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RC's and SSRI's

me0307

Bluelighter
Joined
Nov 26, 2008
Messages
326
I really want to get my gf to appreciate psychadelics - but the only problem is, shes on an SSRI (Zoloft I believe).

Last time we did 2c-I together, she didn't take her Zoloft the day of nor the day before b/c we both know SSRI's can minimize the effects of a psy.

I took 30mg's and she took 20mg; I tripped my fucking balls off, and she didnt notice anything at all. I assume it was because there was still some SSRI in her system.

I'm gonna buy some 2c-e pretty soon, any suggestions to help her actually feel the effects of the RC? Should she stop using her SSRI for a few days?
 
It takes at least 2 weeks to clear an SSRI out of the system (and personally, i'd even wait 3 or 4 weeks to ensure from any loss of experience). I did have a friend that could eat mushrooms (although he was only on a very light dose) while he took an ssri, and although he reported no visuals, he had an acceptable mindtrip; although i'd generally state SSRI's and psychedelics are mutually exclusive since they depend on the serotinergic system so much (5HTA2 being the primary receptor and all)
 
This tends to vary a lot from person to person. I was on lexapro and celexa for several years and tripped plenty of times. But i also know plenty of people that have had similar results to your girlfriend. I eventually quit taking ssri's cause i found them to be rather ineffective. The best way to counter this is to abstain for a couple days and gradually up the dose each time til effects are felt, in my opinion.
 
^Likewise. I did many different tryptamines and PEA's while on zoloft to no lessening of psychedelia. Maybe needed higher doses for PEA's though....
 
I am against SSRI's unless absolutely needed even then my belief is diet and excercise can fix most serotonin depletion problems, some food for thought!!!
 
I am against SSRI's unless absolutely needed even then my belief is diet and excercise can fix most serotonin depletion problems, some food for thought!!!

Not really food so much as opinion ;) Agrered on the food part though- but eating healthy is important in any context.

I haven't seen many sources saying exercise increases serotonin.
 
I am against SSRI's unless absolutely needed even then my belief is diet and excercise can fix most serotonin depletion problems, some food for thought!!!

while i do agree with this...

she actualy takes it for anxiety. unfortunately, i do not think she needs it - but she cant get off b/c her body is so used to having it. i think her parents are fucking stupid but thats a different topic.

thanks for all the responses!
 
while i do agree with this...

she actualy takes it for anxiety. unfortunately, i do not think she needs it - but she cant get off b/c her body is so used to having it. i think her parents are fucking stupid but thats a different topic.

thanks for all the responses!

Thats even worse and I totally disagree with the idea of using an SSRI for anxiety when there are other better options that don't fuck with your serotonin system. Thats like using an anti psychotic for sleep my god why would you screw with neurotransmitter systems that have little to do with the problem but instead achieve there effect by side effects alone which is just plain stupid!!!

I would advise her to wean off the SSRI Paxil i'm betting and get on a diet and excersise program and if that fails then continue with a Benzodiazapine like Alprolazam .25mg three times a day that should help while not fucking with the sensitive Serotonin system.

My god it makes you wonder is it the doctor prescribing these meds or the pharm industry, the latter I bet!!!
 
^Advice to use benzo's is the worse advice I could give. Serotonin system is not so sensitive; or, if so, why do we conciously agonise it with psychedelics? Also- benzo's do reduce the levels of serotonin, so the net result of using them longterm (besides hellish withdrawal) can and often is, depression.
 
Have you ever been through Paxil WD's??? I think not and the serotonin system not being sensitive hahaha look what paxil does when you stop it and tell me that its a better bet then benzos and .25mg three times a day is relitively easy to wean off if one needs to but its the safest bet for anxiety that is life crippling!!!
 
Anxiety comes from subconscious fears, and the best way to deal with subconscious fears is to make them conscious and face them. Ie. If you have social anxiety, purposely force yourself into social situations. A medication will not fix anyone's problems.
 
Anxiety comes from subconscious fears, and the best way to deal with subconscious fears is to make them conscious and face them. Ie. If you have social anxiety, purposely force yourself into social situations. A medication will not fix anyone's problems.

I totally agree and this often helps to the point of almost curing the problem but there are instances that medication is required but i'd say only 5% if that of the people on medication really need it!!!
 
^ and ^^^
exactly. these kind of things, esp. SSRIs (prozac! come get your prozac here!) get prescribed so many times for a plethora of symptoms which they will never cure; viable routes pertaining an actual (!) cure (eg. psychotherapy) are barely looked at anymore. instead, just pop a pill a day and your well on your way $$.
 
on topic...

