• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ
  • PD Moderators: Esperighanto | JackARoe | Cheshire_Kat

snorting mescaline

<SpaceHead>

<SpaceHead>

Bluelighter
Joined
Jan 22, 2009
Messages
227
Since Mescaline is such a rare substance to obtain in its pure synthetic form, I was wondering if snorting mescaline would make the dosage about twice as strong like the 2C drugs. I looked this up on the search engine and found one thread that didn't offer much of an answer. I'm assuming that snorting 100mg of mescaline would feel (in your nose) like snorting 100mg of 2C-E, which would burn like all fucking hell so, it would really have to be worth it. Any thoughts? I was also wondering about snorting mescaline on an MAOI, I know this would be going into some unknown territory, but such a rare chem must be conserved! Although, one wouldn't want to ruin the authenticity of the experience of such a classic chemical.
 
Correct me if I'm wrong, but I think taking an MAOI and snorting Mescaline would be rather pointless.
 
Snorting doesn't hurt as much as the 2cs.

I'd go with the MAOi. You can reduce your mescaline dose down to about 1/3 or 3/4s of what you want.
 
I think by "rare" you mean "non-existent". If someone offers you a white powder and tells you it's "mescaline" it isn't, it's a research chemical.
 
I thought MAOIs were only effective with oral dosing, that being the reason one can snort or plug (lol) DMT without an MAOI.
 
Feste said:
Snorting doesn't hurt as much as the 2cs.

I'd go with the MAOi. You can reduce your mescaline dose down to about 1/3 or 3/4s of what you want.
Click to expand...

but then it wont be a real mescaline experience. The maoi will add effects of its own, coloring the experience and making it diferent than mescaline would be on its own.

It is a good way to stretch the mesc though.

Now im also curious about snorting Mesc since SpaceHed brought it up.
 
I don't see how, it only slows the degradation of mescaline into other compounds.

Taking an maoi slows the rate of psilocybin being broken down and also extends the trip and makes it more intense.
 
Bob Loblaw said:
I thought MAOIs were only effective with oral dosing, that being the reason one can snort or plug (lol) DMT without an MAOI.
Click to expand...

An MAOI will still potentiate and increase the duration of substances like mescaline to a certain degree. You can plug or smoke DMT without an MAOI because drugs are only subject to first pass metabolism when you eat them.
Btw I don't think people should be messing around with MAOIs to begin with. Mescaline has a very nice duration already IMO and you're probably going to get sick whether you take and MAOI or not(in fact an MAOI may even cause more nausea). I also don't think snorting mescaline is the way to go :\
 
^No, it only inhibits the enzymes responsible for breaking down simple amines(like the ones in ayahausca) during the first pass effect.
Certain amines, like psilocin for example, cross the BBB before being metabolised and thus no MAOI is needed and it can be taken orally.
 
mixing MAOIs with pure mescaline is seemingly quite safe and has been done numerous times. i seriously doubt moclobemide will add nausea or color the experience significantly, it is a highly transparent drug. there is a small chance it could make the trip slightly more euphoric though, be warned. betacarbolines on the other hand would color the experience significantly and i would not recommend them outside of ayahuasca. my main question is how the duration would be effected, make sure to take note!

take a dose of moclobemide which FULLY inhibits MAO-B (375mg+) and snorting will not be necessary, start with no more than 100mg and perhaps as low as 50mg, you can always supplement. i will be very curious about the results!
 
Ismene said:
I think by "rare" you mean "non-existent". If someone offers you a white powder and tells you it's "mescaline" it isn't, it's a research chemical.
Click to expand...

Actually there was some synthetic mescaline available for a while, don't know if it still is. And extracted mescaline is not impossible. Granted, if someone offers you some for sale, it's almost surely not going to be mescaline, but a lot of people get their drugs by means other than drug dealers. I don't think the OP was talking about being offered a white powder claimed to be mescaline.
 
hamhurricane said:
mixing MAOIs with pure mescaline is seemingly quite safe and has been done numerous times. i seriously doubt moclobemide will add nausea or color the experience significantly, it is a highly transparent drug. there is a small chance it could make the trip slightly more euphoric though, be warned. betacarbolines on the other hand would color the experience significantly and i would not recommend them outside of ayahuasca. my main question is how the duration would be effected, make sure to take note!

take a dose of moclobemide which FULLY inhibits MAO-B (375mg+) and snorting will not be necessary, start with no more than 100mg and perhaps as low as 50mg, you can always supplement. i will be very curious about the results!
Click to expand...

The reason that this is safe is that mescaline is NOT a substrate for MAO. Take a look at this paper:

THE EFFECTS OF RING-METHYOXYL GROUPS ON BIOLOGICAL DEAMINATION OF PHENETHYLAMINES. CLARK LC Jr, BENINGTON F, MORIN RD. J Med Chem. 1965 May;8:353-5.

They made all of the dimethoxy and trimethoxyphenethylamines, and looked at them as MAO substrates. All of them are deaminated except the 3,4,5 (mescaline) and 2,4,6-trimethoxy isomers. Mescaline is a substrate for a different enzyme called serum amine oxidase or semicarbazide-sensitive amine oxidase (SSAO). SSAO is not inhibited by MAO inhibitors. Harmaline does potentiate mescaline, not because of MAO inhibition, but more likely due to its own central effects.
 
Mescaline is metabolsed by MAO-b enyzymes; haramala alks mainly inhbit MAO-a.

Also- there is MAO enyzmes in the bran.
 
I think taking an MAOI with mescaline is borderline retarded. You are risking a hypertensive crisis just to get more effect from a drug. Who would do that? Do you want to risk popping blood vessels in your head to get high? Fuck no, you don't.

And FWIW, at one time when I had decent amounts of mescaline sulfate on hand I did try insufflating it for the reasons you mentioned. I would no do this again. The amounts required are still so large as to make it unpleasant (think about a major coke binge [if you've been there] compressed into a small time frame), the drip is continuous and awful, and the dosage for worthwhile effects was not reduced that much.

In short:
It is not that hard to obtain if willing to put in the time and effort, and beyond that, please do not waste it like this. I've taken synthetic, stuff extracted from plants and purified via chromatography, crude extracts from plants, and raw plant material in the form of peyote and Trichocereous species. I would not recommend this at all.
 
Delsyd said:
maybe true for alot of people but not everyone.

Why would we assume everyone has an RC instead of actual mesc?
Click to expand...

Because I've heard lots of people claim someone has sold them "synthetic mescaline" or "mescaline pills". It's one of the most popular cons on the psychedelic drug scene. It's always a research chemical. You tell someone it's "synthetic mescaline" so they pay you more money.
 
You must log in or register to reply here.
Top