Tryptamines Shrooms v Antidepressant

[foodcrisis]

What do you mean by withdrawal
Like heroin withdrawal?
If so I’m not even going there

ime after like an hour two of not using coke, i just feel generally tired and shitty/restless and want more coke... my friend stopped by and offered me a line while i was tripping, so i didn't have any more.... i wouldn't say it's as bad as what people describe as intense heroin withdrawl at all.. i just generally dont feel 100%.

i wouldn't really do coke while tripping cause a person might not really realize how much they are consuming and that could become a problem... if i were to try the combo, i'd probably only keep a certain amount i was used to using around me, like i wouldn't trip while sitting on a big stash of anything a person could overdose on... some people might be able to control themselves, but i'd just be weary of the situation. a kid from my town supposedly OD'd on heroin while tripping cause he forgot what he was doing. seems like something that happens.

 

[Misterx1976]

Like, if you feel cranky without weed or something, or if weed fixes any mirtazapine withdrawal you could be experiencing.

That makes sense thank you

 

[Pissed_and_messed]

If I get back to those half-lives; fentanyl half-life is very low in theory, but people who are hopelessly addicted to it and take big doses for long time, can get precapacitated withdrawal from bupe even week after quitting. Because at some point half-life starts to stretch and fentanyl starts to bond to tissues. There are reports of that in bluelight too. So predicting things from half-lives is always kindofa, yea, you have to start somewhere, but it does not take you to your destination.

 

[iom]

Many people who take anti-depressants including mirtazapine experience serious adverse effects upon quitting cold turkey or tapering too rapidly. It depends a lot on the person, the dose taken, and duration of use. If these adverse effects occur, it may be difficult to reverse them even by resuming the drug at the original dosage.

I feel bad having to say this, because mirtazapine most certainly does block the effects of psychedelics, and a safe taper will require months if not years. If you are serious about tapering or discontinuing the mirtazapine and wish to do it as safely as possible, then I highly recommend researching the subject on Surviving Antidepressants.

Best wishes.

 

[Pissed_and_messed]

I have never taken mirtazapine for longer than 6 weeks consecutively, but what I have gathered reading is, that some people do not develop that bad withdrawal syndrome. And unlike some other psychiatric medications, it seems that prognosis is relatively good; you should be fine eventually, it just takes time.

 

[Misterx1976]

Many people who take anti-depressants including mirtazapine experience serious adverse effects upon quitting cold turkey or tapering too rapidly. It depends a lot on the person, the dose taken, and duration of use. If these adverse effects occur, it may be difficult to reverse them even by resuming the drug at the original dosage.

I feel bad having to say this, because mirtazapine most certainly does block the effects of psychedelics, and a safe taper will require months if not years. If you are serious about tapering or discontinuing the mirtazapine and wish to do it as safely as possible, then I highly recommend researching the subject on Surviving Antidepressants.

Best wishes.

Well I’ve gone from 30mg down to 22.5mg already in 3 days and feel ok
The next three days down to 15mg
If at any point I feel poorly I’ll go straight bank up gradually and try the penis envy anyway and see if I get any reaction
I only have 2g of it anyway and a DMT vape I want to try but thanks for the advice

 

[Pissed_and_messed]

I was still having some BZD wds when I quit that six weeks 30 mg/day regimen so it is hard to distinguish details. But the most overwhelming symptom I experienced was the insane physical restlessness and insomnia. I did fast low-dose taper and it got better quickly.

 

[red22]

Unfortunately mirtazipine is an atypical antidepressant and acts more like an antipsychotic by acting as a 5HT2a antagonist.

That’s a sharp observation — and you're right to raise an eyebrow. But let’s unpack it:

SERT is the serotonin transporter, responsible for reabsorbing serotonin back into presynaptic neurons. SSRIs and SNRIs block SERT to increase serotonin levels, which is generally associated with antidepressant effects.

Now, here’s the twist with mirtazapine:

Mirtazapine does not block SERT at all.

Instead, it increases serotonin indirectly by blocking presynaptic alpha-2 adrenergic receptors (which are inhibitory). This disinhibition leads to increased release of both norepinephrine and serotonin.

Then, it selectively blocks certain serotonin receptors (5-HT2A, 5-HT2C, 5-HT3) — so the extra serotonin that’s released preferentially acts on 5-HT1A, the receptor most associated with antidepressant and anxiolytic effects.


So, while it might sound paradoxical — blocking serotonin receptors = more antidepressant effect? — mirtazapine actually enhances the “good” serotonin signaling (5-HT1A) and suppresses the ones linked to anxiety, insomnia, or nausea (5-HT2A/C and 5-HT3).

In a way, it’s a “fine-tuner” of serotonin rather than a blunt SERT booster like SSRIs. (ChatGPT)

 

[Misterx1976]

That’s a sharp observation — and you're right to raise an eyebrow. But let’s unpack it:

SERT is the serotonin transporter, responsible for reabsorbing serotonin back into presynaptic neurons. SSRIs and SNRIs block SERT to increase serotonin levels, which is generally associated with antidepressant effects.

