Severe vasoconstriction with 5-MeO-MiPT

[Survived Abortion]

I want to warn people about a potential danger with 5-MeO-MiPT: vasoconstriction. A recent experience with the chemical has led me to believe that the physical side-effects may be quite underestimated.

I have used this substance a few times now. All of those experiences have been relatively free of any body-load - except this most recent one. After roughly six hours from my first dose, and maybe an hour after a second re-dose, I noticed some severe physical discomfort. I had been laying under a tree for an hour or so, and it had gotten dark whilst I was staring off in to it's blossoms. When I attempted to stand up, I was confronted with sudden pain in my legs. Specifically, it felt like the veins running from my ankles up to my thighs were solid, and it felt like something in there was going to burst.

The two main issues with this physical problem were:

• This pain could only be relieved by staying active on my feet; resting by sitting or laying down for a moment would mean intense pain and discomfort upon standing again. (This is due to the vascular pumping action of the muscles when standing and in activity).
  
• The pain continued for 48 hours, diminishing over time.

[The trip itself was incredible; a very much needed ego-dissolver, one that brought about another teaching of the lesson that I keep forgetting, the thing that I keep needing to learn again and again. It enabled me to perceive Gaia-Sophia in untold beauty, liberated from the cunning arrogances of "normal" every-day consciousness. It brought me in proximity of the 'singularity'.]

This was at a dose I believed to be 30mg (I consumed some capsules which I had made up earlier in the year and carried around in my bag, and ate them whilst out catching some rays. I had forgotten the dose, but I was pretty sure of the safety margin).

If anyone else has experienced similar issues with vasoconstriction with 5-MeO-MiPT, please share.

 

[PippUK]

I think perhaps your dosage is on the high side. I sampled a half gram batch over the space of two years, sharing some and never personally used over 15mgs at during any one sitting.
If you are looking for some kind of therapeutic realisations, I would recomend 4sub trypts as a more practical tool for such purposes. I found that 5MeO-MIPT/DIPT as more recreational from a physical perspective and as usefull adjuncts to sex, dancing etc, although the mental effects were often profound as well. But in my experience, this kind of inspiration was adequately provided at 10-15mgs.
Most of the 5MeOs I've tried had more profound physiological effects in comparrison with their 4sub equivalents.
Having said that, I do not recall reading other instances of the kind of symptoms you describe, although there are quite a few overdose reports including serious toxicity in cases of extreme dosage.
I sometimes get peculiar vascular changes in my limbs on several different psychedelic materials, but most profoundly with 5sub tryptamines. This is why I tend towards 4subs when I want to go into reasonably deep personal states of thought or realisation. Your proximity to the 'singularity' can seem pretty damn close with these materials if you want to look at it like that.
That is not to say that 5MeOs have no merit on that level. There are plenty of really good 5MeO-DMT reports vouching for that.
I think you are pushing your doses higher on the wrong material. 5MeO-MIPT has some nice features, but they are not what you are maxing out on when you take 30mgs. You are safer pushing up gradually with a more forgiving material. I would certainly step back from your sample of 5MeO-MIPT for a little while, and maybe try a different angle when you feel ready.
I hope you are doing OK and that your symptoms are gone.
Peace - Pipp

 

[✰hyperobjects✰]

0_0 30 MGS?! w0wzers dude. That's a lot. I found Moxy quite magical and healing, my sweet spot with it is 7mgs. 15 mgs of 5-meo-mipt one time at a club provided wayyy too much overstimulation for me, I can't imagine 30 would be like. Next time you might want to try a smaller dose. You could have nicely dosed you and two other mates with 30mgs.

 

[amanitadine]

Pipp said it perfectly.

Cheers

 

[allium]

Thank you for the report! I will definitely go higher gradually, and I won't jump from 12 mg(my maximum dose) to 30 mg.

 

[DwayneHoover]

I had good luck with doses in the range of 18-22mg, never felt anything bad. Initial body buzz, often erotic, with some shimmery visual effects, turning more deeply psychedelic at 3-5 hours in. Nice.

 

[kingme]

that 30mg is a hell of a dose. personallyive never gone above 10mg with this substance, and even that only once. i just find lower doses very nice and feel that more is not needed, nor pleasurable. lately ive grown a bit sensitive to 5meo mipts body load, but at such low doses have never experienced actual pain like the OP

 

[Survived Abortion]

Words of wisdom Pipp, thankyou indeed.

The 4-subbed tryptamines psilocin, miprocin, iprocin, and metocin have all been very easy on the body in this respect. However, I touched upon an aspect of the experience which I'm not sure I could reach qualitatively with a 4-sub. 5-MeOs have a unique way of presenting things. That's not to say that I don't find the -ocin family of psychedelics useful - I think they're incredible in their very own way.


And thanks for the feedback, keep it rolling in. The vascular aspect was so hardcore that it seriously made me re-think my use of synthetics at the time, although I'm not feeling that way now. The experience is so valuable, I would never like to say never. But I would not want anyone to suffer physiological consequences if they can be prevented by a sensible dosing strategy.

I am tempted to do an upwards dose titration in the summer, to find an optimum dose, rather than shooting in the dark and praying for mercy, like I have hitherto been doing.

 

[Survived Abortion]

I just thought I'd give an update on this:

I am still experiencing occasional vascular spasms. I had one in the shower yesterday morning; it was in my right leg and was of mild-moderate intensity. The duration was a few seconds, maybe ten, and was followed a few minutes later by another less severe spasm in the same venous network.

This isn't completely suprising, since I have been aware of a semi-constant vasoconstrictive action inside my brain/skull following the experience. It feels almost ergoline in that respect, with a sensation of fluctuation in the blood vessels that are responsible for migraines. I have also had a few 'rushes' of the tryptamine sensation which accompanied the initial experience, usually lasting for thirty seconds to a minute and accompanied by visuals of mild-moderate intensity. These 'rushes' are most evident upon physical exertion.

I am mentioning this because it would seem that 5-TH2a mediated vasoconstriction can last a considerably long time after the initial dose, even after the drug has been completely metabolized. The dose which precipitated this was taken on Bicycle day, April 19th. The date is now April 28th.

I actually enjoy the trippy rushes - they are like an excessive form of HPPD where you get to be back in the trip for a few moments.