Why anyone would use seroquel for anything other then it's intended uses such as bipolar disorder, schizophrenia, a add on drug for depression or insomnia if other drugs don't work is beyond me. It's not a pleasant drug at all. I have been on various atypical anti-psychotics and a few typical ones over the years and none of them where fun at all. Though methotrimeprazine is good for knocking you out for about 2 days straight
I didn't think seroquel was known for causing TD on it's own? I thought the risk was virtually zero unless you had been on other anti-psychotics as well but i could be wrong. Older more potent D2 antagonist atypicals such as risperidone have a much higher risk of causing TD.
Using it for sleep, depression or bipolar is beyond retarded, a mini evening dose for sleep provides enough 5HT2A antagonism to blunt your personality (it mediates dominance, decission making and other things).
^^^ The fact that its not pleasant is exactly the point. Especially for daily drug use. Will you tell me the traditional benzos are safer for regular medium term daily usage? I know there are other solutions but Seroquel worked so its fine for now (and its good for stims). Of course I wouldnt ever do this as a permanent solution.
I will be moving over to hystamine OTC meds at a certain point and coincidentally having used Seroquel I will already be familiar with histamine based sleep aid and the lack of "pleasantness" and effectiveness. Training my brain to eventually sleep naturally. Its almost like i planned this all out considering all factors hehe. I may have missed some better theoretically better solution so I will happy hear look into any suggestions.
In seriousness, It works well for sleep and is safe for temp usage. It provides a natural mechanism for sleep.
It is tolerance, addiction and dependency resistant. Its risks of side effects, to me are worth avoiding benzo or z drug dependency and breaking my drug rules about no daily usage of addictive drugs.
So all these factors made it attractive for use a mere short term tool for my current situation and satisfies my seriousness around avoiding certain dangers of drug use. And its great for stim comedowns as well which was a nice bonus and lastly im safe from psychosis as well should i catch it somehow in my travels. One less thing to worry about i suppose so thats another bonus lol.
Its like alcohol. Yeah its shit and gets you drunk but thats not everything. Certain properties it has might mean it could be used in a certain dose and with the correct knowledge for anxiety, likely for only a very short duration but im just making a point. Maybe bad example but that's my thought process with using some of Seroquels properties for my current specific needs. A bit of creative problem solving.
GHB is the safest, most effective option for sleep as it well established to be pretty much side effect free and not cause dependency when used as intended in narcolepsy patients, you may get addicted but its established that the addition of naltrexone avoids wanting to take more as prescribed in alcohol dependent patients. (Italy succesfully uses it for alcohol addiction, naltrexone abolishes the rewarding effects wich shows it doesnt work because you change one drug for another).
Also etizolam has been shown in rodents to barely produce tolerance and addiction, i was semi addicted to xanax but my benzo addiction mostly vanished after being a week on etizolam as an anecdote.
Also rodent research shows that glutamate antagonism blocks benzo addiction and anecdotal dxm reports show reversal of addiction of tolerance slowly over a period where they test DXM, altough i dont know wheter it goes to full reversal of addiction.
If stims, like meth increase the amount of dopamine released and "active" in the brain, then when coming down I understand the quantity of dopamine drops fast, perhaps past baseline and below, resulting in the negative comedown experience, anxiety, panic attacks, and any other shitty effects.
So, am i accurate that the meth comedown hell is dopamine dropped below baseline or is it the pleasant dopamine effects wear off while the SNS and peripheral stimulation is still fully active meaning you feel shit since the shitty side effects are no longer masked with the good effects? Or is it something else?
This is wrong, amphetamine wont deplete monoamines unless its taken in high doses that cause braindamage (monoamine depletion is what indicates braindamage in rodent research) the cause is rapid temporary receptor downregulation wich occurs acutely when flooding the brain with dopamine called receptor internalisation, this is differened from tolerance as it rapidly reverses and doesnt last long term.
Anwyays, I always thought Seroquel was a drug that was known by reputation and mechanism not to cause tolerance. Is this not accurate after all?
Perhaps the perceived tolerance is one of "getting used to the effects, like with other drugs?
nope, H1 antagonism causes receptor upregulation, tolerance can be expected.
If you benefit from 5ht2a antagonism like when used for depression thats a differened matter as those receptor downregulate when antagonised.
