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Stimulants of the Future

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The N-desmethyl version of 2,4-dimethoxymethamphetamine is in PiHKAL, but
N-methylation does not affect the 3,4's the 3's or the 4's although it does disenable the 3,4,5's and the 2,4,5's.

got it?
great !!!

8o
 
fastandbulbous said:
Yeah, I know someone who produced a whole series of alkanone derivatives and his favourite was 1-phenyl-2-methylamino-1-butanone. I think it's that it has a small amount of noradrenergic activity coupled with a lot of dopaminergic activity, which seems to be the right combination for maximum euphoric effects
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So, the 3 carbom (methcathinone) is 'crap' but the 4-chain analogue is good?
 
haribo1 said:
So, the 3 carbom (methcathinone) is 'crap' but the 4-chain analogue is good?
Click to expand...

Yeah, apparently the degree of dopaminergic reuptake inhibiton increases with chain length up to a 6 carbon chain - thing is the effects on the noradrenergic system go down with increasing chain length (which is why MDPV is almost exclusively dopaminergic in action). If you want euphoria as opposed to something for attention/focus control, you need some adrenergic activity
 
fastandbulbous said:
Yeah, apparently the degree of dopaminergic reuptake inhibiton increases with chain length up to a 6 carbon chain - thing is the effects on the noradrenergic system go down with increasing chain length (which is why MDPV is almost exclusively dopaminergic in action). If you want euphoria as opposed to something for attention/focus control, you need some adrenergic activity
Click to expand...

Wow, so it's a 1-pot thing to make from propio butiophenone, bromine, methyl amine and some solvents. It would be legal in the UK as well. Whats the dosage?
 
About 10-20mg for 1-phenyl-2-(N-methylamino)-1-butanone - that's from memory. Give me a mo and I'll have a rummage and see if I can verify that .

I do remember that it seems to have the right dopaminergic/noradrenergic activity to produce a reasonable amount of euphoria - a lot better than methcathinone, which I've found can leave you feeling a bit 'jittery' (I'd guess down to adrenergic activity). Of course if you bung a meyhtylenedioxy ring onto it, you still end up with an entactogenic like activity. That's quite unlike the 5 carbon valerophenones that disp;lay almost no such erffects (MDPV causes some colour brightening.enhancement with higher doses, but very little else).

The pyrrolidine version of the butyrophenone didn't get made (or I wasn't informed or have forgotten) so I don't know quite what that would be like; mind you, the pyrrolidine version of the propiophenone (like a cyclicized version of diethylpropion) is a more potent CNS stimulant compared with diethylpropion for the same amount of anorectic activity (German patent in Chem Abstracts) which is most [robably why it was rejected in favour of diethylpropion for the final product. That sort of implies that 1-phenyl-2-(1-pyrrolidyl)-1-butanone might be the one to go for

In the end you can only apply the 'suck it and see' test for final assessment
 
"Of course if you bung a meyhtylenedioxy ring onto it, you still end up with an entactogenic like activity."


That would be the Mebylone.
 
I must say I liked Methcathinon,only second to meth.Altough it has more of the manic repetitive stuff when going higher with doses (repeated).
But on some level I think it has emphatogenic/"window opening" qualities,probably serotonergic in nature,at least it felt a bit like MDMA when I tried 50mg Methcathinon orally,only without the visuals.

If the butyrophenon analog is even better,well...
 
Actually, today I got to play around with 2-(alpha,alpha-diphenylmethyl)piperidine - the one Shulgin mentions in 'Future Drugs of Abuse' as possibly being as potent as methamphetamine. Well yes & no; yes it's a strong locomotor stimulant with a long action, but no, it's not as euphoric as meth and has virtually no peripheral symptoms such as raised heart rate, sweating or dry mouth. As I mentioned to someone, 5mg had me marching around like I was ready to invade Poland =D , but it's difficult to gauge quite where your head is at because of the lack of peripheral symptoms to use as a measuring stick. It has a very, very clean feeling with a very positive feeling of being able to focus on a task (it's a dopamine reuptake inhibitor) and of having a lot of useable energy; the one thing that seems totally absent though is the effect on libido that say meth or MDPV has (which isn't a bad thing as it's difficult to not get distracted by all things sexual these days with MDPV).

I may write a report on iy, or leave it for a few days until I can beter get a measure of the stuff (who am I kidding, I feel like doing things like it's the first day of spring at the moment!). I'd say that Shulgin wasn't too wide of the mark with this stuff,


PS So far I've had it referred to as 2-DPMP, but for a roll of the tounge name, I like desoxypipradrol (desoxy meaning having an oxygen atom removed, the same way methamphetamine used to be referred to as desoxyephedrine).
 
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was it 2-(alpha,alpha-diphenylmethyl)piperidine which was discontinued in studies due to the extreme variation in individual sensitivity to the compound which appeared in trials: shaking etc at low doses?

there are a couple of interesting dopamine reuptake inhibitors which are based on the related pyridine rather than the piperidine, for example 4-(alpha alpha diphenylmethyl) pyridine is equipotent with cocaine, it also appears that the 2 pyridine is also an active stimulant. all of these substances are commercially available, though I have no idea what they are used for.

This sort of leads into the lefetamine discussion elsewhere as replacing one phenyl with a benzyl group in both of the above compounds leads to an active DAT and NE reuptake inhibitor in a way a distant analog of lefetamine.

I believe that 4-benzyl pyridine or was it the piperidine has come up in discussion, it appears that 4 benzyl pyridine is almost inactive as a DAT inhibitor.

methyl 3-phenyl-norbornane-2-carboxylate might be an interesting substance, a non nitrogenous analogue of the great substance fencamfamine.. it fits with the SAR for DAT inhibitors. though the methyl ester might have to be replaced with a terminal amino alcohol to increase water solubility.
 
Doesent sound like its non-euphoric,first day of spring,my dear...We just got 20cm of snow...
 
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