Snake_Eyes
Bluelighter
- Joined
- Aug 14, 2011
- Messages
- 1,522
Tell him/her the gabapentin is no longer working and hope for the best.
Just to let you know it's a very expensive drug.
Just to let you know it's a very expensive drug.
Tell him/her the gabapentin is no longer working and hope for the best.
Just to let you know it's a very expensive drug.
Uhh yeah, like opioid tolerance could be reversed by administering naloxone/naltrexone. Does that make it a viable option? No. Flumazenil would induce seizures in GABAergic-dependent individuals (including Lyrica I would imagine....), and Naloxone would induce precipitated withdrawals in opioid tolerant individuals.
As far as the NMDA antagonists and amphetamine tolerance issue, NMDA antagonists only do so much, they are not at all the panacea people make them out to be. Can tell you from experience.
Sorry to bump such an old thread, but I just had to share my experience with this drug:
-Took 4mg of Clonazepam and 1200mg of Lyrica everyday for 1 year (a bit less probably, like 10 months)
-After that the Lyrica stopped working, it felt as if I was taking sugar pills, but felt no withdrawal
-These things that helped me the most: Using a high dose of memantine (helped the most) and an extremely low dose of amisulpride (25 to 50mg), I personally believe memantine helped the most, but still, it never felt as the first time I tried Lyrica.
The rationale for using the Amisulpride is that it upregulates GHB receptors (although I don't know if it achieves this at the low doses I used, but at such low doses it would elevate Dopamine levels by blocking Dopamine autoreceptors), Lyrica potentiates the enzyme that transforms Glutamate to GABA (Glutamic Acid Decarboxylase) and so elevates global levels of GABA which in turn transform into GHB activating GHB receptors, hence the "XTC feeling" it gives you. I may be wrong though, or it could have been placebo, but at least in my case, it kinda worked.
The rationale for using memantine is simple: it blocks NMDA receptors, and I found anecdotical reports that it greatly potentiates Lyrica. Some of those reports even here in Bluelight.
LaCster also recommended me (via PM) to combine Lyrica and Gabapentin, "Super Lyrica" we called it, but not at the same time because they are absorbed by the L-aminoacid transporter and so they compete with each other. He also recommended using DXM instead of Memantine. Using Gabapentin worked very well I must say, and DXM was ok and it will definetily help you too if you can't get Memantine.
I've never shared this with anyone so I hope it helps or inspires someone,
Charles Ferdinand.
yes for the amisulpride potentiating method , for the NMDA receptor you might wanna try TIANEPTINE AKA stablon good combo
im interested in the dxm lyrica combo cause DXM is a stimulant and might kill the lyrica euohoria you would need more benzo thought
I have used Lyrica off and on for about a decade. Now days, I use it usually once a week (sometimes twice if I?ve got plans) at about 300-600, depending. I have gone much higher to get a fun buzz, but I keep it around 450 because I mostly use it for work, not fun these days. 450 leaves me motivated, slightly happier and much less anxious. Around 1500 gets me pretty buzzed but I don?t do dosages that high anymore for tolerance reasons. I also use Phenibut once weekly. I?ve recently added forasectam and I?ve noticed my tolerance for both drugs have went down despite I?m dosing the same as always.
I like the recreational effects of Lyrica (as well as gabapentin and Phenibut) but it?s such a useful tool in my life that I have a schedule so I don?t abuse them.
^Thanks Pharmacybandit
the only side effects of Pregabalin I've noticed so far is loss of libido and an odd numbness in my top lip. I'd better weigh myself soon
Lyrics makes you crave carbs really bad... Especially sweets... A but self control can negate weight gain but it's hard.
As for tolerance, it rises after 2-3days then literally no amount of the drug will do anything recreational. (but it is much more dangerous than first thought when it was introduced).