Misc Serotonin Releasing drugs

[MagickalKat777]

Yeah I actually really enjoyed MDAI. I and a number of others think that the people who disliked it didn't actually get MDAI. There is so much fake MDAI out there.

Its a shame really. It is a fantastic chemical!

 

[MrSpeedyG]

I think there is actually a study done somewhere that mixing MDAI with amphetamine will actually result in dopamine induced serotonergic neuroxtoxicity... which sucks!

EDIT: Here it is Serotonin neurotoxicity in rats after combined treatment with a dopaminergic agent followed by a nonneurotoxic 3,4-methylenedioxymethamphetamine (MDMA) analogue

 

[MagickalKat777]

Its not surprising to me at all though to be honest. Doesn't MDAI have a stronger SERT affinity than MDMA?

EDIT: Wait, its higher than MDA but not higher than MDMA if I remember correctly.

 

[MrSpeedyG]

Just adds to proof of MDMA toxicity theory being due to dopamine autooxidation in serotonin neurons

 

[mork]

yup, meth at high doses with cause serotonin release

 

[mork]

Just adds to proof of MDMA toxicity theory being due to dopamine autooxidation in serotonin neurons

really? I ask that in a genuine way - does the MDMA molecule fit in the dopamine receptor?

 

[MrSpeedyG]

really? I ask that in a genuine way - does the MDMA molecule fit in the dopamine receptor?

MDMA releases not only just serotonin, but also dopamine and norepinephrine albeit to a much lesser extent however they are an integral part of the MDMA high. The theory is that simultaneous serotonin and dopamine release results in serotonergic neurotoxicity not just dopaminergic toxicity. It is said that excess dopamine makes it into the serotonergic pathways and is able to be taken up by the serotonin transporter (all monoamine transports are capable of transporting not their labelled monoamine but also others) and auto-oxidises within the neuron causing damage to it via hydroxy and IIRC superoxide radicals AKA oxidative stress.

This is why mixing MDMA with meth for example will greatly increase neurotoxicity that either alone.l

 

[TCMVegas]

check out MDAI:

http://en.wikipedia.org/wiki/MDAI

Selective Serotonin Releasing Agent

non-neurotoxic

interesting effects

 

[Rybee]

Doesn't actually release Seretonin but Tramadol is a Seretonin Reuptake Inhibitor to some extent.

 

[pcplease]

I thought Tramadol was a noticeable Selective Norepinephrine Reuptake Inhibitor (SNRI), but I could be wrong.

It's been mentioned, but methylone WAS designed to be a non-neurotoxic Serotonin Releaser.

 

[~QuirKyNai~]

Significant serotonin releasers are AMT, MDMA, MDA, 4-MMC, Methylone off the top of my head.

Most psychedelics work by agonism of serotonin sites (5ht2a being a major one), not through serotonin release.

I'm sure there are a number of stimulants that have a minor releasing function but not as a primary function of their action.

Does methylone or Ethylone release dopamine as well??

 

[MagickalKat777]

Does methylone or Ethylone release dopamine as well??

Methylone actually has the same dopamine properties that MDMA does. Its far more dopaminergic than serotonergic (I believe there's a 3 fold decrease in serotonergic action compared to MDMA if I remember correctly - I know its quite high).

Ethylone, I'm not sure about. There hasn't been much research on that one.

 

[Stotched]

I thought DXM is actually a serotonin releaser aswell...Hmm. But it's effects on serotonin, wether realeaser or just reuptake inhibitor do not account for it's overall recreational effects as it isn't that potent.

Weed does not affect serotonin or dopamine either.

Methylone is a serotonin releaser.

Meth is also a serotonin releaser, although even less than methylone.

Weed definitely affects serotonin and dopamine. It also affects mu, kappa, and delta opioid receptors. It obviously doesn't agonise them, or there would be severe withdrawals upon stopping, but I'm thinking it's more of a positive allosteric modulator, but scientific studies have shown again and again that weed affects serotonin, dopamine, and opioid receptors.

 

[f33lg00d]

Weed definitely affects serotonin and dopamine. It also affects mu, kappa, and delta opioid receptors. It obviously doesn't agonise them, or there would be severe withdrawals upon stopping, but I'm thinking it's more of a positive allosteric modulator, but scientific studies have shown again and again that weed affects serotonin, dopamine, and opioid receptors.

Throw me a source for weed affecting endorphin levels. Very interested.

 

[Stotched]

http://proxychi.baremetal.com/cannabiscoalition.ca/info/CichewiczCBOpioisSynergyLifeSci2004.pdf

In addition, studieshave determined that the analgesic effect of THC is, at least in part, mediated through delta and kappa opioid
receptors, indicating an intimate connection between cannabinoid and opioid signaling pathways in the modulation
of pain perception

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1575338/

This article has multiple points that say THC concentration in the body are lessened significantly by naloxone.

http://www.jneurosci.org/content/21/14/5344.full

http://en.wikipedia.org/wiki/Δ-opioid_receptor#Agonists

Even wikipedia has THC, and CBD listed as delta opioid agonists.

 

[Jabberwocky]

http://www.ncbi.nlm.nih.gov/pubmed/15217374

THC is a strong beta endorphin releaser, extract:

Together these results indicate that certain psychotropic effects of THC related to drug abuse liability are regulated by THC-induced elevations in extracellular beta-endorphin levels in brain areas involved in opiate reward and reinforcement processes.

another study implicating the role of THC's pain reducing effects and opiate inducing effects - based on delta/kappa receptors.

i noticed a tolerance increase to opiates when i smoked cannabis while taking then (oxycontin, dihydrocodeine, morphine, hydromorphone) and resulted in more euphoria being produced.

i know this is veering off track on serotonin though, but the cannabinoids themselves released produce endorphin release - CB receptors are in the brain for a reason.