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  • N&PD Moderators: Skorpio | someguyontheinternet

Synergistic Effects of Lamotrigine and Vyvanse?

I think OP is perhaps thinking too deeply about this, albeit interesting, idea.

It is common knowledge in Psychology that the most rewarding activities are those which are unpredictable. You can see a good example of this with OPs "Steve" character - as soon as he moves next door, the rewards become predictable and the magic is lost.

Lamotrigine, and basically all other mood stabilizers (valproates, (ox)carbazepines, etc) will prevent "runaway stimulation" - this is why they are effective prophylaxis for epilepsy and bipolar disorders (an interesting, and fairly accurate, way to think of bipolar disorder is "emotional epilepsy").

Amphetamines are not for everyone. OP may have some sort of underlying cyclothymic defect. Do not generalize your own experiences onto the rest of the population at large. In psychology. We would say your hypothesis has poor construct validity, and murky external validity.

OP, you may want to try Focalin (dexmethylphenidate). IME, it is more efficacious in the cyclothymic populous.
 
Ho-Chi-Minh said:
So do you have a source then?

Lamictal would have to infiltrate the presynaptic neuron in order to affect sodium ion channels pesynaptically, which to my knowledge no drug does or can do. I'm sorry but I don't see how that is possible. Are you talking about voltage, or ligand, gated ion channels?

I would think that it would be more of a common side effect if that were the case...I mean it makes sense that blocking calcium anion influx would occur on GABAergic as well as glutamate predominate neurons, but the latter much more so than the former.

I mean, any drug that, in one way or another, overall reduces GABAergic activity, doesn't sound like an anticonvulsant.

Awesome. We're good :).
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No it wouldn't. Presynaptic sodium channels exist on the presynaptic membrane, just like they do on postsynaptic membrane. And gabapentin and pregabalin can gain access into neuron via the l amino acid transporter; this how they induce non vesicular release of GABA. Amphetamines also enter neurons.
 
^I may be incorrect, but to the best of my recollections, amphetamines are transported through intracellular membranes specifically by binding to the VMAT, something which the vast majority of psychiatric drugs (including, say, lamotrigine) have a negligible affinity for.

I would be interested to see the proposed mechanism for lamotrigine being taken into the pre synaptic neuron
 
N0 W4RN1NG said:
^I may be incorrect, but to the best of my recollections, amphetamines are transported through intracellular membranes specifically by binding to the VMAT, something which the vast majority of psychiatric drugs (including, say, lamotrigine) have a negligible affinity for.

I would be interested to see the proposed mechanism for lamotrigine being taken into the pre synaptic neuron
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They are, and I never said it did.
 
theGirlWithBlueHair said:
All sodium channel blockers can cause a fatal rash. Barbiturates can too.
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Doubtful

theGirlWithBlueHair said:
No it wouldn't. Presynaptic sodium channels exist on the presynaptic membrane, just like they do on postsynaptic membrane. And gabapentin and pregabalin can gain access into neuron via the l amino acid transporter; this how they induce non vesicular release of GABA. Amphetamines also enter neurons.
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Not on the terminal. It's like saying that channel proteins exist on the presynpatic neuron...yeah, but way the hell on the other side.

Amphetamine is only one chemical that causes reverse transport. Regardless, the two work very differently.
 
I didn't say they worked the same...

I was giving examples.

Channel proteins exist on the plasma membrane. Straight from Neuroscience book, fourth edition, dale purves, george j augustin, david gitzpatrick, william c hall, anthony-samuel laMantia, james o.mcNamara, leaonard,= e. white
2008
 
We might be careful to differentiate between pre synaptic (on the terminal) and extrasynaptic
 
I didn't say they worked the same...

I was giving examples.
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As in, they don't work the same at all, to the extent that putting them in the same general category reflects significant naivete. Why don't you just group acetylchollinesterase and MAO in the same category because they both break down neurotransmitters?

Channel proteins exist on the plasma membrane. Straight from Neuroscience book, fourth edition, dale purves, george j augustin, david gitzpatrick, william c hall, anthony-samuel laMantia, james o.mcNamara, leaonard,= e. white
2008
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...where else would they exist? Lol

start getting your information from books people, not the internet
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When it comes to neuroscience, eight years old is usually outdated. And if you know what to look for in a good source, you can find lots of quality studies on the internet.
 
No just that they both enter the neuron> I wasn't putting them into the same same catergory. That isn't naivete. They were just fucking examples. You are naive for not understanding this simple concept.

You didn't seem to understand stand this. LOLOLOL
 
No just that they both enter the neuron> I wasn't putting them into the same same catergory. That isn't naivete. They were just fucking examples. You are naive for not understanding this simple concept.

You didn't seem to understand stand this. LOLOLOL

Outdated. The information is still correct... haha
 
Ho-Chi-Minh said:
As in, they don't work the same at all, to the extent that putting them in the same general category reflects significant naivete. Why don't you just group acetylchollinesterase and MAO in the same category because they both break down neurotransmitters?



...where else would they exist? Lol



When it comes to neuroscience, eight years old is usually outdated. And if you know what to look for in a good source, you can find lots of quality studies on the internet.
Click to expand...

Why do you always have to mock me...?
 
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