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  • BDD Moderators: Keif’ Richards

Reversing antihistamine tolerance

Gruesome_hound

Greenlighter
Joined
Apr 26, 2012
Messages
5
Hi folks,

I've a huge problem and need your help.

I suffer greatly under both anxiety and chronic insomnia. In the past, I was quite sucessful in overcoming sleeplessness by taking H1 antihistamine agents (Promhetazine, Levomepromazine, Melleril, Quietapine, Doxepine, Benadryl, Mirtazapine and so on and so forth.).

Unfortunately I built up with time a very strong tolerance to the sleep-inducing effects so that in the end I could only fall into sleep with Mirtazapine (45 mg) and Levomepromazine (100 mg) and even so there was no guarantee I would achieve it.

For that reason I decided one month ago to take an antihistamine drug holiday/break of two months so as to reverse my tolerance. I'm currently rotating between benzodiazepines and chloralhydrate in order to find sleep.

Alas, I unwittingly took 25 mg of Levomepromazine yesterday which I crunched in my mouth, believing it was a benzo. As I realized my mistake due to the sour taste of the pill, I quickly spat it out and then cleaned up my mouth with water I also spat out.

In spite of that effort, I fear I might have swallowed a small quantity of the levomepromazine pill since the sour taste was still present in my mouth afterwards.


Now my question would be: could that interfere with my drug-holiday and abstinence from antihistamines?

In other words, in one month will my tolerance be as low as after two normal months of abstinence or higher due to the mistake I made yesterday?

Maybe my worries are groundless.




Many thanks for your answers and advice!
 
Simple answer: no.

Long answer: You probably didn't absorb enough drug to have any effect.

ps this is not advanced.
 
Tolerance to the sedation caused by antihistamines builds extremely fast.

I think taking a break from them is a good idea and that the small amount you may have absorbed from accidentally putting one in your mouth should not negate your progress.

Be careful with the benzos though, you don't want to be dependent on them.
 
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