SNRI and SSRI use with MDMA

[Pissed_and_messed]

So, I moved derailed conversation from antipsychotics thread to this little thread we've got ready here.

 

[emkee_reinvented]

Persona

Not to be rude, but the source is common sense. You are mixing a serotonin releasing compound (MDMA) with one that prevents its reuptake... I really don't feel a source other than common sense is needed here, but I will try to find one for you later this evening when I have more time.

Peace.

Personal experiences of people are less important or irrelevant ?

Knew one idiot on SSRI s that insisted keeping up his MDMA addiction.
His brain must as fried as that of Brits, he was hardcore.
But when he took MDMA nada happened, i knew he didn t get it.

He figured it out, never got SS btw never afaik.
Not from combining MTA, MDMA and Amphetamine.
So not your average guy. Not from SSRI and humongous amounts of pills.

Finally he got it stopped 3 days for hand to experience a tuned down roll.
He was fried anyway.

My experience, the other way around was very clear.
Take a SSRI on MDMA, soon as it kicks in end MDMA.
As it blocks the re uptake transporter and any leftover bits of Serotonin.
Seem hardly a trigger for SS, but the combination sucks,
and ain t worth the possible risk of SS so don t. Period.

 

[ShulginsReincarnation]

Personal experiences of people are less important or irrelevant ?

Knew one idiot on SSRI s that insisted keeping up his MDMA addiction.
His brain must as fried as that of Brits, he was hardcore.
But when he took MDMA nada happened, i knew he didn t get it.

He figured it out, never got SS btw never afaik.
Not from combining MTA, MDMA and Amphetamine.
So not your average guy. Not from SSRI and humongous amounts of pills.

Finally he got it stopped 3 days for hand to experience a tuned down roll.
He was fried anyway.

My experience, the other way around was very clear.
Take a SSRI on MDMA, soon as it kicks in end MDMA.
As it blocks the re uptake transporter and any leftover bits of Serotonin.
Seem hardly a trigger for SS, but the combination sucks,
and ain t worth the possible risk of SS so don t. Period.

Never said that personal experiences of people are less important or relevant, but if you scour the internet you will find mixed reports indicating that its quite possible for serotonin syndrome to result from the combination. Or, if not, many of its symptoms at very least seem to be present in users of this combination. But, then again, many others say that this didn't occur. My point was that its a risk factor for the development of such, and (in a harm reductionist type of view which I wrongly assumed all of the staff of this forum would have themselves) I simply stated that the combination of such shouldn't be advised. This is when people got upset that I called into question their personal opinions on the matter in favor of science and started insinuating that I was offended or angry when in actuality all I was was disappointed in people for favoring their personal opinions on drug combinations over scientific fact.

Did the individuals attacking me for stating facts and doing research on their behalf raise valid points regarding the science behind it? Yes, but there is no need for them to attack someone for pointing out that there is a lack of complete and total understanding, and even more so there is no need to be telling people something is safe when in actuality we truly are not sure. In the future I am just going to ignore those two as they don't seem to share the same goal of limiting harm to drug users that I have. Again, it just disappoints me that this is the case is all (no offense taken. Its kind of like having a mentally handicapped person calling someone a retard for example... Would you be offended by that? Me neither; if anything its quite humorous in that specific case. Seems like something out of a movie or television show tbh lol)

Seem hardly a trigger for SS, but the combination sucks,
and ain t worth the possible risk of SS so don t. Period.

That was my whole point I was making, and then staff members wanted to interject their opinions about the combination being safe into the chat and when presented with scientific facts they declined to even so much as look into any of what I so graciously provided them in terms of such. Then, when I went through the extra effort of doing the research for them and explaining it to them like they are 5, at least one of them said they didn't want to talk to me (again, like they are 5. Heh.) So, I cannot ignore them like I can other members on these forum through the ignore function as they are staff, but I surely will not engage them in the future since they do not share the same values I have which include being open-minded, patient, and helping limit the risks of drug use in the general population. I repeatedly have had negative interactions with at least one of them for whatever reason, so its probably best I ignore them anyway. Then, seeing as they are buddies apparently, its best to ignore both; birds of a feather you know what I am saying?

