA regimens initiate a series of events that become increasingly damaging between 3 and 12 hours after drug administration in rats.
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I don't believe MDMA to be that neurotoxic, not neurotoxic enough to take an SSRI anyway.

Maybe if you use MDMA every single weekend I would look at taking an SSRI after stopping mdma completely.

I've just never had good opinions on SSRI's. BUT this is my own opinion, everyone else will have theirs.
 
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Some of the worst ever drug experiences/ anxiety / strangeness i ever experienced was from taking Citalopram (SSRI)
 
MDMA is a neurotoxin by nature.
Taking anything that competes with the dopamine uptake into serotonin transporters and receptors will substantially reduce neurotoxicity.

The key is to take it about three hours after your MDMA dose.
This means that neurotoxicity begins occurring right as you start coming down - as your serotonin levels begin to fall.
There is a window of opportunity for affording this neuroprotection, and it requires essentially shutting off the euphoria that still remains after the peak.
I've always thought this was an incredible research finding that would allow for the 'safe' use of MDMA.

But scientists are wary of parading this information as true protection.
And users seldom have the discipline to shut off the experience they are having.
No....they are much more likely to redose more neurotoxin!
 
The onset of some SSRIs takes weeks, but in a state of serotonin depletion they can have very rapid effects.
This is seen in women with PMDD, or premenstrual dsyhporic disorder.

Just as with the intestines, the smooth muscle surrounding the uterus requires serotonin to contract - sometimes enough to substantially reduce higher brain serotonin and cause a dopamine imbalance.
This is a type of temporary psychosis.

Tiny doses of SSRIs work in a matter of hours for these women!
 
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