adder
Bluelighter
- Joined
- Mar 28, 2006
- Messages
- 2,851
Thanks for the replies!
One guy I met at the ward reported that he got diarrhea when he swallowed saliva with not totally dissolved pill. I think a lot of people are unaware that the effects on opioid receptors of naloxone are totally blocked by buprenorphine. It's true that naloxone gets faster to the receptors in the brain but it's still a difference of seconds, I guess, and buprenorphine doesn't need to occupy a lot of receptors to promote its mu-activating properties in contrast to some other opioids. Also, when doses are repeated, buprenorphine is still already occupying receptors so naloxone doesn't stand a chance to do its job. Addicts generally don't know much about the way opioids work, another trend is if they have some information, it's often wrong or mostly wrong. It stroke me at first but then I realized my knowledge on opioid systems comes fully from general interest in neuropharmacology and chemistry. Being an addict doesn't mean being interested in pharmadynamics and pharmacokinetics of taken drugs and/or chemistry. And being a chemist doesn't mean ending up as an addict because of some knowledge in the fields of science crossing with chemistry - I was often accused by my mum that my interest in chemistry led me to addiction which is totally untrue.
I noticed the same thing concerning nodding on Suboxone. When I took clonazepam in the morning and Suboxone in the morning, this would happen. Also, I must admit that I used estazolam twice being already on Suboxone, and while I feel virtually no effects from a higher dose of clonazepam, estazolam and some other benzodiazepines with faster onset and a bit different pharmacodynamic profile will have an effect on me (e.g. I can feel the moment estazolam reaches enough levels to produce this strong but short-living anxiolytic effect, then it's just sedation, it used to be different but it's a proof for me that "tolerances" to different BZD receptor subunits build independently). But when I take clonazepam at ~10-11 PM and Suboxone in the morning the day after, there is no problem at all with nodding and buprenorphine's motivating and stimulating effects. And to be honest I need this substitution more because of refractory depression than because I keep getting back on opioids seeking euphoria, I took codeine to stop sweating. Maybe it sounds unbelievable but I've always been oversensitive about sweating because I had problems with it not only because of withdrawals but also due to anxiety. It was 2 months after I had stopped methadone so such terrible sweating became unbearable for me.
I guess my present tolerance plays a role here too. I didn't take opioids with "morphine core" in their structure in binges for a very long time before I got into codeine recently but it's much weaker. Other than that I injected morphine a few times dose after dose in August but it was just 200mg in total. Methadone was the main opioid I took on a daily basis for ~3 years (I round it as I don't remember the exact date I switched from pure buprenorphine hydrochloride, no naloxone, it was in a powder form). When I broke and started curing myself with codeine, my doctor first wanted to slowly taper me down with codeine but there is no codeine-only medication in Poland, so he placed me on tramadol. Again, tramadol is fully synthetic just as methadone. And tramadol was the drug with opioid properties I took before starting Suboxone. I guess that combined with my current health made 2mg enough. But since I left the hospital, I have been struggling with opposing thoughts. Maybe I could take 2mg every other day but today when I had to go to collect my Suboxone, I noticed my pupils had dilated, so maybe I should have stayed a few days longer and get used to 4mg dose. It's different functioning outside with all daily duties. I was to meet my doctor today but he didn't make it today to the give-away point (it's just ridiculous here in Poland how they make one person be the chief of the the maintenance programme, the senior registrar of the detox ward, and the specialist at the clinic; it's not that I'm justifying his absence today because I saw him drown in papers).
I need to meet him because I still don't have a programme participant card (thus I have no document to show in case my possession of Suboxone is questioned in some random situation) and I'm also in the process of tapering down clonazepam. The guys giving me away Suboxone today weren't really understanding that I'm a student and my lectures / laboratories start early in the morning and end not before 3 PM but on Fridays, thus I wanted to collect Suboxone on that day. Instead I got 5 pills which means I have to go to the university on Thursday without taking Suboxone, survive a 2-hour lecture on algorithms, and then ride to the give-away point... I know it's all in my head and buprenorphine has an effect on me for way more than 24 hours and I could easily dose it every 36 hours but today I sweated terribly on the way to the point so I know I will have to skip this algorithms lecture. It's anxiety coming from nowhere and I get Suboxone to treat it among other reasons, clonazepam reduction doesn't help but buprenorphine reduces all the anxiety luckily, I just have to cope with shaking hands right now.
