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Reduced Dorsal Prefrontal Gray Matter After Chronic Ketamine Use

sekio

sekio

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I don't see this being a very good omen for ketamine - or even any arylcyclohexylamine - users or abusers...

Results: We observed significant decreases in gray matter volume in bilateral frontal cortex (left superior frontal gyrus and right middle
frontal gyrus) of ketamine users in comparison with control subjects (p.05 corrected for multiple comparisons at cluster-level). Duration
of ketamine use was negatively correlated with gray matter volume in bilateral frontal cortex, whereas the estimated total lifetime ketamine
consumption was negatively correlated with gray matter volume in left superior frontal gyrus.
Click to expand...

Fulltext PDF: http://www.mediafire.com/file/fq9sf4eheeytlow/bp.2011.ketamine.graymatter.pdf
 
Sorry I couldn't download the text but where the tests run at normal human dose levels in the given animals? I ask because when researching DXM people always point to how it causes Olney's lessons but when you actually look at the tests that were conducted, it involved intravenous administration of drug levels that were much higher than any human would ever practically use.
 
^It would definitely take chronic use to build any appreciable level of cognitive deficit. Even if it did happen though, how one 'feels' would be a poor method of judging changes or deficits, especially if damage is localized rather than widespread.
 
Toxicities that are perceptible or perceptible to those close to you are, at the end of the day, what matters. If you do have measurable reducation in dorsal-prefrontal gray matter.....what are you going to do? I am far from. I am not toxicologist, but I've seen worse from more common agents. It would seem obvious that chronic ketamine abuse is, at least, not particularly good for ones health. My main encounters clinically have involved PCP variants inducing acute psychosis, most of whom appeared to 'recover'. Some did not. Whether these cases were the result of a precipitation of an underlying, or a toxicological caustion..............to be honest, no extensive imaging was done, and both patients are, in the end, treated similarly.

Daily abuse of ketamine, dose and time dependent, may result in perceptible and function damage. It is prudent to arm oneself with such information......but apply perspective..........
 
Its interesting that in the paper all of the ketamine users smoke tobacco but none of the control group do and according to wiki older smokers lose gray matter faster than non smokers.
 
chaos_destroy said:
Its interesting that in the paper all of the ketamine users smoke tobacco but none of the control group do and according to wiki older smokers lose gray matter faster than non smokers.
Click to expand...

sheesh worthless. but wrothwile info then.
Time to bust out the traditional psychedelics for them.
%)
 
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