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Miscellaneous Strychnine's association with peyote and LSD

red22

Bluelighter
Joined
Nov 23, 2009
Messages
1,200
The myth that LSD pills/tabs are known to contain strychnine was surprisingly prevalent.[1] There is also a myth that peyote contains strychnine, which makes more sense. I found two quotes that provide insight into the origin of the peyote myth, and it's reasonable to assume that strychnine's association with LSD was just an extension of the peyote one.

THERE are two stages in the physiological effects that result from eating peyote. First, the strychnine‐like alkaloids in the cactus give a feeling of excitement and exhilaration like that induced by strong coffee. The face becomes flushed, the pupils dilate and the person tends to be talkative, light ‐ headed and wakeful. (These alkaloids have been experimented with in pure form because of a possibility that they might be useful in treatment of heart disease.)

The ‘Diabolic Root’. Weston La Barre, Nov. 1, 1964, The New York Times

To put one persistent myth to rest, there is no strychnine in peyote. The white fuzz that is usually removed from the buttons before ingestion can be a gastroirritant, but it does not contain strychnine. However, lophophorine, accounting for about 0.18% of the dry weight of the buttons, can cause some symptoms similar to strychnine poisoning, such as a sickening feeling in the back of the head, and hotness and blushing of the face. Lophophorine causes violent convulsions when injected into rabbits at concentrations of 12 milligrams per kilogram of body weight.

Pharmako/Gnosis: Plant Teachers and the Poison Path. Dale Pendell, 2005, 2009. Peyote: Lophophora williamsii, page 106


Strychnine and/or Nux vomica extract seems to be a well-established drug in Asia, as its effects in low doses are much removed from its higher dose effects. As recently as the 1960s, strychnine was marketed as an aphrodisiac in the U.S.[2] and it is on the World Anti-Doping Agency's Prohibited List.[3]

"Strychnine and brucine although being toxic in nature have remarkable therapeutic action."[4]

There was also a 1965 song by The Sonics called Strychnine that praises it:

You may think it's funny
That I like this stuff
But once you've tried it
You can't get enough


It's reasonable to assume that the description in the first quote derived from researcher(s) who had consumed both peyote and strychnine (seperately). Strychnine is also an indole, like tryptamine psychedelics, and peyote's alkaloids are similar to indoles, so that, combined with the observed convulsions, could have inspired the aformentioned description.

One Bluelighter even describes strychnine as "extremely similar to a non-hallucinogenic dose of acid" and extolls the fact that "since I extract it myself, I know exactly what Im getting (as far as product and dosage is concerned), its infinitely cheaper, and I have constant/unlimited access due to not having to rely on dealers". See all his comments about it on this page: https://www.bluelight.org/community...-as-a-motivational-boost.503184/post-11972780

The description of a redditor who also experimented with strychnine reaffirms this Bluelighter's comment: "My field of vision expanded noticeably. Every object seemed more sharply defined, with deeper shadow variations and color vividness. I also felt like I could zoom in on far off objects. This was like going from 360p to 720p." (Strychnine: my experiences. Aug 6, 2015)

The aformentioned brucine is dimethoxystrychnine and is reportedly less toxic than strychnine and may have even been passed off as amphetamine pills once.

"Strychni semen, a herb also known as “maqianzi” in traditional Chinese medicine (TCM), also contains strychnine together with its less toxic analog, brucine."

Strychnine poisoning due to traditional Chinese medicine: a case series. Tong HF, Chan CY, Ng SW, Mak TWL. F1000Res. 2021 Dec 17;10:924. doi: 10.12688/f1000research.73072.2 (Background)

I also recall that there was a time when "white crosses" were analyzed to be brucine rather than amphetamine.

George Root, Oct 20, 1994. alt.drugs post (UseNet), 'Re: What are the different kinds of LSD?'. Seen at the bottom of this page: Myths: Strychnine in LSD? Lamont Granquist, 1994. https://www.erowid.org/chemicals/lsd/lsd_myth5.shtml


1. Strychnine and other enduring myths: Expert and user folklore surrounding LSD (Presti, D. E., Beck, J. E.) / Psychoactive sacramentals: Essays on entheogens and religion. T. B. Roberts (Ed.), 2001, San Francisco: Council on Spiritual Practices (pages 125-137)

2. Following this trend in France, a company in Miami during the 1960s learned of strychnine’s supposed sexual benefit from the medical writings of the Victorian era. The company, All Products Unlimited, hoped to seize upon the sexual revolution of the 1960s for financial gain by selling an aphrodisiac pill they called Jems. The pill, marketed as a “sex energizer pep tablet for married men and women,” contained a small dose of strychnine.