I know the doctor is present at the clinic on Thursday. But as now I'm a participant of the programme and have clonazepam for a month, I don't really want to steal his time because I know how many patients sometimes show up. Anyhow, I guess I have no other option. I can't attend group meetings which helped me quite a bit because of lack of spare time. Now I don't want to skip lectures because of some mistrustful therapists at the point. I don't care, I can pee every week so they test me, I have nothing to hide. I know I'm new there and they don't know me yet but a bit more individual approach would be advisable for those guys. I'm aware a lot of methadone programme participants sell their syrup and often overstate their need for higher dose, but Suboxone is hardly demanded on the black market for God's sake... Besides generally much more % of people on Suboxone really see help in substitution and plan quitting it eventually than % of people on methadone.
- - - - - - - - - - - - -
As a side note:
Of course this is the situation in Poland. We've got only 18 programmes (+ 7 in prisons) with only 2 200 participants in 2011 (country's population is 38.5 million people, estimated number of opioid addicts is between 10 444 and 19 794, but a more realistic number would be ~40 000, it's simply hard to count addicted people). They start new programmes but they are all of some people's initiative, not because of National Health Fund interest in the situation of addicts in the country. And these new programmes show up rather to fill demand in the region so people just switch from an already existing programme to a new programme because they don't want to ride 400 km to collect their weekly ration any more, new programme doesn't mean 200 more places for addicts, they start with a low number of places, thus the queues keep long even for methadone.
Suboxone maintenance is still relatively new here. The programme in my city was one of the first programmes to get it and it's been available in my city since 2006. Out of these 18 programmes few offer Suboxone and there's a shortage of this drug generally (methadone is much cheaper for National Health Fund so they aren't really keen on making a much safer alternative available to all patients, they prefer to cuff people in liquid chains).
I hope it's not too much off-topic, I like knowing various facts about other countries in the world, so I sometimes post such stuff. If there's me interested in this, there must be more of such people.
Tommyboy said:Interestingly enough, I have noticed that when I take between 1-2mg of suboxone, I usually end up having to make a bowel movement within an hour of taking it. I don't take it regularly, and the max amount of consecutive days I will take it for is 4, but each of those days I will usually take 2 and then make a 2.
One guy I met at the ward reported that he got diarrhea when he swallowed saliva with not totally dissolved pill. I think a lot of people are unaware that the effects on opioid receptors of naloxone are totally blocked by buprenorphine. It's true that naloxone gets faster to the receptors in the brain but it's still a difference of seconds, I guess, and buprenorphine doesn't need to occupy a lot of receptors to promote its mu-activating properties in contrast to some other opioids. Also, when doses are repeated, buprenorphine is still already occupying receptors so naloxone doesn't stand a chance to do its job. Addicts generally don't know much about the way opioids work, another trend is if they have some information, it's often wrong or mostly wrong. It stroke me at first but then I realized my knowledge on opioid systems comes fully from general interest in neuropharmacology and chemistry. Being an addict doesn't mean being interested in pharmadynamics and pharmacokinetics of taken drugs and/or chemistry. And being a chemist doesn't mean ending up as an addict because of some knowledge in the fields of science crossing with chemistry - I was often accused by my mum that my interest in chemistry led me to addiction which is totally untrue.
I noticed the same thing concerning nodding on Suboxone. When I took clonazepam in the morning and Suboxone in the morning, this would happen. Also, I must admit that I used estazolam twice being already on Suboxone, and while I feel virtually no effects from a higher dose of clonazepam, estazolam and some other benzodiazepines with faster onset and a bit different pharmacodynamic profile will have an effect on me (e.g. I can feel the moment estazolam reaches enough levels to produce this strong but short-living anxiolytic effect, then it's just sedation, it used to be different but it's a proof for me that "tolerances" to different BZD receptor subunits build independently). But when I take clonazepam at ~10-11 PM and Suboxone in the morning the day after, there is no problem at all with nodding and buprenorphine's motivating and stimulating effects. And to be honest I need this substitution more because of refractory depression than because I keep getting back on opioids seeking euphoria, I took codeine to stop sweating. Maybe it sounds unbelievable but I've always been oversensitive about sweating because I had problems with it not only because of withdrawals but also due to anxiety. It was 2 months after I had stopped methadone so such terrible sweating became unbearable for me.
