BeanDreams
Bluelighter
I just got my xannax filled and there is a warning lable on it that says " Do not take with grapefruit juice! " Anybody know why ? Do they work better when u slam them with grapefruit juice ??
-
OD Moderators: Keif’ Richards | Tryptamino
Script says " Do not take with grapefruit juice"
- Thread starter BeanDreams
- Start date
Well, grapefruit juice is fairly acidic, and enough of it could decrease your stomach's ph level (meaning acidity is increased). The pill makers could be concerned with two things.
1.) Increased acidity in the stomach might render the pill uneffective.
2.) Increased acidity in the stomach might cause the pill to be broken down quicker, digested quicker, and maybe produce a slight buzz - which could be psychologically addictive. (But I must say that 2 is shot in the dark).
But what bothers me about this is the fact that it would probably take a shit load of juice to significantly decrease stomach ph-so why the fuck are the worried?
1.) Increased acidity in the stomach might render the pill uneffective.
2.) Increased acidity in the stomach might cause the pill to be broken down quicker, digested quicker, and maybe produce a slight buzz - which could be psychologically addictive. (But I must say that 2 is shot in the dark).
But what bothers me about this is the fact that it would probably take a shit load of juice to significantly decrease stomach ph-so why the fuck are the worried?
liquid ocean
Bluelighter
from what i've heard from friends, grapefruit juice inhibits a certain enzyme in the liver that helps break down foreign chemicals that are introduced into the body, thus increasing their effect.
i drink 8-16 oz. of GF juice when taking mdma, and i am able to feel like i'm rolling rather well off of 1/2 a pill (my tolerance is low), but i won't necessarily draw a direct conclusion.
can anybody confirm or deny this?
i drink 8-16 oz. of GF juice when taking mdma, and i am able to feel like i'm rolling rather well off of 1/2 a pill (my tolerance is low), but i won't necessarily draw a direct conclusion.
can anybody confirm or deny this?
PhreeX
Bluelight Crew
This is a really good site... it's called "The grapefruit juice effect" ... there is also a list of medication here - YES, you had BETTER DRINK SOME GRAPEFRUIT JUICE WITH THOSE BENZOS ... the website: http://pharmacology.about.com/health/pharmacology/library/weekly/aa000522a.htm
Here is part of the article -
The mechanism of the grapefruit juice effect is probably that one or more of the chemicals (most likely bioflavonoids and/or furanocoumarins) in grapefruit juice decreases the amount of (or inhibit the activity of) one or more specific enzymes in the intestinal wall and liver. These enzymes include CYP1A2, CYP3A3, and CYP3A4, which are part of the cytochrome P450 (CYP) family of enzymes. The CYP3A family of enzymes is thought to metabolize or inactivate approximately 60% of all drugs. These enzymes normally decrease the amount, via metabolism, of certain drugs which enter the systemic circulation. Thus when the enzyme is inactivated or the amount decreased, the amount of the drug entering the bloodstream is increased. This can result in increased therapeutic activity and possibly toxicity of the drug. Cytochrome p450 3A4 (CYP3A4) is currently thought to be the major enzyme affecting drug metabolism which is inhibited by grapefruit or grapefruit juice. Hence, any drug normally metabolized by that enzyme may show increased effectiveness and/or toxicity when taken with grapefruit juice. Such drugs are listed in The Grapefruit Juice Effect: Part 2 - Medications List.
Although the emphasis has been on possibly dangerous interactions of drugs and grapefruit, the interaction can also be beneficial. According to the Boston Globe, a kidney transplant patient began taking grapefruit juice along with the immunosuppressant cyclosporin, and cut the cost of his medication from $12,000 a year to $6,000. Some drug manufacturers are now trying to incorporate the active ingredients of grapefruit juice into various pills to increase their availability after oral administration. In fact, one company, AvMax, Inc., was recently issued a patent for this technology. That company hopes to develop oral dosage forms for some anticancer drugs, such as Taxol and Taxotere, which can currently be administered only intravenously.
------------------
dot slash 0wn3d
Here is part of the article -
The mechanism of the grapefruit juice effect is probably that one or more of the chemicals (most likely bioflavonoids and/or furanocoumarins) in grapefruit juice decreases the amount of (or inhibit the activity of) one or more specific enzymes in the intestinal wall and liver. These enzymes include CYP1A2, CYP3A3, and CYP3A4, which are part of the cytochrome P450 (CYP) family of enzymes. The CYP3A family of enzymes is thought to metabolize or inactivate approximately 60% of all drugs. These enzymes normally decrease the amount, via metabolism, of certain drugs which enter the systemic circulation. Thus when the enzyme is inactivated or the amount decreased, the amount of the drug entering the bloodstream is increased. This can result in increased therapeutic activity and possibly toxicity of the drug. Cytochrome p450 3A4 (CYP3A4) is currently thought to be the major enzyme affecting drug metabolism which is inhibited by grapefruit or grapefruit juice. Hence, any drug normally metabolized by that enzyme may show increased effectiveness and/or toxicity when taken with grapefruit juice. Such drugs are listed in The Grapefruit Juice Effect: Part 2 - Medications List.
