Role of Endocannabinoids in 5-HT2 Receptor-Mediated Effects

[Blowmonkey]

I can't believe this hasn't been posted yet.. Had seen it ages ago and assumed it was posted in ADD immediately, as well, it's been done by an old, regular contributor of this forum..

Pretty interesting stuff:

Role of Endocannabinoids in 5-HT2 Receptor-Mediated Effects
William M. Connelly1 and Matthew J. Baggott2
1Department of Pharmacology and Toxicology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand; and 2Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California

ABSTRACT

Endocannabinoids are lipid retrograde messengers that can be released by postsynaptic depolarization and/or activation of certain metabotropic receptors. We review a recent report that activation of metabotropic 5-HT2 receptors by endogenous serotonin induces the release of endocannabinoids in the olivary nucleus and suppresses glutamatergic input through a presynaptic action. This serotonin–endocannabinoid interaction has implications in the pathophysiology of pain and mental illness and raises the possibility that drugs targeting the 5-HT2 receptor may act by modulating endocannabinoid release.

http://jn.physiology.org/cgi/content/abstract/101/1/5

 

[lenses]

I remember reading a research paper concerning endocannabinoids and their effect on upregulation of 5HT receptors. Makes sense , especially concerning the hyperemesis syndrome (sp?) articles that have been floating around .

Cannabinoids probally have a general upregulation effect on monoanime receptors in general.

-lenses