Stimulants of the Future

[fastandbulbous]

It sounds a lot like MDPV ie almost entiely dopamine reuptake inhibition with a tiny bit of noradrenaline reuptake & bog all effect on the 5HT system

 

[Reminisant B]

Its a bit of a strange molecule, can't really compare it to anything (now realising its not a pro-drug). Such a long, thin shape.

 

[Jamshyd]

RemB: you might be interested in reading this thread: http://www.bluelight.ru/vb/showthread.php?t=251309

Also, try the alternative spelling "Sydnocarb"... it yeilds more results on it on google.

 

[vecktor]

Its a bit of a strange molecule, can't really compare it to anything (now realising its not a pro-drug). Such a long, thin shape.

what chem draw program drew that? is it 3 dimensionally correct? lowest energy or whatever, I am looking for an easy to use free piece of software to do this.

mesocarb/ sidnocarb/ syndnocarb /sydnocarb

 

[Reminisant B]

I'm using ChemOffice2002 which has Chem Draw and Chem3d.

I didn't run any of the tools to optimize it shape so it won't be the best estimate.

I remeber reading a discussion in a blueligt thread about drawing software software, maybe in the MDPV thread, or possibly this one (its getting so big, hard to search through it).

 

[izo]

it was in the mdpv thread:
http://www.chemaxon.com/marvin/sketch/demo.html
a better version can be found here:
http://pharmazie-bonn.de/marvin/sketch-applet2.html

is fencamfamine still available for prescribtion anywhere?

 

[haribo1]

Maybe it's the brain going, but I'm sure that East European runners and such were using mesocarb until it was banned by the Olympic comittee. In fact, I seem to remember reading that there was talk of it being developed by one of the labs that generally worked on stuff to enhance their peoples performance.
As soon as I came across it, I was really interested.

 

[mad_scientist]

is fencamfamine still available for prescribtion anywhere?

South Africa apparantly, probably other places also.

 

[Jamshyd]

I just got an idea. First, check out the structure of Fenethylline (Phenethyline/phenetylline/fenethyline).

Now, the idea is that this breaks down into Caffeine/Theophyline (don't care which) and Ethamphetamine in the body (or Methapmpethamine and an ethylated xanthine). If someone could explain how this breakdown happens, I would appreciate it.

Now... what about this. Since I don't have a chemdraw thingy on hand, I'd like you to visualize that same molecule, but instead of a xanthine, there is another amphetamine molecule there. What would happen in that case?

 

[vecktor]

I just got an idea. First, check out the structure of Fenethylline (Phenethyline/phenetylline/fenethyline).

Now, the idea is that this breaks down into Caffeine/Theophyline (don't care which) and Ethamphetamine in the body (or Methapmpethamine and an ethylated xanthine). If someone could explain how this breakdown happens, I would appreciate it.

Now... what about this. Since I don't have a chemdraw thingy on hand, I'd like you to visualize that same molecule, but instead of a xanthine, there is another amphetamine molecule there. What would happen in that case?

I believe fenethylline hydrolyses to amphetamine rather than N-alkylated amphetamine.

 

[Reminisant B]

Now... what about this. Since I don't have a chemdraw thingy on hand, I'd like you to visualize that same molecule, but instead of a xanthine, there is another amphetamine molecule there. What would happen in that case?

You mean this?

Don't know if it exists, like the idea. Would the molecule have a tendancy not to break apart into the two molecules though due to differing chemisty. (?)


I remember reading fenethyline is surprisingly hard to synth.

 

[Morninggloryseed]

Fenethylline is metabolised by the body to form two drugs amphetamine (24.5% of oral dose) and theophylline (13.7% of oral dose), both of which are active stimulants themselves. The physiological effects of fenethylline therefore result from a combination of all three drugs.

 

[fastandbulbous]

^ There are quite a few drugs out there that are basically prodrugs for amphetamine/N alkylamphetamine. Benzphetamine is metabolized to methampetamine & amphetamine

 

[fastandbulbous]

Just in case people out there are getting too excited at the prospect of all sorts of new stimulants, here's a sobering little paper about 'when stimulants attack'


I found that little gem while looking for a paper about pipradrol analogues & derivatives

 

[jah]

Well that's a reality check for all abusers!

 

[Jamshyd]

RemB: Yes, thanks for the drawing, thats exactly what I had in mind.

Would this be broken down like Fenethyline?

And would it be considered an amp. analogue legally?

MGS and F&B: Thanks a lot for the info

 

[johanneschimpo]

^ I would assume its an analogue since when you look at it, it's still just (meth)amphetamine with a large substition [which happens to be another '(meth)amphetamine' "moiety"] in place of the methyl group alone.

I hope that makes sense and doesn't sound arrogant. Also I can't believe I used the word moiety, I hope I used it correctly.

 

[fastandbulbous]

Has anybody any data on 3-methyl-1,2,3,4-tetrahydroisoquinoline, sort of like methamphetamine bent around until the methyl group is part of the aromatic ring?

Another's I've weaseled out are 2-amino-1,2-dihydronaphthalene which is reported at 1/4 potency of dexamphetamine (so about 1/2 that of racaemic amphetamine) with the tetrahydro derivative (2-aminotetralin) being about 1/8 the potency of dexamphetamine (1/4 racaemic)

 

[Langevin]

2-amino-1,2-dihydronaphthalene? Am I missing something? How can there be a hydroxy and amino group at the same position on a naphthalene ring? Ahhh...I get it, half of the naphthalene ring is partially saturated.

Confusing nomencalture. Anything with naphthaline in it makes me cringe, an irrational fear of naphthaline...

Interesting that the removing the of other double bond in 2-amino tetralin leads to a decrease in potency. I wonder what 2-amino-decahydronaphthalene would be like. Heinous would be my guess.

 

[nuke]

It was mentioned earlier that a human assay of 2-AT had been nothing short of disastrous, so proceed cautiously through the bicyclic amphetamine analogues.