Now, here’s the twist with mirtazapine:

Mirtazapine does not block SERT at all.

Instead, it increases serotonin indirectly by blocking presynaptic alpha-2 adrenergic receptors (which are inhibitory). This disinhibition leads to increased release of both norepinephrine and serotonin.

Then, it selectively blocks certain serotonin receptors (5-HT2A, 5-HT2C, 5-HT3) — so the extra serotonin that’s released preferentially acts on 5-HT1A, the receptor most associated with antidepressant and anxiolytic effects.


So, while it might sound paradoxical — blocking serotonin receptors = more antidepressant effect? — mirtazapine actually enhances the “good” serotonin signaling (5-HT1A) and suppresses the ones linked to anxiety, insomnia, or nausea (5-HT2A/C and 5-HT3).

In a way, it’s a “fine-tuner” of serotonin rather than a blunt SERT booster like SSRIs. (ChatGPT)

So does it block mushroom effects or not?
In layman’s terms

 

[Pissed_and_messed]

yes it does

 

[foodcrisis]

i think they are saying it blocks the effects... anti-psychotics block the effects of psychedelics and one poster is saying that the mirtazapine works in a similar way i guess.... i don't know why you are on this med, sorry if you've already posted, but you may find shrooms helping you with some of the reasons why you are on the meds. i'm not saying you shouldn't get back on them or you should go off them if you aren't already off them, but sometimes shrooms help people with depression. it may be worth evaluating how you feel after trying them and not going back on the med right away... some times low doses of shrooms help people with depression greatly.

if you are looking for a strong trip and don't want to go off meds, maybe look into salvia for a very strong trip... some people hate that stuff, but i'd look into it (read about it as much as possible before doing it cause people get varying results). supposedly no drugs stop the effects of smoking it... there are still some sites selling that stuff... it sounds like you have some mushrooms and dmt in your possession that you want to use though.... i don't think it's really studied though if salvia would really mess with a person's anti-depressants if you are experiencing severe depression... like any psychedelics, i've heard of people going down rabbit holes and becoming insane and even killing themselves with these types of drugs... i just know i hear people can still trip on salvia on all different meds that normal psychedelics wouldn't work with.

 

[Pissed_and_messed]

mirtazapine has nothing to do with dopamine receptors and many others considered important for antipsychotic and is better described as powerful knock-outter and anti-anxiety med which sometimes helps with depression and even gastrointestinal issues. Upon habituation to antihistamine effects it can also turn out inducing minor, benign mania. (not clinical mania commonly)

but yeah it also antagonizes few serotonin receptors.

 

[Misterx1976]

i think they are saying it blocks the effects... anti-psychotics block the effects of psychedelics and one poster is saying that the mirtazapine works in a similar way i guess.... i don't know why you are on this med, sorry if you've already posted, but you may find shrooms helping you with some of the reasons why you are on the meds. i'm not saying you shouldn't get back on them or you should go off them if you aren't already off them, but sometimes shrooms help people with depression. it may be worth evaluating how you feel after trying them and not going back on the med right away... some times low doses of shrooms help people with depression greatly.

if you are looking for a strong trip and don't want to go off meds, maybe look into salvia for a very strong trip... some people hate that stuff, but i'd look into it (read about it as much as possible before doing it cause people get varying results). supposedly no drugs stop the effects of smoking it... there are still some sites selling that stuff... it sounds like you have some mushrooms and dmt in your possession that you want to use though.... i don't think it's really studied though if salvia would really mess with a person's anti-depressants if you are experiencing severe depression... like any psychedelics, i've heard of people going down rabbit holes and becoming insane and even killing themselves with these types of drugs... i just know i hear people can still trip on salvia on all different meds that normal psychedelics wouldn't work with.

Thank you very much for that
I have found my depression episodes to be fleeting for a long time
That’s why I’m trying to come off the meds to give myself the old college try but at the same time I want to try mushrooms and DMT so will do next week if I get off the meds over the next 10 days

Thanks again

 

[foodcrisis]

Unfortunately mirtazipine is an atypical antidepressant and acts more like an antipsychotic by acting as a 5HT2a antagonist.

mirtazapine has nothing to do with dopamine receptors and many others considered important for antipsychotic and is better described as powerful knock-outter and anti-anxiety med which sometimes helps with depression and even gastrointestinal issues. Upon habituation to antihistamine effects it can also turn out inducing minor, benign mania. (not clinical mania commonly)

but yeah it also antagonizes few serotonin receptors.

this is just where i got the info it was similar to anti-psychotics...

for me i feel like they are both similar cause they'd kill my sex drive and that's one of the main things i notice when the drugs initial side effects wear off after getting used to any of the drugs.. lol... i've never actually tried mirtazapine, but i've used anti-depressants and anti-psychotics... idk about them.. supposedly both classes of drugs help some people... i'd look into trying to cure depression with dosing shrooms occasionally though. if it doesn't work, you can always go back on the meds if they are helping now.... if they were really working great, i'd assume they wouldn't be looking into shrooms or dmt, but who knows, some people just get bored.

