Repetitive hallucinations

[xxtony77]

Hi, i was reading your discussion of repetitive geometries which you inferred may result from the non linearity of cortex dynamics and i think i may have a link you would enjoy. Jack Cowan has worked on this and has been able to map complex geometries to the patterns of activity found in V1. Without further ado here is the link http://www.archive.org/details/redwood_center_2006_02_14_cowan. In your post you mentioned that you work in neuroscience. I was wondering how much work has been done with regards to the angular gyrus being the mediating structure between entrainment of neural ensembles. It seems possible considering the area is implicated in synasthesia and metaphor which result in multi modal representations of perception. Also there is (are) stereotyped gene(s) that are expressed by individuals presenting with synesthesia. It has been propsed in a recent paper in 2008 (psychophramcology of synasthesia) that 5HT 2A receptors present with different structures mediating modified functionality. Considering it has long been known that agonism at 5HT 2A receptors mediate much of the hallucinogenic properties of pharmacological agents it seems quite possible that modified behavior may manifest greatly altered perception. Also sealfon at sinai recently discussed branching and variable up regulation of signal transduction pathways at 5HT 2A receptors where agonism alone does not ensure hallucinogenic properties e.g. lisuride. The up regulation of Src and pertussin sensitive g protein associated with serotonergics ala LSD. He also showed there is upregulation of a receptor complex of 5HT 2A with mGluR2 found in schizophrenics.His lab implicated this dimer's presence in causing behavioral correlates of hallucinations (or rather the presence of hallucinogenics on board). Are these two receptor populations represented in the angular gyrus? I was wondering if Src and pertussin sensitive G protein have been implicated in the up regulation of this dimer in mentally healthy imbibers of psychedelics ? Obviously this would be an intersting target for theraputic study with relation to psychosis considering most mental issues present with abberant EEG recordings during sleep possibly indicating destruction of normal communication between neural ensembles. On a side note the angular gyrus is very close to the belt/parabelt areas associated with audition. Interestingly activity in these areas are correlated with the presentation of complex periodic wave stimuli (tones). I am a junior biochemistry student and i really want to do neuroscience related to oscillation research. Is there any advice you could give me about graduate school? What tools and techniques haven proven indispensable for you research?

 

[xxtony77]

Also i like to think that fractal geometries are the closest manifestation to reality as we can conceive. Reality being a vast vibrating network of networks of networks ...displaying complexity in phenomenon from chemical equilibrium, cell biology, physiology, neural tissue, climate and weather. Perhaps these patterns seem so important because they reflect the dynamics at play in all of nature.

 

[ShaolinBomber]

Sounds like everyday psychedelic hallucinations imo. I've hallucinated more than anyone responding to your thread here, and im not trying to brag about how much drugs i've taken, because i havn't taken much at all.

Unless someone else here suffers from persisting visual disturbances every second of everyday then i am mistaken, but i doubt it!

My condition is a simple MALFUNCTIONING of visual processing, an uncoupled system of sorts that makes me hallucinate when looking at something should only produce normal excitation waves in someones visual cortex. Instead, i get disinhibition and my visual field constantly fires over threshold and i see all kinds of shit all the time. Its an endless list of visual disturbances that i dont care to list right now but its basically the fundamental hallucinations you'd get on most psychedelic compounds.

 

[greenmeanies]

so you have persistent distracting hppd? my condolences, that must suck when you're trying to get shit done. are there things/activities that change its intensity?

 

[ShaolinBomber]

so you have persistent distracting hppd? my condolences, that must suck when you're trying to get shit done. are there things/activities that change its intensity?

Strenuous physical work will usually produce certain disturbances like sparks and flashes of metallic stars in the peripherals to increase in frequency, and being tired will increase visuals ALOT. Even a couple visuals i dont get when rested will present itself when im over 30ish hours with no sleep.

 

[Pegasus]

When I first started smoking cannabis, for the first twenty or so times I would get a closed-eye-visual that was a collage of various different objects and patterns that I could not possibly begin to describe right now, but would always be there upon closing my eyes.

Yeah, I'm glad you brought that up. I hadn't thought about it until now, but I did have some pretty unique closed-eye visuals when I began smoking, around age 16 or so.

 

[rpm]

Hi, i was reading your discussion of repetitive geometries which you inferred may result from the non linearity of cortex dynamics and i think i may have a link you would enjoy. Jack Cowan has worked on this and has been able to map complex geometries to the patterns of activity found in V1. Without further ado here is the link http://www.archive.org/details/redwood_center_2006_02_14_cowan. In your post you mentioned that you work in neuroscience. I was wondering how much work has been done with regards to the angular gyrus being the mediating structure between entrainment of neural ensembles. It seems possible considering the area is implicated in synasthesia and metaphor which result in multi modal representations of perception. Also there is (are) stereotyped gene(s) that are expressed by individuals presenting with synesthesia. It has been propsed in a recent paper in 2008 (psychophramcology of synasthesia) that 5HT 2A receptors present with different structures mediating modified functionality. Considering it has long been known that agonism at 5HT 2A receptors mediate much of the hallucinogenic properties of pharmacological agents it seems quite possible that modified behavior may manifest greatly altered perception. Also sealfon at sinai recently discussed branching and variable up regulation of signal transduction pathways at 5HT 2A receptors where agonism alone does not ensure hallucinogenic properties e.g. lisuride. The up regulation of Src and pertussin sensitive g protein associated with serotonergics ala LSD. He also showed there is upregulation of a receptor complex of 5HT 2A with mGluR2 found in schizophrenics.His lab implicated this dimer's presence in causing behavioral correlates of hallucinations (or rather the presence of hallucinogenics on board). Are these two receptor populations represented in the angular gyrus? I was wondering if Src and pertussin sensitive G protein have been implicated in the up regulation of this dimer in mentally healthy imbibers of psychedelics ? Obviously this would be an intersting target for theraputic study with relation to psychosis considering most mental issues present with abberant EEG recordings during sleep possibly indicating destruction of normal communication between neural ensembles. On a side note the angular gyrus is very close to the belt/parabelt areas associated with audition. Interestingly activity in these areas are correlated with the presentation of complex periodic wave stimuli (tones). I am a junior biochemistry student and i really want to do neuroscience related to oscillation research. Is there any advice you could give me about graduate school? What tools and techniques haven proven indispensable for you research?

That video was very interesting. Sorry, am a bit to overhung to post coherently right now so I will get back to you later. To get into oscillation reserarch for you would be easy. Just find a PhD in a good university. Biochemistry is related enought that you would be welcomed with open arms. In terms of techniques, EEG & MEG (non-linear analysis, phase coherence, partial direct coherence, entropy transfer, linear complexity oh, and matlab + SPSS). fmri is good but not as good as people think. 1 image/sec of something that isn't even brain activity - prety rubbish. But good when you need to localise the structures that you have found in you osscilatory anaylsis.