I can see how meth and crack can cause long lasting health issues. Same with opioids. The drugs change us in so many ways.
I have had a few senior pharmacists explain that as we get older our body go through changes. They stated as an example, a patient can have a huge tolerance to opioids throughout their whole life by taking a large daily dosage. At some point once patients reach a certain old age, the opioids have an opposite effect all of a sudden becoming stronger and risky towards health. I wasn't obviously trying to hear this nor accept that to be my fate. However, it does make a little sense if we are talking about getting into the ages of 65-70.
In the upper years our bodies really lose strength in many different ways and what was once a thing is a thing no more. I have been on Rx opiates & opioids for going on 38 years now. I seriously doubt I will experience life without them regardless of pain levels. My doctor and I believe my brain will not return to normal and I will be stuck in a endless PAWS mind frame and the depression & not being able to produce dopamine along with other brain chemicals can spiral into a rapid decline of motor function with CNS issues. Parkinson's disease is a strong possibility because of the dopamine issues as it runs in my family. My grandfather died from Parkinson's.