necropolis
Bluelighter
Psychedelic phenmetrazine analogues, anyone? I was thinking about this the other day.
A couple of examples might be 3-methyl-[2-(2,5-dimethoxy-4-methylphenyl)]morpholine and 3-methyl-[2-(2,5-dimethoxy-4-chlorophenyl)]morpholine. I wonder if any such compounds might show appreciable affinity for the 5-HT2A receptor, in general maintaining the conventional substitution pattern of a halogen, methyl, or sulfur substituent at the 4-position of the phenyl ring with a methoxy at the 2- and 5- positions. At the other end of the compound, other cyclic amines (e.g. piperidine, pyrrolidine and others) could be explored. No way of knowing short of synthesis and testing (or docking studies at the very least), whether any such hypothetical substances would maintain the right pharmacology to be active as psychedelics. It'd be interesting to find out though. To me anyway. Any thoughts/comments/criticisms are much appreciated.
A couple of examples might be 3-methyl-[2-(2,5-dimethoxy-4-methylphenyl)]morpholine and 3-methyl-[2-(2,5-dimethoxy-4-chlorophenyl)]morpholine. I wonder if any such compounds might show appreciable affinity for the 5-HT2A receptor, in general maintaining the conventional substitution pattern of a halogen, methyl, or sulfur substituent at the 4-position of the phenyl ring with a methoxy at the 2- and 5- positions. At the other end of the compound, other cyclic amines (e.g. piperidine, pyrrolidine and others) could be explored. No way of knowing short of synthesis and testing (or docking studies at the very least), whether any such hypothetical substances would maintain the right pharmacology to be active as psychedelics. It'd be interesting to find out though. To me anyway. Any thoughts/comments/criticisms are much appreciated.