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So Has Anyone Here Actually had a Chance to Play with Herkinorin

Hammilton said:
I wouldn't say that I have the means. I'm simply friends with those who have the means. It's completely different. One thing to do something yourself, another to ask someone to do it for you.
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Ok, granted.

So then it would be more accurate to say that herkinorin doesn't interest you sufficiently for you to ask your friends (who could easily produce this), to do this for you. Correct?

Very interesting about the increased analgesia in female primates vs. males. Such bullshit-women get all the fun.
 
swilow said:
^Yeah, I've heard childbirth is a walk in the park.
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Well....the pain of childbirth is referred to as the "curse of Eve"- an apparent eternal punishment for the female (Eve), tempting Adam with the "forbidden fruit" in the Garden of Eden. We reap what we sow.......
 
I don't think a myth on par with Santa Clause and the Easter Bunny has any real effect on human evolution.
 
Ha, ok, maybe, well, it primarily targets mu receptors? Which are found predominantly in the PNS, it would have stronger peripheral properties based purely on that. If it targeted DORs, it would have stronger CNS effects.
 
Trains said:
Ha, ok, maybe, well, it primarily targets mu receptors? Which are found predominantly in the PNS, it would have stronger peripheral properties based purely on that. If it targeted DORs, it would have stronger CNS effects.
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Nonsense.

Peripheral mu opioid receptors do not produce noticable effects. You can down gallons of non-CNS permeable opioids like loperamide and not get any noticable effects, except pain from your torn rectum.

If it targeted DOR you would definitely not have stronger CNS effects. A highly selective MU agonist will be far more enjoyable than a selective DOR agonist. In fact, at last check, I'm not aware of a self administered DOR agonist. Many produce seizures, though this isn't absolute with DOR agonists for some reason.
 
Hammilton said:
Nonsense.

Peripheral mu opioid receptors do not produce noticable effects. You can down gallons of non-CNS permeable opioids like loperamide and not get any noticable effects, except pain from your torn rectum.

If it targeted DOR you would definitely not have stronger CNS effects. A highly selective MU agonist will be far more enjoyable than a selective DOR agonist. In fact, at last check, I'm not aware of a self administered DOR agonist. Many produce seizures, though this isn't absolute with DOR agonists for some reason.
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Wrong. Eating huge amounts of loperamide will *definitely* make you drowsy as hell, and it'll give you croaky-opiate-voice, too.
 
And without blind, placebo controlled experiments, I'll still take the placebo controlled experiments. There are lots of reasons why a few people would experience effects (while the rest of the world reports nothing)

And you're arguing for central effects, which doesn't exactly contradict what I've said.
 
How is it possible that this thread somehow joined the ranks of the 700 others that somehow degenerated into a loperamide debate??;)

But seriously, I wouldnt mind this one getting back on task. I'd still love to hear any reports from anyone who has first hand experience with herkinorin.
Could it be that no one on this forum has tried this one?

For the record, Im not expecting miracles from this odd-ball. My guess is that it is barely recreational, but I could be wrong. It's just the novelty of this opioid that interests me. -DG
 
^Seconded!

Loperamide-talk will only lead to the shutdown of this thread. Back on topic please. An answer to the original question (read: detailed report) would be interesting.

:::Murphy
 
Hey all.
Thought I would join this site and post my experiences.
A few months back, a friend of mine ordered 2mg of herkinorin from a reliable source.
It came in a sealed styrofoam container with cold packs around it (it seemed legit I guess is the point I am trying to make).

Neither of us had any idea how to take it though...some people say it crosses BBB, some don't, some say to smoke, some say to inject, some say it needs to be disolved in DMSO...whatever

So he dumped the bottle out on a mirror and split it up into two piles.
He put his half into a crack stem kind of pipe and tried to smoke \ vape it.
He inhaled, held it in for 30 seconds, and exhaled. He could definitely taste it...weird chemically taste.

Anyways, he felt absolutely NO effects.

So..neither of us are sure what went wrong..but here's the questions that went thru my mind after trying it...

1.) Was it really herkinorin?
2.) Did he take it the wrong way?
3.) Was the dose high enough?
4.) Is it not that great of a recreational substance?

I am 99% sure the anwer to 1 is yes, but any of the other ones are up in the air. I know this prob. wasn't the info anyone who's interested in herk. is looking for, but I would love to hear anyone else's experience with it??
 
srgyz said:
1.) Was it really herkinorin?
2.) Did he take it the wrong way?
3.) Was the dose high enough?
4.) Is it not that great of a recreational substance?
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From your description of the packaging and the fact it only came in a 2mg amount it sounds like it was from a legit lab chemicals supplier so the answer to (1) is almost certainly yes.

In regards to the other questions, if it melted down and vapourised cleanly instead of burning black and tasting foul then the chosen route was probably ok.

Most likely the issue is with (3) and (4), probably 1mg was not a big enough dose as even though herkinorin may be 100x more potent at mu than salvinorin A, remember that salvinorin A is extremely weak at mu so 100x stronger may still not be that strong. Also as others have said above there may be issues with BBB penetration in which case it might not be recreational at all, at least in any reasonable dose range.
 
In terms of the theory to reducing opioid tolerance for herkinorin; what means to that ends does herkinorin (via beta arrestin?) do that differs from its theory to that of the DAMGO peptide theory of its method to reducing opioid tolerance?
 
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