Following the release of Jems to the general public, All Products Unlimited was sued for mail fraud. The suit was, in fact, not focused toward the inclusion of strychnine in the pill’s formula, but instead was focused upon the false claims of Jems being able to provide sexual benefit to consumers. Upon facing the charges in court, the company decided not to fight it and was swiftly indicted.


[Reference: Kang L, Pedersen N. Quackery: A Brief History of the Worst Ways to Cure Everything. New York, NY: Workman Publishing; 2017.]

Fun Fact: What Benefit Did Victorian Era Physicians Believe Strychnine Could Provide?. Alana Hippensteele, Pharmacy Times, Nov 12, 2020


3. See S6. Stimulants: https://www.wada-ama.org/en/prohibited-list?page=0&q=strychnine&all=1#search-anchor

4. TLC Determination of Strychnine and Brucine of Strychnos nux vomica in Ayurveda and Homeopathy Drugs. Rathi A, Srivastava N, Khatoon S, Rawat A. Chromatographia 67(7):607-613, Apr 2008. DOI: 10.1365/s10337-008-0556-z
 
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Who the fuck on here voluntarily consumed strychnine? That is fucked. It was reportedly used in hot shots back in the day.

Ive heard the lsd strychnine myth but not the peyote one
 
Pretty soon, me. As one might imagine, I have become intrigued by it and I just ordered a Nux vomica tincture from India.

I gotta ask why? I have never heard anything positive about strychnine at all. I mostly know it from being used as a hot shot years ago and it being mentioned in alot of books for that reason. I think Johnny Thunders may have gone out that way actually
 
I would highly recommend having somebody with you who could administer large amounts of benzodiazepines if you begin to seize. There aren’t really any good mechanistic antagonists, so even barbiturates may be touch and go if the overdose is severe.

It’s bad enough that curare is considered a decent treatment for styrchnine poisoning.
 
Interestingly, I had a nightmare, some might say a warning, where I experienced a seizure. I was actually acting out a seizure in my sleep, it woke me up. I think this was after I consumed some in the dream, but all I remember was the seizure.
 
Pharmako/Gnosis: Plant Teachers and the Poison Path. Dale Pendell
great book btw! doubt i would be me if i hadn't read it 20 years ago.

As far as strychnine in peyote... I don't really see how, the plant doesn't really produce tryptamines/tryptamine derivatives.

Also, please don't take strychnine.
 
I read somewhere years ago that Strychnine had a pleasant stimulant effect at low doses. Also said the "window" was pretty small and it was dangerous.
 
“Strychnine is a natural alkaloid derived from the seeds of the Strychos nux vomica tree. Up to the 1970s, strychnine was used in medicines in minute doses (1/10–1/60th of a grain, which is the equivalent of 1–6 mg) for treating stomach ailments and allegedly in sport as a performance enhancing substance. Its use fell out of favour as safer alternatives were developed.”

Strychnine poisoning: gone but not forgotten. Parker AJ, Lee JB, Redman J, Jolliffe L. 2011. Emerg Med J., 28(1):84. doi: 10.1136/emj.2009.080879
 
I downloaded three sports books that talk about that and I wanted to add them to the OP, but they're on my phone, which is starting to malfunction, so I didn't add them.
 
As mentioned in the OP, brucine (dimethoxystrychnine) is reportedly less toxic than strychnine and researchers are interested in using it liposomally and transdermally as a way to mitigate its toxicity. So, for anyone who's interested in the therapeutic or recreational potential of strychnine, these ideas sound ideal. Indeed, the second person quoted about the effects of Nux vomica in the OP stated that an accidental overdose scared him away from it and fantasized about a strychnine derivative that doesn't have side effects.*

Improved pharmacokinetics and reduced toxicity of brucine after encapsulation into stealth liposomes: role of phosphatidylcholine. Chen, J., Yan, G. jun, Hu, R. rong, Gu, Q. wen, Chen, M. lei, Gu, W., … Cai, B. chang. (2012). International Journal of Nanomedicine, 7, 3567–3577. DOI: 10.2147/IJN.S32860


“Traditional Chinese medicine “Ma-Qian-Zi” is a dry, mature seed of Strychnos nux-vomica Linn. Traditional Chinese medicine believes that “Ma-Qian-Zi” has the capabilities of improving microcirculation, detumescence and relieving pain. Modern research shows that the main active ingredient is alkaloids, the content of about 5% of crude drugs, mainly brucine, strychnine and its nitrogen oxides, of which brucine 1% [1]. Brucine is a weakly basic indole alkaloid, molecular formula C23H26N2O4, molecular weight 394 kDa, which is white crystalline powder, slightly soluble in water, soluble in ether, chloroform, ethanol, methanol and other organic solvents and tastes bitter [2–4]. It has good analgesic, anti-inflammatory, anti-tumor and other effects confirmed by related studies [5, 6]. However, it can excite the central nervous system. Recently, it becomes a hot spot in clinic how to give its full play to biological activity while avoiding the central toxicity [7–9].”