Anyway, thanks for not being a knob-head about the discussion. I appreciate your input.

 

[emkee_reinvented]

Never said that personal experiences of people are less important or relevant, but if you scour the internet you will find mixed reports indicating that its quite possible for serotonin syndrome to result from the combination. Or, if not, many of its symptoms at very least seem to be present in users of this combination. But, then again, many others say that this didn't occur. My point was that its a risk factor for the development of such, and (in a harm reductionist type of view which I wrongly assumed all of the staff of this forum would have themselves) I simply stated that the combination of such shouldn't be advised. This is when people got upset that I called into question their personal opinions on the matter in favor of science and started insinuating that I was offended or angry when in actuality all I was was disappointed in people for favoring their personal opinions on drug combinations over scientific fact.

Did the individuals attacking me for stating facts and doing research on their behalf raise valid points regarding the science behind it? Yes, but there is no need for them to attack someone for pointing out that there is a lack of complete and total understanding, and even more so there is no need to be telling people something is safe when in actuality we truly are not sure. In the future I am just going to ignore those two as they don't seem to share the same goal of limiting harm to drug users that I have. Again, it just disappoints me that this is the case is all (no offense taken. Its kind of like having a mentally handicapped person calling someone a retard for example... Would you be offended by that? Me neither; if anything its quite humorous in that specific case. Seems like something out of a movie or television show tbh lol)




That was my whole point I was making, and then staff members wanted to interject their opinions about the combination being safe into the chat and when presented with scientific facts they declined to even so much as look into any of what I so graciously provided them in terms of such. Then, when I went through the extra effort of doing the research for them and explaining it to them like they are 5, at least one of them said they didn't want to talk to me (again, like they are 5. Heh.) So, I cannot ignore them like I can other members on these forum through the ignore function as they are staff, but I surely will not engage them in the future since they do not share the same values I have which include being open-minded, patient, and helping limit the risks of drug use in the general population. I repeatedly have had negative interactions with at least one of them for whatever reason, so its probably best I ignore them anyway. Then, seeing as they are buddies apparently, its best to ignore both; birds of a feather you know what I am saying?

Anyway, thanks for not being a knob-head about the discussion. I appreciate your input.

Don t combine not worth the risk of SS or at best no effects.

Btw Fluvoxamine also a SSRI, you should due to enzyme inhibition.
On this be careful with any combo med or drug, and not combine with MDMA !,
as it needs that enzyme for breakdown. Another contraindication.
Enzyme inhibition of all those S[N]SRI s.
Worth also checking as they could exacerbate SS.

"Fluvoxamine inhibits oxidative drug metabolising enzymes (particularly CYP1A2, and less potently and much less potently CYP3A4 and CYP2D6, respectively) and has the potential for clinically significant drug interactions"

https://pubmed.ncbi.nlm.nih.gov/8846617/

 

[emkee_reinvented]

Anyway, thanks for not being a knob-head about the discussion. I appreciate your input.

The only reason i took a SSRI after MDMA,
was that story it prevented neurotoxicity.

Thought i was smart but looking back,
bit of a retard doing experimenting pseudoscience on himself.

Saw Coke mentioned, powerful direct acting SRI.
In your system you have to sit it out, the Coke.
Totally kills it MDMA, as its short acting later the roll will come up.
Muted, but back, if lucky.

 

[LucidSDreamr]

Not to be rude, but the source is common sense. You are mixing a serotonin releasing compound (MDMA) with one that prevents its reuptake... I really don't feel a source other than common sense is needed here, but I will try to find one for you later this evening when I have more time.

Peace.

MDMA is also a serotonin reuptake inhibitor in addition to opening the flood gates of SERT.

A quick google scholar search will confirm this and also go into the mechanism of how SR happens with mdma.

