salvia tolerance?

[rashandreflex]

if salvia acts on the kappa opioid receptors, and the kappa opioid receptors are responsible for causing opiate tolerance, do people develop tolerance to salvia, or do the kappa receptors only have that effect with opiates?...just wondering as i've never heard anyone talk about salvia dependence (maybe bc no one uses it frequently enough?)

 

[BilZ0r]

Who says kappa opioid receptors cause opiate tolerance? I would say mu opioid receptor downregulation is the cause of opiate tolerance.

 

[rashandreflex]

i had been thinking of diacetyldeath's second post toward the bottom of the first page in this http://www.bluelight.ru/vb/showthread.php?t=255913&highlight=avoding thread, but upon closer inspection he actually said the delta opiois receptor played a role in tolerance development, not the kappa opioid receptor, and he didn't preclude the possibility that mu opioid receptor downregulation caused tolerance except for his claim that a pure mu-1 agonist would not cause tolerance. i guess you can close this thread.

 

[Gaz_hmmmm]

I once did salvia 3 times in the space of about 20-30mins. The second and third times were crap, compared to the first.

You build a tolerance to it!

 

[jasoncrest]

I think there could be some kind of Addiction to Salvia if it was a long-lasting substance.

(I think that some people can enjoy the effects and get gigh on Kappa recptors agonists or partial agonists, like Pentazocine or Nalbuphine, and become addicted to them...)

 

[000Shaman000]

"People often fail to achieve significant effects with initial attempts. Anecdotal reports suggest for some the possibility of increasingly stronger effects with repeated use of similar amounts of Salvia. This could be attributable to the practice and learning of more efficient ingestion techniques. Some suggest however that 'reverse tolerance' or increased sensitisation may otherwise be a phenomenon of the active principle. Some people (sometimes called Salvia 'hard-heads') seem to be anyway quite resistant. For others the results can be variable.

Onset of the effects may be subtle and not immediately noticeable. There is often a few seconds of preceding 'latency'. In any case, caution is advised if considering further ingestion before time has been allowed for prior amounts to clear the system."-Wikipedia
Salvia

 

[LysergicEpiphany]

Does Salvinorin A have a tolerance ? Got a half oz bottle of tincture on the way and i dont want to waste any Peace.