• N&PD Moderators: Skorpio | someguyontheinternet

St John's Wort - Is it an Inhibitor or Inducer for Opiates?

Oh, yeah - I read that and found several other studies all suggesting the same thing - SJW in fact does not have any effects on CYP2D6 but does have effects on CYP3A4.

SJW is purportedly listed on that CYP450 table as a CYP2D6 inducer because it has demonstrated a clinically significant ability to induce CYP2D6, but I can't find any corroborating research for this. Bummer.
 
I've been taking the Wort for several weeks now, and have delved into my hydrocodone routine as usual throughout. Strangely it seems hard to even catch a buzz at this point. There definitely is one, but it isn't as pronounced, and there is no flood of euphoria in the first hour that I'm so used to. With that in mind there's almost no point in continuing to try in vain, I figure it to be a waste. I mean considering that they are all 325's now I wasn't afraid to eat 6 of 'em at a time, I mean 60mg would always get me off good even with a decent tolerance, so to me it's obvious it reduces the effectiveness of hydrocodone. Now on the other end of the spectrum....the good news....In all my years of opioids I've cycled on and off. Due to that, I could be clean for a couple/few days, take maybe 30mg for a few days in a row, and I'd get minor withdrawal every time no fail....first day a little fatigue and yawns at the end, then the next two days irritability, squirmy guts, and aching back, that would never completely resolve cause I'd start the cycle over. Anyways with the St. John's Wort, there has been almost a complete absence of withdrawal symptoms. I always have stomach issues, but there is no back pain, and no irritability (I think those last 2 feed off of each other). Feels like a miracle (maybe it just blocked the hydrocodone and prevented a buildup of physical dependence? )
 
https://en.wikipedia.org/wiki/St_Johns_Wort underwent a major pharmacology overhaul sometime within the past few months. The pharmacodynamics are up to date.
In a nutshell, it stabilizes monoamine/glutamate/gaba reuptake/signaling via its ion channel target. Its also a RLY potent anti inflammatory compound.

Replying to OP: probably won't affect opiate drugs beyond pharmacokinetic interactions.
 
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