Anytime my friends gf on SSRIs would try mdma or meth it would not t work for her and she’s have dysphoria and vomitting

 

[ShulginsReincarnation]

Anytime my friends gf on SSRIs would try mdma or meth it would not t work for her and she’s have dysphoria and vomitting

That's pretty much what I would expect in a large number of cases with this combo. The meth though is interesting though. I am wondering if she is on fluoxetine which also acts as a weak DRI. This is the SSRI that typically causes many physically uncomfortable side effects for the first few weeks for patients, and I often attribute this to the DRI effect which is not present with other SSRIs. I, myself, cannot tolerate it for this reason; makes me nauseated and dysphoric (plus all SSRIs make me feel suicidal after about a month or so of use, but that is another thing entirely to discuss.)

 

[LucidSDreamr]

That's pretty much what I would expect in a large number of cases with this combo. The meth though is interesting though. I am wondering if she is on fluoxetine which also acts as a weak DRI. This is the SSRI that typically causes many physically uncomfortable side effects for the first few weeks for patients, and I often attribute this to the DRI effect which is not present with other SSRIs. I, myself, cannot tolerate it for this reason; makes me nauseated and dysphoric (plus all SSRIs make me feel suicidal after about a month or so of use, but that is another thing entirely to discuss.)

It was fluoxetine

 

[Didgital]

explaining it to them like they are 5

yeah that's not condescending at all. Even if @Pissed_and_messed is/was wrong, and even if your right, you come off as condescending and needlessly aggressive in many of your comments. Both of you can easily agree to disagree, but you both keep escalating to the point of insulting each other. I'm tempted to just close the thread, but there's a lot of good information in it.

Anyway this thread is way too dense to read and comment in entirety at this moment and I need to get some asap sleep so I'll try and come back to it.

 

[Pissed_and_messed]

yea my defensive got unnecessarily tempered at times.

 

[ShulginsReincarnation]

yeah that's not condescending at all. Even if @Pissed_and_messed is/was wrong, and even if your right, you come off as condescending and needlessly aggressive in many of your comments. Both of you can easily agree to disagree, but you both keep escalating to the point of insulting each other. I'm tempted to just close the thread, but there's a lot of good information in it.

Anyway this thread is way too dense to read and comment in entirety at this moment and I need to get some asap sleep so I'll try and come back to it.

Oh. You know that is interesting that you say this because in Uni communications class I was taught to match the tone and inflection of my audience, that this is the most effective means of communicating. And, to expand on that thought, he isn't the only moderator/staff here that speaks to more junior members this way. So, especially in the manner which sociology teaches us is basic human nature society, we tend to model the behavior of "leaders" in our social groups. So, maybe, instead of focusing on the behavior we focus on addressing the causes of such (what I learned in addiction studies.)

Now, I have explained to you in the most professional manner what has transpired here. So, I hope you consider these facts, and the wide reaching implications of such behavior from moderators/staff that I have sought to address with you with precise examples seen in the aforementioned interactions. The rest of the group members of BL are affected by his and other staff/moderators behavior much more so than my own and that is a big deal on forums such as these where such can lead to bad publicity which in turn affects the executive members of the organization in turn (such as Monica herself. Maybe talk to her about what I have so graciously explained to you.)

Anyway, thanks for not closing the thread as I also feel it contains invaluable insights into this highly contested standpoint that @Pissed_and_messed holds which I explained to him as best I could without getting too annoyed with his belligerence toward me, a newcomer to these forums (well, I have actually been here for 15 ish years, and so I do hold valuable insights that I gained here back when these forums were much younger... but whatever lol) His standpoint is also valid mind you, but his attitude is a bit abrassive which is just how he is in general (as are other staff members) so I have come to learn most recently. I accept others for who they are though, so I am not upset nor should the senior staff be considering these staff/moderators were selected in a more authoritative manner rather than voted in democratically. These are the pitfalls of autocratic selection over democracy which we currently see in so many countries of the world right now which are failing their respective citizens as governments. BL simply matches that energy only with more freedom of speech which is respectable in its own right, so meh haha

 

[toe]

Oh. You know that is interesting that you say this because in Uni communications class I was taught to match the tone and inflection of my audience, that this is the most effective means of communicating

Your audience is the entire English-speaking internet.