Seligiline for gently boosting motivation

[Vastness]

Thanks, well I can't deny that sounds like some healthy shit right there.

That's a lot of different types of veg, herbs, nuts, etc... That seems like a lot of meal prep to bother with every day... But I guess if it was easy everyone would be doing it, and if it's as beneficial as you claim I guess it's worth the trouble.

I'm not proud of it but I am a really lazy cook myself honestly, I feel like I eat healthy but I try to keep it simple, eat a lot of veg and natural fat (try to keep to keto-esque levels of carbs, not true keto but 100-150g carbs day max, so full fat yoghurt, berries, mixed vegetables - usually microwaved from frozen... yeah I know, I know). Eggs, fish and beef (pretty much in that order or frequency) for meat and protein and the other good stuff from meat... generally 3 distinct items would be my max per meal. Maybe I should suck it up and learn some stuff about different types of veg and all those herbs you mention.

Getting kind of off topic here but do you pay attention to macronutrient ratios also or is that just not important compared to the micronutrients you mentioned, you think? I try to aim for 60/20/20 fat/carbs/protein, but sometimes think maybe I put too much emphasis on these ratios over the specific nutritional content of foods. I mean, obviously it's easy to get your macros right even eating garbage.

 

[Genetic Freak]

Thanks, well I can't deny that sounds like some healthy shit right there.

That's a lot of different types of veg, herbs, nuts, etc... That seems like a lot of meal prep to bother with every day... But I guess if it was easy everyone would be doing it, and if it's as beneficial as you claim I guess it's worth the trouble.

I'm not proud of it but I am a really lazy cook myself honestly, I feel like I eat healthy but I try to keep it simple, eat a lot of veg and natural fat (try to keep to keto-esque levels of carbs, not true keto but 100-150g carbs day max, so full fat yoghurt, berries, mixed vegetables - usually microwaved from frozen... yeah I know, I know). Eggs, fish and beef (pretty much in that order or frequency) for meat and protein and the other good stuff from meat... generally 3 distinct items would be my max per meal. Maybe I should suck it up and learn some stuff about different types of veg and all those herbs you mention.

Getting kind of off topic here but do you pay attention to macronutrient ratios also or is that just not important compared to the micronutrients you mentioned, you think? I try to aim for 60/20/20 fat/carbs/protein, but sometimes think maybe I put too much emphasis on these ratios over the specific nutritional content of foods. I mean, obviously it's easy to get your macros right even eating garbage.

I used to many years ago, but more emphasis on fresh and healthy with plenty of varied fats for energy, no refined sugars, the odd sweet potato, occasional white rice, gluten free pasta, once a week or once a fortnight, plus quinoa more frequently.. Everything else is varied seasonal veggies with some fruit mainly berries, herbs and spices to suit my research into health and longevity.. My body size and weight determine whether I up food content, or lower to suit desired effect..

I suppose if I was younger I might include more calories to retain more bulk, whether I'd select carbs over fats might be debatable, knowing what I know now as to 30-40 years ago when I first started.. Probably fats..!!

The metabolic process of converting food into energy seems to be where cellular damage takes place via ROS, so the less food and the less time spent converting it to energy the better for health and longevity.. Being an older person that is my major concern now..!!

I never microwave due to EMF exposure harms plus reduction in food micronutrient quantity.. Pressure cook everything.. Always cook in butter, nothing else..



Diet and Gut Microbiota in Health and Disease.

https://www.ncbi.nlm.nih.gov/pubmed/28346928

The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease.

https://www.ncbi.nlm.nih.gov/pubmed/29902436

 

[Swim15]

I know we have a few topics we may not completely agree on Genetic Freak but love reading your info on these topics and been scouring the web the past few months!

 

[Genetic Freak]

I know we have a few topics we may not completely agree on Genetic Freak but love reading your info on these topics and been scouring the web the past few months!

Tell me your preferred area of research and I'll see what I've got to pass on..

 

[Swim15]

Tell me your preferred area of research and I'll see what I've got to pass on..

Anti-aging and just overall health as related to nutrition and microbiome has been my primary focus as Ill be running gear to some extent my whole life and still want to outlive everyone who isnt.

Besides that, mostly nootropics/cognitive function with all the work Im doing in school, obviously highly related to the above topics as well.

 

[Genetic Freak]

Anti-aging and just overall health as related to nutrition and microbiome has been my primary focus as Ill be running gear to some extent my whole life and still want to outlive everyone who isnt.

Besides that, mostly nootropics/cognitive function with all the work Im doing in school, obviously highly related to the above topics as well.

There seems to be growing evidence to strongly suggest the area inside the cell where damage starts is the mitochondria, either through overproduction of oxidative or nitrogen free radicals, or slowing of the cellular communication process within that cell or between other cells..
Create optimal mitochondrial function, everything else within that cell, and therefore every other cell is taken care of..

