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Tryptamines Shrooms v Antidepressant

Misterx1976

Misterx1976

Bluelighter
Joined
Feb 9, 2016
Messages
208
Hey guys just some general information if anyone can help
I’m trying my first mushroom trip next week going to try 0.5 for my first time or mate 1g
I’m currently on mitrazipine anti depressants 30mg
What I’ve read is that the shrooms won’t work with these so I need to taper off
I’m going 3 days 22.5mg
3days 15mg
3days 7.5 mg
Then after 2 days try 0.5mg of dried penis envy
Can anyone say if I’m doing this right and if it’s true that mitrazipine blocks the effects

Thank you
 
Unfortunately mirtazipine is an atypical antidepressant and acts more like an antipsychotic by acting as a 5HT2a antagonist. This is the same receptor mushrooms bind to. It will significantly blunt or even completely block the psychedelic effect. You might just feel a bit of stimulation.

You will have to flush it out of your system to get the full effect, which will take a couple weeks, and may be unadvisable per whatever you take it for.
 
I admit that if on regular regimen, 5 half-lives might not be enough because there is so much drug in system, but I claim that one week might be also enough, if lucky. But I would also wait for 2 weeks if there is not much of material. Mirtazapine is metabolized faster in men BTW.

But as you have stated in another thread, apparently 5ht2a-antagonism might downregulate 5ht2a, so, it might be also person has cleared system, but is still not getting full effects.

0,5 g penis envy is probably good dose.
 
Pissed_and_messed said:
I admit that if on regular regimen, 5 half-lives might not be enough because there is so much drug in system, but I claim that one week might be also enough, if lucky. But I would also wait for 2 weeks if there is not much of material. Mirtazapine is metabolized faster in men BTW.
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The 5 half lives rule goes out the window if a drug has a half life of over 24hr, because this causes the plasma levels to steadily increase over time. If OP takes 30mg per day, has been taking it for years, and metabolizes it slower than 24hr half life, they will have much more than 30mg in their system. Thus requiring many more than 5 half lives for total clearance.

I am not that familiar with mirtazapine pharmacology, though. I assume it is much less potent of an antagonist than typical antipsychotics.
 
Psilocybin & LSD are very effective antidepressants…..in low therapeutic doses

For me, LSD 100ug is a perfect functional dose…….50-75ug also little more gentle for public areas + Alprazolam 1mg (potent anxiolytic & antidepressant)

LSD has dopaminergic properties that Psilocybin doesn’t have, so LSD is slightly more energetic and pro-social ….slightly more euphoric and pleasurable . Damn I Love LSD.

I take 100ug every Sat in summertime enjoying Mother Nature and the great outdoors, cottage country…….GF took me to the Royal Botanical Garden which on LSD was like the garden of eden in Gods Kingdom…..flowing trickling crystal clear steams of water, rock gardens, beautiful flowers everywhere with massive bumble bees landing everywhere, like a national park in Yellowstone or Wyoming, Montana etc …….it was unreal…..like what I’d image heaven to be like. The most peaceful beautiful place on earth ….wow

The most incredible afterglow too with LSD 100ug ……too much could be unpleasant 250ug + etc ……100ug standard safe controllable dose. Can talk to anyone and they wouldn’t know jack

Swimming in a shallow warm clean clear lake at cottage with sun blazing down, blue sky no clouds, few good friends, good music, food, drinks, cottage with washroom, shower, tv, beds, etc ……roaring fire and night time with the stars looking like shimmering diamonds ..woooow…..just unreal the overwhelming beauty of this planet. LSD just makes you truly see it all and appreciate it.
 
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Only if your “Set & Setting” are on point….no negativity or stressors

SSRI’s and antidepressant I heard make you flat….emotionless…..you can’t sit in a dark basement with no social interaction all day and be happy

Ultimate antidepressant……..being active, sunshine, healthy clean diet with lots of water. Lots of walking or exercise releasing natural monoamines & endorphins (bodies natural Amphetamine's and Opiates) and a healthy social circle, friends and family, even 1 good friends can make all the difference. We are social animals that need mental stimulation, emotion and spiritual wellness …..get in touch with Mother Nature …..walking through trails in the summer, biking etc

You’ll notice you’ll be more happy and optimistic, more energy and positive outlook on life…….Prozac won’t give you that

In a medical journal I read study participants 45min-1h of cardiovascular exercise had significant increases in Phenylethylamine metabolites in their urine samples as apposed to controls . Phenylethylamine is our brains natural Amphetamines responsible for the “runners high” . Amphetamines are Alpha Methylated PHenylETylAMINES.


….climate through sexual intercourse (or masterbation lol) flood your CNS with natural endorphins (bodies Morphine) oxytocin & serotonin….and yes, Dopamine

All feel good natural antidepressants with anxiolytic & euphoric properties …robust mood-boosting effects you’ll experience

Stay healthy ….in mind, body & soul.

Peace ✌️
 
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Quasimoto said:
The 5 half lives rule goes out the window if a drug has a half life of over 24hr, because this causes the plasma levels to steadily increase over time. If OP takes 30mg per day, has been taking it for years, and metabolizes it slower than 24hr half life, they will have much more than 30mg in their system. Thus requiring many more than 5 half lives for total clearance.

I am not that familiar with mirtazapine pharmacology, though. I assume it is much less potent of an antagonist than typical antipsychotics.
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it is selective but really strong in all 5ht2x.

And yeah you are probably right after all. I have always felt like it takes more than week to get rid of cognitive side-effects if I've been taking it for few weeks.
 
