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serotin syndrome, doubled by MDMA and bottle water

deaf eye

deaf eye

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was watching some documentary about bottled water, they said there are chemicals in the plastic bottle that leach into the water, this one chem they mentioned is neuro toxic and caused serotonin syndrome ,

so when i heard that got me thinking if your dumping pills, and drinking lots of bottled water to stay hydrated, thinking you are doing the healthy thing,

you may be doubling up with neurotoxins


i dont know for sure, just a theory that popped in my head that seems to make some sense in my warped noodle

be safe
 
It’s reported that several chemicals can leach from plastic and into the water - I do think that the chances of dehydrating by not drinking when raving is greater than you catching SS from drinking a few bottles of water though.
 
yea i agree, the effects are minimal but what i was kinda meaning. was not to stop drinking water, or bottled water, while rolling
but if your rolling and downing a lot of bottled water,
could the chems that leach into the water, and your doing E drinking lots of water ,
what i mean is ....
i wonder is if excessive bottled water intake could it possibly potentate serotonin syndrome caused by E or the water
or the next day while your serotin is depleted if you drink alot of bottled water to rehydrate and balance your system thinking you are being healthy ,
could you possibly doing more harm than good ??

sorry for posting senseless thought that could make sense
 
This concern kind of threw me, so i decided to look into it. I looked in several databases of scientific literature and reviewed most of the recent research on serotonin syndrome and was unable to find anything about this. I even googled it with no luck.

Did they list a specific chemical in any of the reports anyone has seen? I am doubtful as to the accuracy of this. There is a rather large laundry list of drugs in common use that have serotonin syndrome risk related to interactions. With something as common as food grade plastics, I would think there would be an endless amount of warnings on prescription medications and more google/science database hits then you cloud shake a stick at.
 
biocloudy said:
This concern kind of threw me, so i decided to look into it. I looked in several databases of scientific literature and reviewed most of the recent research on serotonin syndrome and was unable to find anything about this. I even googled it with no luck.

Did they list a specific chemical in any of the reports anyone has seen? I am doubtful as to the accuracy of this. There is a rather large laundry list of drugs in common use that have serotonin syndrome risk related to interactions. With something as common as food grade plastics, I would think there would be an endless amount of warnings on prescription medications and more google/science database hits then you cloud shake a stick at.
Click to expand...

You can have a read of this which explains in brief about the chemicals leaking into water from bottles. It doenst really specifically say SS (and I couldnt find any information on that when I checked up yesterday).
 
Bearlove said:
You can have a read of this which explains in brief about the chemicals leaking into water from bottles. It doenst really specifically say SS (and I couldnt find any information on that when I checked up yesterday).
Click to expand...

Thanks Bearlove, that was enough to point me in the direction to find the link, although I found no research directly relating it to SS, there appears to be some meat on this bone, just not very much...

Bisphenol A (BPA), a chemical in some plastic bottles, is linked to P450 inhibition [1], something that can create a fatal condition with MDMA (eg Ritonavir.) But the concentrations of BPA needed are huge... Your pushing 6-7ug BPA to start to push yourself out of the normal genetic functioning range of the P450 enzymes. You can estimate that you will get 10 ug per litter from a plastic bottle [2] so with a average person weighing 60 kg, they would have concentrations of ~1.33 ug after drinking 8 litters of water from BPA containing plastics. Attached chart shows P450 activity vs concentration of BPA in rats [1].

In my quick review of the data, water intoxication syndrome would be far more of a risk then BPA induced injury when consumed with MDMA. If you have a comprised P450 complex this could bring additional risks, but you shouldn't be taking MDMA in that case anyway. YMMV...

If one is very concerned about this you can avoid plastic bottles with a 7/OTHER recycle category.

[1] Nobumitsu Hanioka, Hideto Jinno, Toshiko Tanaka-Kagawa, Tetsuji Nishimura, Masanori Ando, Interaction of bisphenol A with rat hepatic cytochrome P450 enzymes, Chemosphere, Volume 41, Issue 7, October 2000, Pages 973-978, ISSN 0045-6535, DOI: 10.1016/S0045-6535(99)00529-9.
[2] United States. U.S. Department of Health and Human Services. National Toxicology Program. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A.
 

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I thought this mainly concerned distilled water, since distillation requires heating the water and the water is still quite hot when bottled - which would obviously cause some of the plastic to mix in the water
 
Gormur said:
I thought this mainly concerned distilled water, since distillation requires heating the water and the water is still quite hot when bottled - which would obviously cause some of the plastic to mix in the water
Click to expand...

Distilled water would maybe impact it a little bit but the water is still less then 100 deg. C in order to get it to condense from the still. I think you would have more of a reaction from grinding a bottle around all night as you dance with it, endlessly refilling it. But just avoiding BPA plastic bottles should do the trick and shouldn't be that difficult to do. Look at the bottom, if you are concerned, avoid a recycle 7/Other marking, none of the water bottles i just checked in my hose have this marking and are therefore BPA free.
 
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