If you think about it, each cell is generally involved and closely linked with many other similar cells that come together to do a specific task, ie: muscle cells are responsible for movement, connective tissue load, myocardium to pump, pulmonary to breath, pancreatic insulin, glucagon etc, bone for support, neural memory etc, plus our lymphatic system pathogen control, and everything else that supports a healthy immune system, etc, etc..

When you look from a cellular level, you can see how if we create problem within that cell(s) how it can affect larger biological process and thus create a problem, whether acute or chronic within the body..

What is covered in the first chapter of all Anatomy and physiology or biology books (mine at least)? The cell... Look after the cell you look after everything else..
If damage or breakdown in communication within that cell originates from mitochondria then it seems logical that is where we should start, with no need to progress anywhere else..!!

I strongly suggest you read "Headstrong" by Dave Asprey, his book discusses optimal brain function, but obviously includes mitochondrial health, with all his references in the back of the book... Follow the paper chase..!!
Zach Bush is worth following up too..

A few links to get you going in different directions, for full papers: https://sci-hub.tw/


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755412/

https://www.ncbi.nlm.nih.gov/pubmed/27532080 (search for this, it' possible to download the whole book for free)

https://www.ncbi.nlm.nih.gov/pubmed/21193540

https://www.ncbi.nlm.nih.gov/pubmed/15797866

https://www.ncbi.nlm.nih.gov/pubmed/21248165

https://www.emfacts.com/2017/05/a-5...art-nation-or-contribute-to-an-unhealthy-one/

https://www.ncbi.nlm.nih.gov/pubmed/30255333

https://www.ncbi.nlm.nih.gov/pubmed/29573716

https://www.ncbi.nlm.nih.gov/pubmed/25411471

https://www.ncbi.nlm.nih.gov/pubmed/21045839

https://www.ncbi.nlm.nih.gov/pubmed/25503498

https://www.ncbi.nlm.nih.gov/pubmed/22247744

 

[Swim15]

There seems to be growing evidence to strongly suggest the area inside the cell where damage starts is the mitochondria, either through overproduction of oxidative or nitrogen free radicals, or slowing of the cellular communication process within that cell or between other cells..
Create optimal mitochondrial function, everything else within that cell, and therefore every other cell is taken care of..

If you think about it, each cell is generally involved and closely linked with many other similar cells that come together to do a specific task, ie: muscle cells are responsible for movement, connective tissue load, myocardium to pump, pulmonary to breath, pancreatic insulin, glucagon etc, bone for support, neural memory etc, plus our lymphatic system pathogen control, and everything else that supports a healthy immune system, etc, etc..

When you look from a cellular level, you can see how if we create problem within that cell(s) how it can affect larger biological process and thus create a problem, whether acute or chronic within the body..

What is covered in the first chapter of all Anatomy and physiology or biology books (mine at least)? The cell... Look after the cell you look after everything else..
If damage or breakdown in communication within that cell originates from mitochondria then it seems logical that is where we should start, with no need to progress anywhere else..!!

I strongly suggest you read "Headstrong" by Dave Asprey, his book discusses optimal brain function, but obviously includes mitochondrial health, with all his references in the back of the book... Follow the paper chase..!!
Zach Bush is worth following up too..

A few links to get you going in different directions, for full papers: https://sci-hub.tw/


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755412/

https://www.ncbi.nlm.nih.gov/pubmed/27532080 (search for this, it' possible to download the whole book for free)

https://www.ncbi.nlm.nih.gov/pubmed/21193540

https://www.ncbi.nlm.nih.gov/pubmed/15797866

https://www.ncbi.nlm.nih.gov/pubmed/21248165

https://www.emfacts.com/2017/05/a-5...art-nation-or-contribute-to-an-unhealthy-one/

https://www.ncbi.nlm.nih.gov/pubmed/30255333

https://www.ncbi.nlm.nih.gov/pubmed/29573716

https://www.ncbi.nlm.nih.gov/pubmed/25411471

https://www.ncbi.nlm.nih.gov/pubmed/21045839

https://www.ncbi.nlm.nih.gov/pubmed/25503498

https://www.ncbi.nlm.nih.gov/pubmed/22247744

Appreciate those Genetic Freak! Have been reading through between class stuff/tests and going to continue to do so

 

[Swim15]

I do want to continue this thread on the OP's topic as I have been looking into a few of these things myself now actually.

An initial thought was to try memantine for reducing stimulant tolerance but I am not currently sold on that one based on some potential side effects and reduced cognitive plasticity in relation to learning.

My next thought was looking at selegiline as well. I am currently prescribed Adderall 20mg XR BID although have bounced between 0-100mg/day the past year depending on what I'm doing (take nothing for low workout but typically do not go over max prescribing 60mg/day even with very high workloads).

Looking at reducing adderall to 10mg QD-BID to start in combination with 1.25-2.5mg selegiline BID after reading up on some of the potential neuroprotective mechanisms and literature on the safety of low dose administration. Does anyone have experience with this or any side effects after coming off the selegiline? I wouldn't think they would be likely for me as these drugs have worked well with my body chem and have been very forgiving with virtually no sides so far but still cautious on some of these combos.