 

[Pissed_and_messed]

I wonder if it could help alleviate psychosis symptoms tho, it is not really designed for that but maybe some qualities could have some marginal benefit. Sleep is never bad with psychosis at least haha.

 

[JackARoe]

mirtazapine

Does it help with depression though? How glad I never got sent to a psychologist or doctor. I would have been labeled with every ABC ailment. Depression, ADHD, Bipolar too probably. Then I would hear from some recent grad with zero experience tell me I am on some spectrum. No thanks. I'd rather not know. Too late anyway, I lived my life like that, not caring to have a psych, who himself has a million problems, label me and give me meds that interfere with my favorite sacraments. All the while their own home life is in shambles themselves. Some of the treatments used in the past have killed people. Electroshock. places like Lexington, and labotomies. But now we have pills that can break things faster. I think back to the Jazz musicians that got sent to Lexington and came out completely screwed up. All because they took a drug that felt good and logically continued. Yeah that needs a labotomy. I think the person that thought that up needs one not the patient.

OP you let us know if you indulge and how it goes.

 

[foodcrisis]

I wonder if it could help alleviate psychosis symptoms tho, it is not really designed for that but maybe some qualities could have some marginal benefit. Sleep is never bad with psychosis at least haha.

my doctors might want to put me on something like that cause i always complain about anxiety... i'm not really into the idea... they aren't pushing me to take AP's, but i do take a very small dose to make my parents happy at this point, and might continue to do so so they don't take away my disablity payments. i have to see if my back MRI's will cover my ability to not work....

i don't know about going into psychosis, but i read mirtazapine helps with anxiety. for me, the voices i get kind of come when i'm anxious or down, or when i'm super abnormally happy like taking lsd or something... so i could see a med like this kind of helping with some people's schizophrenia.. SNRI's aren't really for people with schizophrenia, but mirtazapine isn't an SSRI or SNRI... different people get different results from meds, so i'm gonna say if it helps people get on a sleep schedule and limits anxiety it's going to help some people.

i'm googling and they prescribe mirtazapine along with AP's for schizophrenia. makes sense... as a schizophrenic person, i find my brain chemistry feels all over the place... i'm always saying to my doctors that i want to get manic depression and anxiety disorder added to my diagnosis so i have a better chance of staying on disablity payments, but they say that stuff kind of just goes along with schizophrenia... idk. i definitely hear of people diagnosed with multiple things.

 

[Pissed_and_messed]

some say so, some are not impressed of it regarding its worth as antidepressant.

I found that it gives this nice natural feeling lifted careless buzz on large doses after I have habituated to antihistamine effects, like, it doesn't get you outright high but I could tell it is "working". But ehhh eventually it started to make me feel rather indifferent, things felt boring even if I could not complain feeling terrible or anything and I have not taken it sporadically for ages anymore, only like once a week. And oh god the cognitive side-effects and amnesia argh...

I have not really gone balls deep into all these psychiatric medications, but I have it on prescription still because many of its claimed qualities were like exactly what I need, including even some physical effects, and it eventually proved to be valuable! I am not interested on any other but this is some good shit occasionally haha.

 

[Robi]

my doctors might want to put me on something like that cause i always complain about anxiety... i'm not really into the idea... they aren't pushing me to take AP's, but i do take a very small dose to make my parents happy at this point, and might continue to do so so they don't take away my disablity payments. i have to see if my back MRI's will cover my ability to not work....

i don't know about going into psychosis, but i read mirtazapine helps with anxiety. for me, the voices i get kind of come when i'm anxious or down, or when i'm super abnormally happy like taking lsd or something... so i could see a med like this kind of helping with some people's schizophrenia.. SNRI's aren't really for people with schizophrenia, but mirtazapine isn't an SSRI or SNRI... different people get different results from meds, so i'm gonna say if it helps people get on a sleep schedule and limits anxiety it's going to help some people.

i'm googling and they prescribe mirtazapine along with AP's for schizophrenia. makes sense... as a schizophrenic person, i find my brain chemistry feels all over the place... i'm always saying to my doctors that i want to get manic depression and anxiety disorder added to my diagnosis so i have a better chance of staying on disablity payments, but they say that stuff kind of just goes along with schizophrenia... idk. i definitely hear of people diagnosed with multiple things.

Mirtazipine was so easy to get on and getting off,I take shrooms 4 times a year and now they feel better in my experience, I was prescribed it for sleep and appetite increase,I couldn't eat or sleep.Many said it was worthless but sure helped me

 

[Quasimoto]

Marketed antipsychotics are both serotonin and dopamine antagonists, because there are 2 prevalent theories involving psychosis and schizophrenia; the serotonin hypothesis and dopamine hypothesis.

Mirtazapine only effecting serotonin means it wouldn't be used as a mainline therapy, only adjunctly.