• MDMA &
    Empathogenic
    Drugs

    Welcome Guest!

Study Questions Toxic Effects of MDMA in Monkeys

BilZ0r said:
Badon LA, Hicks A, Lord K, Ogden BA, Meleg-Smith S, Varner KJ.
Changes in cardiovascular responsiveness and cardiotoxicity elicited during binge administration of Ecstasy.
J Pharmacol Exp Ther. 2002 Sep;302(3):898-907

It's not uncommon for serotonergics to be cardiotoxic in one form or another.. fenfluramine/phentermine....
That's interesting, but I'm still somewhat skeptical about it proving that MDMA is cardiotoxic at the average dosage used by humans. Again, if that were the case we would be seeing an increased incidence of heart related ailments in the MDMA user population. But we're not seeing that.

I would be just one example (so this doesn't prove much), but I'm 50 and I've taken MDMA many times over the past 15 years. My age would make me more susceptible to chemical assaults, but I haven't noticed anything occur.

At the same time, I would very much agree that someone who has an existing heart ailment should not use MDMA.

Thanks for the reference. :)
 
Hi Antonmesc,

It is sometimes possible to take a compound which is similar to another and derive effect information from one and apply it to the other. But this is seldom the case.

For example, MDMA is chemically similar to meth (which was the rational used by the DEA to place it under emergency scheduling). But meth can be very dangerous, and was the compound that produced Parkinsons disease in Ricaurte's test monkeys (this was where he "thought" he was using MDMA in the test series).

I know very little about MDA. But given its effects it appears to take a different pathway to produce experiences than does Ecstasy. Just the fact that MDA lasts lasts 3 times as long as MDMA indicates that it is doing "something different" than MDMA neurologically.

Antonmesc said:
Are you a doctor or work in the medical community? because you mentioned "We" when you refered to the medical community,
I'm not a physician, but in the past I've worked in a number of antidepressant research projects (mostly developing computer models for neuro function simulation).

I currently work in medical research related to the public health sector. I work directly with medical doctors (mostly epidemiologists) and biomedical researchers, as a contractor for a government agency that still prides itself on supplying honest ("non-political") information and research to benefit the public ("we" also work closely with health ministries and organizations in other countries, and with institutions such as the World Health Organization).

That's why I'm always harping about public health models and how the NIDA sponsored MDMA research doesn't fit with what we are seeing occur in the population of users.

Anyway, this will be my last post for a while. I've got to get a on plane in a couple of hours as this is the last day of my vacation. It's been nice chatting. :)
 
Sorry to break this to you man, but actaul, honest to god MDMA also produces dopaminergic toxicity in animals.

Brian, people smoke all their lives, quite when they are 80, and go on to live to 100, but that doesn't mean smoking isn't bad for you.

Infact, I'm not awear of a large epidemiological study looking at the cardiovascular function of MDMA users, are you?
 
MDMA is a dopaminergic toxin in mice for some reason. I don't recall any clear-cut evidence of dopaminergic toxicity in rats or primates.
 
Kanthasamy A, Sprague JE, Shotwell JR, Nichols DE. Unilateral infusion of a dopamine transporter antisense into the substantia nigra protects against MDMA-induced serotonergic deficits in the ipsilateral striatum.
Neuroscience. 2002;114(4):917-24
 
Top