Although the emphasis has been on possibly dangerous interactions of drugs and grapefruit, the interaction can also be beneficial. According to the Boston Globe, a kidney transplant patient began taking grapefruit juice along with the immunosuppressant cyclosporin, and cut the cost of his medication from $12,000 a year to $6,000. Some drug manufacturers are now trying to incorporate the active ingredients of grapefruit juice into various pills to increase their availability after oral administration. In fact, one company, AvMax, Inc., was recently issued a patent for this technology. That company hopes to develop oral dosage forms for some anticancer drugs, such as Taxol and Taxotere, which can currently be administered only intravenously.
------------------
dot slash 0wn3d
Jabberwocky
Frumious Bandersnatch
Nod to Phreex above^^^.
One of the chemicals found in grapefruit juice monopolizes one of the liver's specific metabolic enzymes, namely the Cytochrome P450 isoenzyme 3A4.
Think of grapefruit juice as the front line of an army - it keeps the enemy (your liver enzymes)occupied (monopolized) while the drug is able to freely circulate without being metabolized and excreted from the body as quickly. The net effect is a stronger and/or prolonged duration of action of the drug. It is a week effect, but a legitimate one nonetheless.
------------------
"I dislike the drug you are using, but I would defend with my life your right to use it."
- Paraphrase on Voltaire
"He who makes a beast of himself gets rid of the pain of being a man."
- Dr. Johnson
"We do not sense imagination enough to sense what we are missing."
-Jean Toomer
One of the chemicals found in grapefruit juice monopolizes one of the liver's specific metabolic enzymes, namely the Cytochrome P450 isoenzyme 3A4.
Think of grapefruit juice as the front line of an army - it keeps the enemy (your liver enzymes)occupied (monopolized) while the drug is able to freely circulate without being metabolized and excreted from the body as quickly. The net effect is a stronger and/or prolonged duration of action of the drug. It is a week effect, but a legitimate one nonetheless.
------------------
"I dislike the drug you are using, but I would defend with my life your right to use it."
- Paraphrase on Voltaire
"He who makes a beast of himself gets rid of the pain of being a man."
- Dr. Johnson
"We do not sense imagination enough to sense what we are missing."
-Jean Toomer
zApo
Bluelighter
so if u wanted to use grapefruit juice with recreational drugs, would u drink a glass before you dose, after a while, when?
PhreeX
Bluelight Crew
About 20 minutes prior, taken a nice big glass.... then wash those pills down with some, and a booster glass as you start to feel its effects!
------------------
dot slash 0wn3d
------------------
dot slash 0wn3d
StoneHappyMonday
Bluelighter
- Joined
- May 10, 2001
- Messages
- 18,084
Bean Dreams, you are my kind of drug taker.
"It says don't double the dose"
"Better triple it then"
And I think I'll have to down a pint of grapefruit juice the next time I take an E...great thread
------------------
Ecstasy Liberation Front
"It says don't double the dose"
"Better triple it then"
And I think I'll have to down a pint of grapefruit juice the next time I take an E...great thread
------------------
Ecstasy Liberation Front
Party_Animal
Ex-Bluelighter
Hmm I'll have to try this before MDMA.
------------------
http://www.epo.20m.com
Whatever you look for, is the focus
------------------
http://www.epo.20m.com
Whatever you look for, is the focus
Grapefruit juice (or anything that acidifies your stomach) speeds up the excretion of amphetamines. Therefor, basifying your stomach before using speed should allow more of the drug to enter the bloodstream.
This is from rxlist.com regarding Dexedrine:
This is from rxlist.com regarding Dexedrine:
Grapefruit juice may potentiate Benzos, but I would think that speed/E users would benefit more from a club soda prior to ingestion.
BeanDreams
Bluelighter
Thanks for the info !! I'm headin' to the store to get some grapefruit juice !
ok , milk is basic , right ? last time i ate way too many pills(which was when i lived at home) , my mom told me to drink some milk as to help get rid of the drugs in me . well i think the pills i had were just straight amphetamine , so she was trying to put me 6 feet under ?
============================================
wonderful , first glow sticks , now grapefruit juice will be considered paraphanalia (sp?) .........
[This message has been edited by BecomeZen (edited 08 August 2001).]
============================================
wonderful , first glow sticks , now grapefruit juice will be considered paraphanalia (sp?) .........
[This message has been edited by BecomeZen (edited 08 August 2001).]