Quick Question About Tramadol, MDMA, and Serotonin Syndrome

[DoorsofPerception]

So, I'm trying to be as safe as possible with some drug interactions here and have a few questions.

First, I've been taking small doses of xanax each day (less than 1mg) for anxiety issues and decided to take a small dose (50mg) of tramadol last night to see if the benzo would get rid of the jitteriness and unpleasant physical effects I sometimes experience from tramadol on its own and also work to reduce any seizure potential. I'm pretty sure I took the tramadol around 9:00pm last night.

So, my question is...my friend scored some really potent MDMA and wants to chill with me at a bar tonight. So far today I've taken about 3 doses of 0.5 mg xanax spaced out over a couple hours. I'm wondering if it is worth it to partake in some of the MDMA tonight because I might not get a chance to see any for a long time.

Obviously, my health comes above any type of drug use and I'm a little uneasy about taking the MDMA only 24 hours apart from the tram dose, even though it was a really small dose and I haven't taken it in quite a long time previously, meaning there is no buildup of the drug in my system.

What's the best recommendation? Is there a high percent chance that I would experience serotonin syndrome? Will the xanax help in that department at all?

Thanks to any and all that can help me out!

Also, I posted this in the MDMA forum, but realized it would probably be better suited here so feel free to delete that thread. Sorry!

 

[Pilll_head]

The half life of tramadol is short enough that 24 h should be enough time before the MDMA dose. I don't think there would be any interaction with Xanax which is a GABA-A agonist and does not bind to serotonin receptors.