I guess my present tolerance plays a role here too. I didn't take opioids with "morphine core" in their structure in binges for a very long time before I got into codeine recently but it's much weaker. Other than that I injected morphine a few times dose after dose in August but it was just 200mg in total. Methadone was the main opioid I took on a daily basis for ~3 years (I round it as I don't remember the exact date I switched from pure buprenorphine hydrochloride, no naloxone, it was in a powder form). When I broke and started curing myself with codeine, my doctor first wanted to slowly taper me down with codeine but there is no codeine-only medication in Poland, so he placed me on tramadol. Again, tramadol is fully synthetic just as methadone. And tramadol was the drug with opioid properties I took before starting Suboxone. I guess that combined with my current health made 2mg enough. But since I left the hospital, I have been struggling with opposing thoughts. Maybe I could take 2mg every other day but today when I had to go to collect my Suboxone, I noticed my pupils had dilated, so maybe I should have stayed a few days longer and get used to 4mg dose. It's different functioning outside with all daily duties. I was to meet my doctor today but he didn't make it today to the give-away point (it's just ridiculous here in Poland how they make one person be the chief of the the maintenance programme, the senior registrar of the detox ward, and the specialist at the clinic; it's not that I'm justifying his absence today because I saw him drown in papers).
I need to meet him because I still don't have a programme participant card (thus I have no document to show in case my possession of Suboxone is questioned in some random situation) and I'm also in the process of tapering down clonazepam. The guys giving me away Suboxone today weren't really understanding that I'm a student and my lectures / laboratories start early in the morning and end not before 3 PM but on Fridays, thus I wanted to collect Suboxone on that day. Instead I got 5 pills which means I have to go to the university on Thursday without taking Suboxone, survive a 2-hour lecture on algorithms, and then ride to the give-away point... I know it's all in my head and buprenorphine has an effect on me for way more than 24 hours and I could easily dose it every 36 hours but today I sweated terribly on the way to the point so I know I will have to skip this algorithms lecture. It's anxiety coming from nowhere and I get Suboxone to treat it among other reasons, clonazepam reduction doesn't help but buprenorphine reduces all the anxiety luckily, I just have to cope with shaking hands right now.
I know the doctor is present at the clinic on Thursday. But as now I'm a participant of the programme and have clonazepam for a month, I don't really want to steal his time because I know how many patients sometimes show up. Anyhow, I guess I have no other option. I can't attend group meetings which helped me quite a bit because of lack of spare time. Now I don't want to skip lectures because of some mistrustful therapists at the point. I don't care, I can pee every week so they test me, I have nothing to hide. I know I'm new there and they don't know me yet but a bit more individual approach would be advisable for those guys. I'm aware a lot of methadone programme participants sell their syrup and often overstate their need for higher dose, but Suboxone is hardly demanded on the black market for God's sake... Besides generally much more % of people on Suboxone really see help in substitution and plan quitting it eventually than % of people on methadone.
- - - - - - - - - - - - -
As a side note:
Of course this is the situation in Poland. We've got only 18 programmes (+ 7 in prisons) with only 2 200 participants in 2011 (country's population is 38.5 million people, estimated number of opioid addicts is between 10 444 and 19 794, but a more realistic number would be ~40 000, it's simply hard to count addicted people). They start new programmes but they are all of some people's initiative, not because of National Health Fund interest in the situation of addicts in the country. And these new programmes show up rather to fill demand in the region so people just switch from an already existing programme to a new programme because they don't want to ride 400 km to collect their weekly ration any more, new programme doesn't mean 200 more places for addicts, they start with a low number of places, thus the queues keep long even for methadone.
Suboxone maintenance is still relatively new here. The programme in my city was one of the first programmes to get it and it's been available in my city since 2006. Out of these 18 programmes few offer Suboxone and there's a shortage of this drug generally (methadone is much cheaper for National Health Fund so they aren't really keen on making a much safer alternative available to all patients, they prefer to cuff people in liquid chains).
I hope it's not too much off-topic, I like knowing various facts about other countries in the world, so I sometimes post such stuff. If there's me interested in this, there must be more of such people.
