neu_nobody
Bluelighter
- Joined
- Mar 28, 2024
- Messages
- 48
How to cope? Mainly increased heart rate, sweating. I know clonidine helps, but I can't get it. I have beta-blockers, are they okay to use? Maybe something OTC?
I just got memantine to reset my NMDA receptors (reverse ketamine tolerance) but I’m seeing it could help with opiate withdrawal and tolerance? Could somebody give me some info or point me in a direction?Can you get pregabalin/gabapentin, or a dissociative (the longer acting the better, memantine works well). Or a benzo of course?
But yeah a beta blocker will lower the heart rate at least.
I used memantine megadoses to get off morphine (480mg/d, before up to 600) and it worked better than I expected. There was some residual anxiety and lethargy but not too much, I'd say I could have gone to work if I had had to. My gf didn't realize much and we are living together. I used up to more than 100mg of memantine per dose but I had disso permatolerance. In PubMed papers they used 60mg as a start. Seems that memantine is an exceptionally safe substance. read about doses as high as 300mg but this will have you holing for days. It's also the cleanest dissociative I know of so far. I think NMDA antagonists are very underrated/-used medicinally.I’m seeing it could help with opiate withdrawal and tolerance? Could somebody give me some info or point me in a direction?
Also for somebody using it to lower kratom tolorence - what dose would be effective and frequency? I’m wondering if I make it a daily think or just one large dose?I used memantine megadoses to get off morphine (480mg/d, before up to 600) and it worked better than I expected. There was some residual anxiety and lethargy but not too much, I'd say I could have gone to work if I had had to. My gf didn't realize much and we are living together. I used up to more than 100mg of memantine per dose but I had disso permatolerance. In PubMed papers they used 60mg as a start. Seems that memantine is an exceptionally safe substance. read about doses as high as 300mg but this will have you holing for days. It's also the cleanest dissociative I know of so far. I think NMDA antagonists are very underrated/-used medicinally.
But memantine shares cross-tolerance with other NMDA antagonists and won't reverse tolerance to ketamine. The only thing I know to lower disso tolerance to some extent is sobriety. I've been sober for 3 years now and recently found a leftover bottle of DXM and of course had to do it. When back before my break I could down 600mg of DXM with no dissociation so did now 150mg work well. So tolerance does go down again but it takes ages and I guess not down to zero.
I heard about sarcosine possibly helping but its mechanism scares me (it's a NMDA partial agonist) because dissos are anxiolytic for me and I have an anxiety disorder so I guess sarcosine would give me anxiety. And NAC but I tried this one and it did nothing.
Did you take large memantine doses to disassociate during a cold turkey or did you use it a different way?I used memantine megadoses to get off morphine (480mg/d, before up to 600) and it worked better than I expected. There was some residual anxiety and lethargy but not too much, I'd say I could have gone to work if I had had to. My gf didn't realize much and we are living together. I used up to more than 100mg of memantine per dose but I had disso permatolerance. In PubMed papers they used 60mg as a start. Seems that memantine is an exceptionally safe substance. read about doses as high as 300mg but this will have you holing for days. It's also the cleanest dissociative I know of so far. I think NMDA antagonists are very underrated/-used medicinally.
But memantine shares cross-tolerance with other NMDA antagonists and won't reverse tolerance to ketamine. The only thing I know to lower disso tolerance to some extent is sobriety. I've been sober for 3 years now and recently found a leftover bottle of DXM and of course had to do it. When back before my break I could down 600mg of DXM with no dissociation so did now 150mg work well. So tolerance does go down again but it takes ages and I guess not down to zero.
I heard about sarcosine possibly helping but its mechanism scares me (it's a NMDA partial agonist) because dissos are anxiolytic for me and I have an anxiety disorder so I guess sarcosine would give me anxiety. And NAC but I tried this one and it did nothing.
Before @dopamimetic answers,Did you take large memantine doses to disassociate during a cold turkey or did you use it a different way?