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So, have just snorted three 20mg Oxycontin pills and...

^ I don't understand what you mean. As in, 13 boxes a year instead of 12? I guess that makes sense because there are more then 28 days in a standard month but that would apply to all sorts of medications that are meant to be taken daily.
 
I guess santa69 means because they've changed from 30 to 28. So people taking it daily now need to buy an extra box a year. This is shit if the price didn't go down the same percentage, I have no idea if it has or not.
 
they've always come in boxes of twenty with my prescriptions - 10 days supply at 1 b.d; 3 x 20's for a months supply. this is at bulk billing surgeries as well.

though i'm sure from what the doctor was saying the other day they've just changed over to 28 even though he only gave me a weeks supply instead of the fortnight supply - but you know the story of the incompetency of that guy;) i'll be seeing the other dude's name you told me about who i can't mention in the future not the other one i initially though. and i'll be asking for a months supply saving me the hassle of having to see him every fortnight as he's willing to give me repeats on my diazepam scripts.
 
yeah thats what i was getting at maybe not all meds but most ive seen now they just box em as 28 so there's need for the 13th one and i wouldnt have a clue on the price percentage i got health care :P lol the 5.60 special
 
Whats the min amount of pain that you could realistically expect a doctor to prescribe an oxycodone/contin preparation for? Back pain?

Pain is such a subjective thing and it seems like either you have an oxy happy doctor or you dont. Or you're a good actor.
 
^ good luck. without that post turning into a sourcing post...
MRIs, X-rays, CT scans showing you a condition that is easy to prove on paper and reports.

doctors are so scared at prescribing addictive and watched medications that so many people spend years going through random medications that may have an effect unless there is blindingly obvious reasons for pain

after getting an MRI on my back showing various issues with numerous discs in my lumbar which (in the neurologists words) may have some effect on numerous nerve roots and sites, i keep getting told that it's normal for nearly all the population to have similar issues.
luckily cymbalta helps with the nerve pain, so thats a positive, but many people go without adequate pain relief in legit cases cause their GP has had their balls cut off by the practice admin and insurance.

your post is bordering on sourcing, but its important for people to understand they dont hand them out for a headache or and sore back - not even in pain management.
 
It seems to me age and sex has a lot to do with it to. Not just with oxy but with benzos. If youre a middle-aged woman (MaW) you can pretty much get whatever the fuck you want. Admittedly Im drawing this conclusion from an absurdly small samply with questionable external valitidy, however I have a few data points on my graph based on different MaW and different doctors prescribing benzos and endone, while harboring a blanket bias that everyone else (especially young intelligent males) are doctor shoppers.
 
In comparison to oxys how does a 40mg iv shot of morphine fair?

I only got a quick rush and a large amount of euphoria
 
Mr Blonde said:
You could try and alter it's metabolism in the body;from the quick look at my chart oxycodone is majorly metabolized by CYP2D6, which can be inhibited by diphenhydramine (Unisom Sleeping Gels, Travacalm Original)and dexchlorpheniramine (Polaramine) among other, mainly prescription only, drugs.
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Is it not the case that CYP2D6 converts oxycodone into oxymorphone (a good thing) but CYP3A4 converts both into inactive metabolites (a bad thing)? Given that both oxycodone and oxymorphone are active, would it not just be better to inhibit CYP3A4?

rachamim said:
You feel it because codeine is internally converted to morphine via a process known as O-demethylation. So, promethazine greatly enables this process.

It doesn't work for oxycodone though, sorry. For that matter, neither does grapefruit.
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Grapefruit juice should extend the experience, surely, through reduce metabolism of the morphine? That's if morphine rather than codeine-6-glucuronide is responsible for the major effects. Recent research seems to conflict with the conventional view that it's solely down to the morphine produced.

Not intending to be an arse, but have been researching this heavily recently. If I'm wrong, an explanation would be appreciated!
 
^ The amount of oxycodone converted into oxymorphone is negligible. I don't have time to find the studies showing this, but I wouldn't worry about missing out on that in it's effect.

Regarding the second point, I will have to come back to that later but I am thinking along the lines of getting information on renal excretion with and without alteration of the CYP3A4 enzyme.
 
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