• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Selegiline effect duration

J

Joe75

Greenlighter
Joined
May 16, 2008
Messages
10
Hi

I try to use seliginine to reduce craving when suddenly stoping ritalin or amphetamin use (daily use) it seems to help a litle bit.

But i wonder how long it takes for the mao-b to recover? how long does it take till the Mao-b is back at normal level? Its an irreversible inhibitor so the mao-b has to build completely new to recover.

I also experimented with selegine and amphetamine and ritalin together. it seems to be not unpleasant if i get the right dose. ((I know that its stupid and dangerous to try that, don´t tell me that. Its like Russian roulette and could kill me. when i took a litle bit more than the good dose it became very very painful. don´t do it unless you want to commit suicide in a very painful and horrible way.))

joe
 
Once I took 2.5 mg of selegiline a day for about 3 weeks. It took me 3 more weeks to feel normal again. Shit trip that was. But then again I don't like stimulants in general.
 
It was never a trip. Nothing remotely in common with a 'trip.'

Unfortunately it's not even much of a stimulant. The first time isn't bad, it was easily as good as amphetamine, and the second day was nearly as good.

By the end of 50 days, though, it was just keeping me happy.
 
Selegline has a number of new studies of emerging negative findings.


i used to take selegiline, after 1 week of daily use of 5mg.
i would start feeling drowsy, irritated and just a angry cunt.

Stimulant effect? asfuckingif
Motivation booster? no way in hell
Boosts the effects of stimulants? nope, it even dampens it, though incase of Ritalin, it turns it to a speed bomb
Boosts the effects of PEA, or PEA drugs (2c-b)? yes, in a very life threatening way if not taken caution of

The drug it self has a maximum half life of 9 hours...
BUT its effect on the MAO-B is irreversible until new MAO-B replaces the existing one


after i stop taking it , it takes a couple of weeks to feel normal again.
 
Hammilton said:
It was never a trip. Nothing remotely in common with a 'trip.'
Click to expand...

Yeah we use the word 'trip' quite loosely. We sometimes apply it to any subjective experience, drug related or not.

For me, the selegiline experience was a constant state of nervous, drowsy tenseness similar to the one I get from caffeine but more subdued. The only positive aspect was a noticeable increase in physical stamina.

But worst of all was the emotional blunting and anhedonia. I felt like a robot on it. And it lasts a while too until it wears off.
 
The effects on 2c-t-2 were PROFOUND. I had been taking about 5-10 mg LIQUID selegiline (ordered as an RC WAY back in the day) a day for like 10 days, then I dosed 15 mg 2c-t-2. I literally could not see, there were so many lasers. My normal dose was about 25 mg, a dose at which I felt fully competent to *drive* even. I aborted the trip with 60 mg Temazepam. I mean, it wasn't a full abort, but it got easier :P

I tried again a week later at 7 mg, expecting little effect. It took hold slowly; I thought not much would happen, but it kept getting stronger and stronger. I was blasted out of my skull, feeling psychic vibrations, etc.

Funny thing is, I *didn't* feel life-threatening effects. The body load was lighter than 2c-t-2 normally was, and there was no increase in heart rate, etc. Trip was 12 hours long, and I felt *fantastic* the next day.
 
Yesterday I experimented with just a single 1.25 mg dose of selegiline and am not enjoying the effect at all. How long do you all figure it will take to go back to baseline?

Also, I know this is a stretch, but is there any way to speed up the recovery process (short of a transfusion of course)? For example, do MAO antagonists/inducers exist?

Really appreciate the feedback. Thanks!
 
Last edited:
2 weeks, it's an irreversible inhibitor.
The acute half life of the drug is only an hour and a half or so.

There's no way to feel better aside from a high protien diet.
 
Partial though. Thats why I'm thinking if one could boost the molecules that have not been inhibited it could balance out the problem.

What a crap drug!
 
No, it's a really great drug. If you have parkinson's or depression. As a recreational drug, not so much. was pretty amazing with phenethylamine, though.
 
yeah, the selegiline offers little in the way of psychoactivity after the first dose or two. the phenethylamine, otoh, was pretty good.
 
sekio said:
There's no way to feel better aside from a high protien diet.
Click to expand...

Can you explain why a high protein diet can have an impact on a selegiline treatment?

