Numb19
Bluelighter
I tried searching the forum but was unable to find anything on this.
Now I know there are ways to prevent or slow-down the tolerance with things like DXM/NMDA antagonists, obviously, reversing or eliminating tolerance is the age old mystery with no "magic bullet" and actually no real recourse except abstinence (or tapering).
Apparently, according to a study, L-Tryptophan loading can reverse opiate tolerance:
http://www.ncbi.nlm.nih.gov/pubmed/7454382
Comments? Feedback? Experiences?
Now I know there are ways to prevent or slow-down the tolerance with things like DXM/NMDA antagonists, obviously, reversing or eliminating tolerance is the age old mystery with no "magic bullet" and actually no real recourse except abstinence (or tapering).
Apparently, according to a study, L-Tryptophan loading can reverse opiate tolerance:
Tryptophan loading may reverse tolerance to opiate analgesics in humans: a preliminary report.
Hosobuchi Y, Lamb S, Baskin D.
Abstract
Five patients on chronic opiate medication to treat low-back and leg pain were determined to have developed opiate tolerance on the basis of their failure to obtain significant relief (rated on a subjective pain scale and by the degree of straight leg-raising they were able to endure) after receiving 30 mg of morphine administered i.v. in divided doses over 35 min. After these patients' diets had been supplemented with 4 g/day of L-tryptophan for 2-9 weeks, they achieved significant relief from pain when the opiate tolerance test was re-administered, and were able to lead more active lives while reducing their daily opiate intake. chronic opiate administration probably reduces the serotonin turnover rate in the central nervous system; it may be that this is reversed by loading with the serotonin precursor, L-tryptophan.
http://www.ncbi.nlm.nih.gov/pubmed/7454382
Comments? Feedback? Experiences?