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Taking all the drugs of a class at once?

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Treefa

Treefa

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Krombopulous Michael
Don't worry i don't have the resources to actually try this, but i have a question;

If you take all the drugs in a class(for instance opiates, if you took codeine, morphine, hydrocodone, dilaudid, oxycodone, etc...) if you took just a little bit of all of them, would it fit in your brain like the master puzzle peice resulting in ultimate analgesia(for opiates, but for benzos could be relief of all anxiety/sedation, or antihistimanes could be a really dried up upper resprotory system?)?

Or would it just over saturate your receptors causing overdose, or bad effects?

Thanks, treefa.
 
Just general opioid effects and/or overdose. Opioid just bind to opioid peptide receptors, in the context of recreation and analgesia, the mu receptor is the main one. The difference between opiods is their affinity and selectivity to that receptor. Too much activation on said receptor, and you die from respiratory depression. Their is no intrinsic synergy from mixing
 
Generally the more drugs you add to a cocktail the more possibility for side-effects and unwanted interactions (potentiation, cancellation) you have.

Multidrug cocktails where you are targeting just one receptor are a waste of your time. The opioid with the highest affinity will produce an effect at mu-opioid, but the side effects like itching and drowsiness will probably be additive. End result is you'll have the same effects as e.g. dilaudid but it will be much 'dirtier'

not to mention it would be nigh impossible to dose safely, as you'd have no idea how the drugs interacted
 
i understand what youre getting at, i like to mix psychedelics to add different "layers" to my trips, and different analogues push the buttons slightly different than their cousins. i wouldnt try it with opiates unless you had some serious lab equipment and a death wish. like seiko said, the highest affinity mu-agonist would be the primary pleasure effects, the other opioids would hit the peripheral receptors like kappa (the target of salvinorin A, and the same receptor that causes hallucinations with morphine)
 
with psychedelics its worth it i.e. 4aco dmt and 2ci which are much better in combo than individually as there is the energy of 2ci and the depth of 4aco. with stims it was kinda pointless same with opiates. tramadol and morphine is a great combo but codeine and morphine was just nastier than morphine (in poppy tea) on its own (i am aware there is codeine in poppy tea but not 60mg in one head) more nausea more itching.
 
Mixing hallucinogens may be much more fruitful than mixing opioids/stimulants, as there are quite a few serotonin receptors that "typical" hallucinogens interact with, so you have more of a synergistic "rainbow effect" where two drugs produce stronger f/x than either alone.

That is, most opioids only produce effects through mu/delta opioid, but e.g. DMT hits at least 5-HT2abc, 5-HT1abd, 5HT3, 5HT7, etc.
 
im pretty sure it would fuck you up. when i lost my job back in december( had it for 6 years, cooking job. i now work at a golf course)the weekend where i blacked out and nodded out following by me changing around my time card which i dont remember and have never ever done, well i took about 8 mg of dilaudid, 10 mgs of kpins, xanax, couple valium, op 80, couple perks and vics, 3 or 4 30s, 1 stamp all in the course of a weekend. well i ended up doing a bunch of dumb shit and got fired. i had minimal tolerance to these drugs and no benzo tolerance at all. either way i wouldnt recommend it at all. i did feel excellent tho but its dangerous and i wouldnt advise it.
 
smokemctoke420 said:
im pretty sure it would fuck you up. when i lost my job back in december( had it for 6 years, cooking job. i now work at a golf course)the weekend where i blacked out and nodded out following by me changing around my time card which i dont remember and have never ever done, well i took about 8 mg of dilaudid, 10 mgs of kpins, xanax, couple valium, op 80, couple perks and vics, 3 or 4 30s, 1 stamp all in the course of a weekend. well i ended up doing a bunch of dumb shit and got fired. i had minimal tolerance to these drugs and no benzo tolerance at all. either way i wouldnt recommend it at all. i did feel excellent tho but its dangerous and i wouldnt advise it.
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im suprised you didnt wake up in the hospital for that binge, or worse
 
Generally one or two drugs will override the effects of the others in the same class. That would make sense to me and from my limited experience of mixing within the same class. I would agree that psychedlics you can basically combine as many as you like and they will add different aspects to your trip but the more you involve the more confident you need to be to avoid being overwhelmed and it is would probably get to the point where more trippy elements were just not needed - eg mescaline is such a long lasting, well rounded experience the need to add other drugs to it let alone other psychedlics is minimal. Similarly from the opiates I have taken, opium was so strong I'm not sure I would want to take many/any opiates alongside it.

Plus as has already been already mentioned. Drugs in the same class potentiate each other. Taking every opiate at once would leave you dead. Taking every stimulant at once would leave you dead.
 
For opiates, if your doses are all nominal to compensate or the fact that you are taking many at once, then the main thing you'd have to worry about is cross-interaction. Other than that, it would just be opiates binding to opiate receptors as usual.

Since most pharmaceuticals have side effects, you would just be increasing the number and range of side effects you would experience vs. if you just took a single drug from that class. Not worth it, IMO. The hangover would feel awful.
 
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