So to clarify if I do the one week taper and then try 0.5mg penis envy on day 10 will I get any effects?
Thank you for all your kind replies
 
day then completely off? It could be worth a shot. 10 days after jump you could have, in best case, 0.02 % left in system of what you had before you jumped. That is, if you are fast metabolizer and mirtazapine clearing rate does not decrease when blood concentrations rise. Because some compounds satyrate enzymes on high enough concentrations and begin to get absorbed into fat and proteins.

mirtazapines affinity is also so high that even small amounts in system that could be present could hinder trip.
 
shrooms tend to cause tolerance, some don't get so bad but some can tell it does not work as well for 2 weeks some can trip even bit harder few days after on same dose and second psychedelic trip can be stronger than first on same dose with interval between doses because it kinda habituates brains to trip, permanently. My first psychedelic trip with 1 g cubensis and weed I kinda tripped but it was like level that nowadays feels like maybe 0,5 g max. cubensis. Shrooms started to work more powerfully after few trips.

I forgot my point; I would wait at least week after first dose.
 
Pissed_and_messed said:
shrooms tend to cause tolerance, some don't get so bad but some can tell it does not work as well for 2 weeks some can trip even bit harder few days after on same dose and second psychedelic trip can be stronger than first on same dose with interval between doses because it kinda habituates brains to trip, permanently. My first psychedelic trip with 1 g cubensis and weed I kinda tripped but it was like level that nowadays feels like maybe 0,5 g max. cubensis. Shrooms started to work more powerfully after few trips.

I forgot my point; I would wait at least week after first dose.
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I’ve been told not to smoke weed during taking shrooms
Do you think it’s doable
I was going to take the day off weed
 
aaaaaahhhhh this is really individual thing and even I recognize that there are clear plus and cons to weed during trip even if you are kindofa person that likes weed.

I use to take low to moderate dose edible just before the trip, I don't want to experience comeup same time with psychedelic comeup, and I start vaporizing in the comedown. I don't commonly smoke on trip except in some situations, because I feel like smoking with tobacco causes more anxiety in comeup because of nicotine.

Generally I think you should avoid all kind of withdrawals during trip if possible, so I think you could consider very low dose of weed. But definitely be careful, weed knocks the trip into very deep waters. Use your common sense. I think there is no one size fits all protocol regarding weed and shrooms.
 
Pissed_and_messed said:
aaaaaahhhhh this is really individual thing and even I recognize that there are clear plus and cons to weed during trip even if you are kindofa person that likes weed.

I use to take low to moderate dose edible just before the trip, I don't want to experience comeup same time with psychedelic comeup, and I start vaporizing in the comedown. I don't commonly smoke on trip except in some situations, because I feel like smoking with tobacco causes more anxiety in comeup because of nicotine.

Generally I think you should avoid all kind of withdrawals during trip if possible, so I think you could consider very low dose of weed. But definitely be careful, weed knocks the trip into very deep waters. Use your common sense. I think there is no one size fits all protocol regarding weed and shrooms.
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Which is a better trip killer

Benzos or Cocaine?

I’ve head they are a good nuclear option to a bad trip
 
if a person really loves weed and never has bad experiences, i'm gonna say they are probably gonna be okay with it on low doses of shrooms, but you never really know i guess. it could cause a person to panic, but that can happen with out weed. really depends on the person.

like one hit of good weed is enough to stop some of the weird feelings of a shroom trip imo... i like to smoke on it, however for years, i used to use shrooms to take a day off smoking... i always love the experience smoking weed though. shrooms is kind of unenjoyable with out weed ime, but i do it anyways..

if you smoke while tripping expect it to be it's own unique experience and not 100% the same as the buzz a person would normally get... on a low dose of shrooms though, i don't think it's going to cause ego loss or anything.. when i smoke on lsd some pretty crazy stuff happens.
 
Misterx1976 said:
Which is a better trip killer

Benzos or Cocaine?

I’ve head they are a good nuclear option to a bad trip
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i've never heard of cocaine as a trip killer... a lot of people swear by benzos... however shroom trips really aren't that long, so if i'm having a bad time, i always just wait it out and usually i start to feel better and/or the drug wears off pretty quickly.

i did coke at the beginning of a 2ci or 2cb trip, i forget which one it was, but after like an hour, i was withdrawing and it was a terrible time for the rest of the trip. the coke didn't really dull the trip that i was aware of, just made me feel bad eventually.
 
foodcrisis said:
i've never heard of cocaine as a trip killer... a lot of people swear by benzos... however shroom trips really aren't that long, so if i'm having a bad time, i always just wait it out and usually i start to feel better and/or the drug wears off pretty quickly.

i did coke at the beginning of a 2ci or 2cb trip, i forget which one it was, but after like an hour, i was withdrawing and it was a terrible time for the rest of the trip. the coke didn't really dull the trip that i was aware of, just made me feel bad eventually.
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What do you mean by withdrawal
Like heroin withdrawal?
If so I’m not even going there
 
cocaine stops molly from working because it is stronger in same biological targets but causing different response.

Stimulants on psychedelics kinda like okay you know stimulans tend to make you feel less sensitive and kinda impervious, so there is that. But you should opt for benzos if you don't know what you are doing, you should try like lsd+some stimulant separately when you are having good time, because it can cause all the wrong reactions too and you should be ready to deal with that already.

shrooms is kinda antithetical to stimulants anyway. I don't mean that lsd+stim would be particularly interesting combo either but it might be worth trying if you are bored or something.
 
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