Effect of Ultrasound-Enhanced Transdermal Drug Delivery Efficiency of Nanoparticles and Brucine. Zhang, N, Wu, Y, Xing, R, Bo, X, Guoliang, D, Wang, P. BioMed Research Internation, vol. 2017, article ID: 273816. DOI: 10.1155/2017/3273816


It may even have potential as a cancer treatment:

Transdermal delivery of brucine-encapsulated liposomes significantly enhances anti-tumor outcomes in treating triple-negative breast cancer. Wu M, Hu Y, Xu M, Fu L, Li C, Wu J, Sun X, Wang W, Wang S, Wang T, Ding W, Li P. Biomaterials Advances. 2023;153:213566. doi:10.1016/j.bioadv.2023.213566


*“I have heard the aphrodisiac nature of strychnine likened to yohimbine, which I have also taken and enjoyed sexually, but is qualitatively and pharmacological unique from the other. The two actually compliment eachother nicely in that respect. There is a 'classic' aphrodisiac recipe (according to this encyclopedia) that included: yohimbine, methyltestosterone, pemoline, and strychnine. I havent found a compound quite like strychnine in terms of enhancing tactile experience. I don't know if it is purely novel in this respect as my experience is limited, but it is possible to design a derivative of strychnine that does not bind the muscle associated glycine receptors and could theoretically circumvent these side effects.” (Aug 6, 2015, reddit)
 
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I read that it was used as a [performance-enhancing drug] in the early 1900s.

I forgot to mention that the second person with experience, quoted in the OP said that he experienced this aspect of the chemical!

I began to feel jumpy, and really needed to move. So I started my run. Flying through the streets and woods was a different experience. I moved easily and everything felt bright and alive. I beat my old records and ran a mile in under 6 mins. (Strychnine: my experiences. Aug 6, 2015)


I also forgot to mention that another person who tried it replied to that post!

I've done strychnine before myself. I wouldn't say I particularly enjoyed it.

It did give me heightened senses, colors really popped out visually and I felt like I had a much more intuitive sense of spacial awareness. Maybe useful if you're trying to learn how to juggle or something. I can see why olympians used to dope with it, it definitely seems like it improves coordination.

I wouldn't really go out of my way to recommend the stuff, I ended up tossing the Nux Vomica seeds I had stashed. It just made me feel really edgy and like my heart was racing. A little too much anxiety for me.

It smells like some kind of exotic coffee, which was kind of funny to me.

Sure people historically also have used it as a poison to commit murder and whatnot, but that is at much larger doses. Many drugs that are ok at therapeutic dosages are very dangerous at overdoses.


i_am_hathor, Aug 7, 2015, reddit
 
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It certainly doesn't sound that way. It sounds like you guys are just harping on its reputation. It is an indole, which is the same base of tryptamines and kratom's chemicals. As evidenced in post #13, researchers have a current interest in dimethoxystrychnine.
 
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Strychnine was used as a rat poison for years. Later, another commonly used rat poison was Warfarin... a commonly used blood thinner.

Strychnine could be, and was, carefully used as a drug as well. Carefully would be the key word here. The reason it gained notoriety as a poison is the horrible way it kills.

"It produces some of the most dramatic and painful symptoms of any known toxic reaction, making it quite noticeable and a common choice for assassinations and poison attacks."
Wiki - Strychnine poisoning
 
It certainly doesn't sound that way. It sounds like you guys are just harping on its reputation. It is an indole, which is the same base of tryptamines and kratom's chemicals. As evidenced in post #13, researchers have a current interest in dimethoxystrychnine.

Vinculin is an indole derivative, but not something you would want to ingest if you don’t have cancer.

Just because something contains a chemical moiety, it certainly does not mean that the compound resembles all others in that group.

Strychnine is dangerous only because it is a glycine site antagonist. Any other glycine type antagonist with similar kinetics would be just as dangerous.


I wonder how it compares to microdosing like flumazenil or an actual GABA A antagonist like pentylenetetrazole.
 
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