Rectal administration of novel Benzodiazepines

[Tilex]

Hello BLers, I come to you with a few specific questions today.

I assume plugging benzos works, on the basis that anything that can be administered sublingually should also be able plugged (mucous membranes and all that), although I am aware that most benzos are not water soluble.

-Does anyone have experience with plugging novel benzos? If so, how did you prepare the solution (I assume PEG would be required for plugging since most benzos are not water soluble)
-Does plugging benzos increase the experience? Quicker onset, faster comedown, anything anecdotal?


I have searched and have found mixed opinions on whether or not it is worth it to do this from various resources, my favorite ROA is intrarectal and therefore I pose these questions.

Mostly I'm looking for fresh opinions, perspectives, and even facts if available. The specific benzo I plan on plugging is flubromazolam, in PEG solution (ouch)

 

[《Plasticity》]

Well, I can say that etizolam (which also isn't water soluble) absolutely works nasally when disolved in Propylene Glycol, so I can't imagine it not working rectally either. Mucous membranes are mucous membranes afaik. I haven't tried flubromazolam in particular but I don't see why it would be any different than etizolam in this scenario. The only reason why I would ever take etizolam nasally was because it kicks in almost instantly which is great for panic attacks, so I don't really see the appeal in plugging benzos.

The bioavailability of oral benzos are already very high and sublingual administration has a similar timeline to rectal without the risk of losing any of your dose by not having clear bowels. I'm a proponent of rectal dosing but this just seems very unnecessary and a bit silly tbh. There's only one way to find out if it works for sure, so if you're dead set on plugging it tread carefully and dose lower than normal. Because of my success with PG I would reccommend using that or PEG as the carrier, just don't use a ton of the stuff.

Most people on this site will tell you any other ROA besides oral is a waste and because it isn't water soluble it won't absorb though... even though benzos are readily absorbed by oral mucousa and I, along with others I've tested this on, can confirm that etizolam/PG works when nasal dripped. I remember quoting a few studies a while back showing that insufflation was a viable ROA for a few benzos. I'm not sure why these drugs are still being absorbed despite not being water soluble. aMT freebase, another non-water soluble drug, also works via insufflation and rectal without conversion to the soluble acetate or HCl required. People who have never tried it may claim placebo, but there's no psyching yourself into a 16+ hour aMT trip .