MobiusDick
Bluelighter
Stimulants Of Ahe Future Are Already Here
While perusing some of the posts, I came upon this one and decided that I needed to chime in here. While there are certainly more than two classifications of non-entactogenic stimulants that are drugs of abuse in animal models --and yes that is important because you find individuals who abuse strange atypical drugs that very few people find pleasant-- let's just narrow it down for simplicity's sake and say that abusable stimulants basically fall into two classes based on their interactions with the DAT and the VMAT-2, and whether they have any direct activity themselves at the D2/D3/D4 receptor subtypes: stimulants of the cocaine type and stimulants of the amphetamine type.
Now of the stimulants of the cocaine type, some of the most pleasant compounds ever created have been around for decades, but are relatively complicated to produce due to their extensive chirality, so veritably a handful of drug users have ever tried them and the vast majority of drug users have not even heard of them. These include WIN 35,065-2; WIN 35,428, RTI-121 and RTI-55. Of these, IME, There is no God but WIN 35,065-2 (let's call the others demi-gods.) Also note that none of these drugs lasts incredibly long, with some of them lasting perhaps three times as long as cocaine, but when the drugs last much longer, they tend to lose some of their euphoriant effect. I am not sure that this is absolute with cocaine analogues, but it does not seem to apply to amphetamine analogues: they can last for days.
If you look at the images in the Word doc, you will see all these cocaine analogues are phenyltropanes, but there are some very good analogues made from arecoline which substitutes the ubiquitous piperidine structure (which does appear on tropane if looked at in 3 dimensions.)
As far as amphetamine analogues, I have far less experience with these, but I do find 4MA (4-methyl-aminorex aka Euphoria) very pleasant along with derivatives of nomifensine and aminopropylferrocene . They are very pleasant but they still do not have the magic of cocaine type to me. Great amphetamine analogues that were not created by Sasha Shulgin (or at least synthesized by him) and are not entactogenic are difficult to come across. Most analogues are of lesser abuse potential than methamphetamine. If Shulgin had worked on cocaine analogues, I am sure we would have the equivalent of PIHKAL (Perhaps CAIHKAL. I have commented in the past on writing OIHKAL insofar as a definitive book on opioids, but it would be much more destructive, particularly with the way I tend to look at drug use lately. (i.e., I do not want anyone to die from a book like this which is why I doubt I would write one.)
If any of these compounds ever became widespread and easy to obtain, we would have "epidemics" far greater than the so called meth or crack epidemics (Both aminorex derivatives and cocaine analogues would easily change most stimulant addicts drug of choice, of that I am certain, as I never did these drugs with anyone who did not start to nag me about doing more. I quickly learned to be careful who you share with. If they don't have respect for you, they will try to obtain these drugs at all costs. I know the drug in part has a hand, but the character is also an issue.
MobiusDick
While perusing some of the posts, I came upon this one and decided that I needed to chime in here. While there are certainly more than two classifications of non-entactogenic stimulants that are drugs of abuse in animal models --and yes that is important because you find individuals who abuse strange atypical drugs that very few people find pleasant-- let's just narrow it down for simplicity's sake and say that abusable stimulants basically fall into two classes based on their interactions with the DAT and the VMAT-2, and whether they have any direct activity themselves at the D2/D3/D4 receptor subtypes: stimulants of the cocaine type and stimulants of the amphetamine type.
Now of the stimulants of the cocaine type, some of the most pleasant compounds ever created have been around for decades, but are relatively complicated to produce due to their extensive chirality, so veritably a handful of drug users have ever tried them and the vast majority of drug users have not even heard of them. These include WIN 35,065-2; WIN 35,428, RTI-121 and RTI-55. Of these, IME, There is no God but WIN 35,065-2 (let's call the others demi-gods.) Also note that none of these drugs lasts incredibly long, with some of them lasting perhaps three times as long as cocaine, but when the drugs last much longer, they tend to lose some of their euphoriant effect. I am not sure that this is absolute with cocaine analogues, but it does not seem to apply to amphetamine analogues: they can last for days.
If you look at the images in the Word doc, you will see all these cocaine analogues are phenyltropanes, but there are some very good analogues made from arecoline which substitutes the ubiquitous piperidine structure (which does appear on tropane if looked at in 3 dimensions.)
As far as amphetamine analogues, I have far less experience with these, but I do find 4MA (4-methyl-aminorex aka Euphoria) very pleasant along with derivatives of nomifensine and aminopropylferrocene . They are very pleasant but they still do not have the magic of cocaine type to me. Great amphetamine analogues that were not created by Sasha Shulgin (or at least synthesized by him) and are not entactogenic are difficult to come across. Most analogues are of lesser abuse potential than methamphetamine. If Shulgin had worked on cocaine analogues, I am sure we would have the equivalent of PIHKAL (Perhaps CAIHKAL. I have commented in the past on writing OIHKAL insofar as a definitive book on opioids, but it would be much more destructive, particularly with the way I tend to look at drug use lately. (i.e., I do not want anyone to die from a book like this which is why I doubt I would write one.)
If any of these compounds ever became widespread and easy to obtain, we would have "epidemics" far greater than the so called meth or crack epidemics (Both aminorex derivatives and cocaine analogues would easily change most stimulant addicts drug of choice, of that I am certain, as I never did these drugs with anyone who did not start to nag me about doing more. I quickly learned to be careful who you share with. If they don't have respect for you, they will try to obtain these drugs at all costs. I know the drug in part has a hand, but the character is also an issue.
MobiusDick
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