I switch back and forth from St. John's Wort and 5htp. Well, not really, I just use them each in a different manner. I have lately been taking St. John's Wort regularly and I like the affects. I kind of thought 5htp was starting to fuck with my head a little bit. My rolls just did not seem as good. But I do not have any evidence, just personal opinion. But I do know that I have been taking St. John's Wort regularly (200mg a day) and my rolls have been incredible! And I seem to get less of the intense head pain that usually creeps on a couple of days afterward....by the way, does anyone else get that (maybe i will post that question because i am curious)? But I like to take 5htp if I can't get to sleep at night, even though my dreams are always incredibly freaky! For that same reason I do not like to take it (5htp)during the day...it makes me sleepy. You should just experiment with both and figure out which you like best. Maybe I had just started to go way overboard with the 5htp. Who knows! Good luck...and now reading back over this, it is probably of no help at all. Sorry!