Misc Recreational Nutmeg metabolites

[The Holy Quadruplty]

I'm going to be working on this first post for a while so it's under construction... Lol

Recreational metabolites of Nutmeg in some humans...

 MMDA

Trimethoxyamphetamine










Possible recreational metabolites of Nutmeg in humans...

3-piperidino-1-(3,4-methylenedioxyphenyl)-1-propanone

MDA

2, 3, 4 Trimethoxycinnamic Acid

5-allyl-1-methoxy-2,3-dihydroxybenzene

Oxoelemicinphenethylamine

Amphetamine

 

[PenguinWithNapalm]

MDA?

 

[The Holy Quadruplty]

MDA?

Yes it has been detected in humans after consuming Nutmeg, but not everytime.

 

[Deleted member 578389]

once on abit much mda, i was walking at dusk and would see animals like gorillas and snakes morphing out of objects in the distance, very trippy.

i have od'd on nutmeg once (25g ground fresh) and had oev of sharp geometric moving patterns, it was not worth all of the toxic side effects lasting 3 days.

 

[red22]

It has been hypothesized that elemicine (found in nutmeg) metabolizes to TMA:

Quote:

Myristicin, elemicine, and safrole appear to be responsible for the psychoactive effects. Apparently an amination takes place during metabolism that transforms these substances into centrally active amphetamine derivatives (Isaac 1993, 883; Shulgin and Naranjo 1967; Weil 1965, 1967). Amination of myristicin yields MMDA (= 3-methoxy-4,5-methylendioxyamphetamine), a known entactogenic compound (Shulgin and Shulgin 1991*). Elemicine is transformed into TMA (3,4,5-trimethoxyamphetamine), a substance related to mescaline.[/i]

Isaac, Otto. 1993. Myristica. In Hagers Handbuch der pharmazeutischen Praxis, 5th ed., 5:863–94. Berlin: Springer.

Shulgin, Alexander T., Thornton Sargent, and Claudia [sic] Naranjo. 1967. The chemistry and psychopharmacology of nutmeg and of several related phenylisopropylamines. In Ethnopharmacologic search for psychoactive drugs, ed. D. Efron, 202–14. Washington, D.C.:
U.S. Dept. of Health, Education, and Welfare.

Weil, Andrew. 1965. Nutmeg as a narcotic. Economic Botany 19:194–217.
———. 1967. Nutmeg as a psychotropic drug. In Ethnopharmacologic search for psychoactive drugs, ed. D. Efron, 188–201. Washington, D.C.: U.S. Dept. of Health, Education, and Welfare.

The Encyclopedia of Psychoactive Plants. Christian Ratsch, 2005 (The Most Important Genera and Species from A to Z / Myristica fragrans / Constituents)

https://s3-us-west-1.amazonaws.com/ackl.me/books/TheEncyclopediaOfPsychoactivePlants.pdf


Might be relevant:

Bioanalytical investigation of asarone in connection with Acorus calamus oil intoxications. Björnstad K, Helander A, Hultén P, Beck O. J Anal Toxicol. 2009 Nov-Dec;33(9):604-9. doi: 10.1093/jat/33.9.604

 

[The Holy Quadruplty]

It has been hypothesized that elemicine (found in nutmeg) metabolizes to TMA:

Quote:

Myristicin, elemicine, and safrole appear to be responsible for the psychoactive effects. Apparently an amination takes place during metabolism that transforms these substances into centrally active amphetamine derivatives (Isaac 1993, 883; Shulgin and Naranjo 1967; Weil 1965, 1967). Amination of myristicin yields MMDA (= 3-methoxy-4,5-methylendioxyamphetamine), a known entactogenic compound (Shulgin and Shulgin 1991*). Elemicine is transformed into TMA (3,4,5-trimethoxyamphetamine), a substance related to mescaline.[/i]

Isaac, Otto. 1993. Myristica. In Hagers Handbuch der pharmazeutischen Praxis, 5th ed., 5:863–94. Berlin: Springer.

Shulgin, Alexander T., Thornton Sargent, and Claudia [sic] Naranjo. 1967. The chemistry and psychopharmacology of nutmeg and of several related phenylisopropylamines. In Ethnopharmacologic search for psychoactive drugs, ed. D. Efron, 202–14. Washington, D.C.:
U.S. Dept. of Health, Education, and Welfare.

Weil, Andrew. 1965. Nutmeg as a narcotic. Economic Botany 19:194–217.
———. 1967. Nutmeg as a psychotropic drug. In Ethnopharmacologic search for psychoactive drugs, ed. D. Efron, 188–201. Washington, D.C.: U.S. Dept. of Health, Education, and Welfare.

The Encyclopedia of Psychoactive Plants. Christian Ratsch, 2005 (The Most Important Genera and Species from A to Z / Myristica fragrans / Constituents)

https://s3-us-west-1.amazonaws.com/ackl.me/books/TheEncyclopediaOfPsychoactivePlants.pdf


Might be relevant:

Bioanalytical investigation of asarone in connection with Acorus calamus oil intoxications. Björnstad K, Helander A, Hultén P, Beck O. J Anal Toxicol. 2009 Nov-Dec;33(9):604-9. doi: 10.1093/jat/33.9.604

Are you sure your not Ron?!