Yeah you need a lot of time to clean out SSRI use. And in her case if she's been takin it daily then this is especially true.

She is in what we call a pickle.
 
Should she stop using her SSRI for a few days?


Under no circumstances as the rebound (withdrawl) from suddenly stopping an SSRI can be horrendus, with fits of violent temper that'd give steroids a good run for their money. SSRI's NEED to be tapered down gradually to prevent this


I am against SSRI's unless absolutely needed even then my belief is diet and excercise can fix most serotonin depletion problems, some food for thought!!!

Without a detailed medical history to hand, how could you know whether she needs to be taking SSRIs or not. Telling someone to stop without knowing the full story ranges from a bad descision to plain wreckless


I would advise her to wean off the SSRI Paxil i'm betting and get on a diet and excersise program and if that fails then continue with a Benzodiazapine like Alprolazam .25mg three times a day that should help while not fucking with the sensitive Serotonin system.


So instead you propose the person starts with a drug which produces a physical dependance which can lead to fatalities if suddenly withdrawn. Also, you're just replacing fucking with serotonogic system to fucking with the GABA system, which could be described as equally as sensitive, if not moreso


Have you ever been through Paxil WD's??? I think not and the serotonin system not being sensitive hahaha look what paxil does when you stop it and tell me that its a better bet then benzos and .25mg three times a day is relitively easy to wean off if one needs to but its the safest bet for anxiety that is life crippling!!!

I have & I'd rather endure that again than go through months of withdrawl symptoms that benzo addicts report. Benzos are far from the safest method of dealing with anxiety


Anxiety comes from subconscious fears, and the best way to deal with subconscious fears is to make them conscious and face them. Ie. If you have social anxiety, purposely force yourself into social situations. A medication will not fix anyone's problems.


The best and safest way of dealing with chronic, debilitating anxiety is to get involved with CBT (cognative behaviour therapy) which teaches you to avoid the thought processes that lead to anxiety. CBT brings the causes of anxiety to the concious mind and then shows coping mechanisms that don't depend upon a regieme of drugs with potentially nasty side effects from continuous use.

Thing is, these days we're used to the idea of instant gratification, which is most abily demonstrated by drug use (you carry out an action & get immediately rewarded). CBT does not give the instant gratification & also involves some hard work on the behalf of the patient, but in the end is a cure for the anxiety state. All anti-anxiety drugs do not cure the anxiety, but are merely a sticking plaster type of solution ie a temporasry one, not a perm one and as such should not be used long term.

Personally I think this instant gratification mindset is at the route of a lot of society's problewms as people are less & less inclined to put effort into something wher the reward is a long time off. As for SSRI's, I wouldn't touch them againm after having them prescribed in the past for my SAD, but that doesn't mean that I'm against them per se as I've seen some people who have benefitted enormously from using them.




Oh and one more thing - RC's are not an homogeneous group of drugs with the same mechanism of action or chemical structure, it's a broad ranging title that covers a range of drugs with only one thing in common - that they have no long term/detailed history of use in man and are generally unexplored territory. As such, there's no answer thast can be given for interactions between SSRIs & RCs
 
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Are we not forgetting the neurochemical component to anxiety here? I can see anxiety arising from pretty much nothing at all if you fuck with stuff like your dopamine system and that kind of thing.
The same goes for depression IMO. Sure there are many many cases in which there are grounds to become depressed but let's not forget that you can just feel lousy by depleting your neurotransmitters though I have to say that has a particular feeling. I think I have felt the difference between having a reason to feel bad or just having a chemical imbalance, even without asking yourself if there is actually something the matter there is a distinct difference. Maybe you can sense if it is chronic or acute / temporary?

The crux of the matter often is though: where does the psychology stop and where does the chemistry begin? Sometimes you can get into a vicious circle caused by thoughts and exacerbated by chemistry. Or the other way round!

It's not entirely the subject of discussion but fastandbulbous pretty much made some solid points.

(0.02)
 
I would advise her to wean off the SSRI Paxil i'm betting

Read the first post matey before going all !!!!!!!!!!! everywhere. Its zoloft; quite a different chemical.

I've been on Paxil and yes, withdrawal sucked- but compared to the withdrawal I have and am experiencing from benzo use, its a breeze.

If you don't like a class of drugs, thats fine- but don't let that cloud your advice to people who may (surprsingly, I know) be utterly different to you.
 
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