I personnaly enjoy some great motivation with my curent 2.5mg a day out of two. I think the less is the better, don't search for recreationnal effets guys! An do somebody can give me methylone and selegiline combo feedback?

I have to give a try to PEA, but it's totally absent of pharmacie shops in my place...
 
I have a couple years of experience with transdermal selegiline (Emsam), usually used for 2-3 weeks on and 1-2 weeks off--though I've tried other combinations of shorter on and longer off. I have heard that it takes 40 days to completely cycle MAO-B, but it is true that for practical purposes enough MAO-B is regenerated in 2 weeks to eliminate any effect from the original selegiline administration.

I'm stunned at some of the experiences that you guys report, especially tiredness and emotional muting. On Selegiline, I always have more energy, a more positive mood, and feel quite thoroughly alive in general. Huge motivation booster, absolutely no doubt there.

However--raising dopamine also results in a raise in testosterone (read about the details of the pathway, it's established), and while this results in some positive effects (significant boost to sex drive, enjoyment, and stamina; better results from gym workouts), it also generates more DHT. As a result, my hair started thinning prematurely, and I eventually identified direct relationship between selegiline and hair loss. It manifested at as tingling sensation on the scalp, which I didn't think of much until I noticed the thinning, and from that point determined the clear association between the occurrence of that tingle, use of selegiline, and progression of the thinning. There's no doubt I'm one of the people destined for hair loss in later life anyway, but I also am convinced that I would have a lot more hair right now had I not used selegiline regularly.

Regardless, I've experienced many dozens of drugs and selegiline is still one of my favorite. It's quite an extraordinary drug with some substantial benefits to the brain (most particularly reduction of free radicals that are generated when metabolizing dopamine, as well as its role in refreshing superoxide dismutase). It has many positive cognitive effects, but is not without testosterone-related side effects.
 
tihkal said:
I personnaly enjoy some great motivation with my curent 2.5mg a day out of two. I think the less is the better, don't search for recreationnal effets guys! An do somebody can give me methylone and selegiline combo feedback?
Click to expand...

I would treat it like combination with MDMA (as detailed in my FAQ; I only suggest as I know you're familiar with it :P). You'll need to start very low (Shulginesque titration, ideally), and beware of potentiation of dopaminergic and adrenergic fx eclipsing increased 5ht release. I had an acquaintance (well...internet acquaintance) wander into worrying cardio push territory with this combo, so please take care...or reconsider the combo.

ebola
 
ebola? said:
I would treat it like combination with MDMA (as detailed in my FAQ; I only suggest as I know you're familiar with it :P). You'll need to start very low (Shulginesque titration, ideally), and beware of potentiation of dopaminergic and adrenergic fx eclipsing increased 5ht release. I had an acquaintance (well...internet acquaintance) wander into worrying cardio push territory with this combo, so please take care...or reconsider the combo.

ebola
Click to expand...

Methylone play more with dopamine than her sister MDMA (that's not a really rigorous sentence but anyway), so I wonder if it really the same than MDMA, maybe greater risk! Thanks again for your FAQ hehe, an usefull work for this dangerous teritory. I have to find some benzos, this can help a bit in a case of little overdosage. Given the increase speedy effect when you redose methylone, I think that 2 dose may be too much in this combo.

I found that you have to carefully ad cafeine with selegiline. That's easy to spend too much energy in a week or two without even notice it, and take a few day to recover. (that's not really a hangover but I need all my mental energy for studying, and 2 weeks with 2/3 coffe cups was to much for me, I wasn't at 100% during a whole week after this!) Anyway, I'm really happy to have this new tool in my chembox.
 
Please take care: benzodiazapines will readily treat panic and according tachycardia, but they won't very effectively lower blood pressure or heart rate directly.

ebola
 
ebola? said:
Please take care: benzodiazapines will readily treat panic and according tachycardia, but they won't very effectively lower blood pressure or heart rate directly.

ebola
Click to expand...

That's why I wrote little overdose. I may have written "panic attack" and not "overdose". Thanks anyway for the precision!

I decided that my setting (my birthday) isn't the perfect setting at all for ala "shuglin titration". Will stop deprenyl 2 weeks before, that's far better, will try this combo an other time ;)
 
Last edited:
You must log in or register to reply here.
Top