SSRIs and neurotoxicity/hangover

[badrobot114]

I've been wondering about using SSRIs 3-4 into a roll to mitigate neurotoxicity as shown to be effective in some animal models. However, the research data I came across is inconclusive about how effective it is when taken after MDMA so I wondered if anyone here knows of anything conclusive on the matter through research/self experimentation.

 

[lovepsychadelics]

The general opinion is that MDMA experience is reduced by SSRI's. I've taken 30 mg Avanza on 20+ mg 2ce and fell over standing upright at a convenience mart. It was not a good experience at all, massive cerebral pressure. Seems like your going to do more damage by increasing the level of serotonin in the psynaptic cleft and preventing it from degrading. So your A: releasing serotonin and at the same time B: preventing it degrading and being reabsorbed etc. MDMA= serotonin releasing agent SSRI= well the name says it all. Combination = possibly unpleasant.

That said if taken AFTER the effects which is what I assume your post is asking it will indeed mitigate or reduce the effects. I've taken avanza to reduce HPPD after a trip. I've also used it to end a trip with varying degrees of success as outlined. Some experiments yielded more favorable results! Namely any of those I didn't use it to reduce a 2ce experience.

 

[badrobot114]

Obviously I mean taking an SSRI 3-4 after an MDMA dose to mitigate neurotoxicity and hangover. As we now know, a by product of the interaction between alpah-methyldopamine and gluthatione enters the serotonergic axon through the SERT and shrivels it, causing the "neurotoxic" effect. The proposed logic behind using an SSRI is to block the access to the SERT and thus stop this metabolite from entering the axon.

I've read a research that showed how a MAO-B inhibiting dose of l-deprenyl(say 1-2mg) prevented neurotoxic effects in an animal model that received it prior to MDMA compared to the controls which were given MDMA without l-deprenyl - further supporting the theory that a metabolite broken down by MAO-B(like alpha-methyldopamine) is responsible for the damage.

Anyway, back on point, I understand that your experience is that an SSRI taken 3-4 into a roll does indeed mitigate the hangover(nvm about terminating the effects, at that point i've had my fun ).

 

[JWills20]

Seems like your going to do more damage by increasing the level of serotonin in the psynaptic cleft and preventing it from degrading. So your A: releasing serotonin and at the same time B: preventing it degrading and being reabsorbed etc. MDMA= serotonin releasing agent SSRI= well the name says it all. Combination = possibly unpleasant.

This is a common misconception about SSRI's & MDMA. If the SSRI has been regularly self-administered before the MDMA is taken, it will block the MDMA from working. This is because the SSRI has binded to the same 5-HT sites that MDMA wants to bind to. As a result, the MDMA comes along and tries to do it's thing but gets cockblocked by the SSRI that's already there. So it just floats around for a while doing it's other stuff but having no real impact on serotonin and therefore the experience is dulled.

That said if taken AFTER the effects which is what I assume your post is asking it will indeed mitigate or reduce the effects. I've taken avanza to reduce HPPD after a trip. I've also used it to end a trip with varying degrees of success as outlined. Some experiments yielded more favorable results! Namely any of those I didn't use it to reduce a 2ce experience.

The same mechanism I mentioned is why SSRI's are hypothesized to mitigate neurotoxicity. They will bind to the 5-HT depleted sites and block the potentially dangerous DA free-radicals from getting in there, oxidizing and causing damage to serotonin cells. The timing would appear crucial for maximizing the clinical efficiency. Ideally you want the SSRI to become psychoactive on the MDMA comedown, when the 5-HT cells are most vulnerable.